A5101930127- Retinoids in leukemia and cellular processes
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Inflammatory mediators and NSAID effects
- Nuclear Receptors and Signaling
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Surfactants and Colloidal Systems
- RNA Research and Splicing
- Eicosanoids and Hypertension Pharmacology
- Peroxisome Proliferator-Activated Receptors
- Nitric Oxide and Endothelin Effects
- Neuroblastoma Research and Treatments
- Retinal Development and Disorders
- Heavy Metal Exposure and Toxicity
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Macrophage Migration Inhibitory Factor
- Monoclonal and Polyclonal Antibodies Research
- Circular RNAs in diseases
- Hemoglobin structure and function
- Spectroscopy and Quantum Chemical Studies
- Neuroscience of respiration and sleep
- Glycosylation and Glycoproteins Research
- Viral Infectious Diseases and Gene Expression in Insects
Shantou University Medical College
2014-2025
Shantou University
2014-2025
Tsinghua University
2024
Cancer Hospital of Shantou University Medical College
2023
Beijing Institute of Petrochemical Technology
2023
Key Laboratory of Guangdong Province
2014
Harbin Institute of Technology
2009
Xi’an University
2008
China National Petroleum Corporation (China)
2008
Kagawa University
1995-1999
Abstract Insulin resistance (IR) and abdominal obesity are key in osteoarthritis (OA) development. The triglyceride glucose (TyG) index, along with indicators such as the visceral adiposity index (VAI), lipid accumulation product (LAP), increasingly used to measure IR. This study aims explore associations between surrogate IR indexes OA, assessing their diagnostic efficacy within American populations. included 14,715 adults from National Health Nutrition Examination Survey 2003–2016....
The human genome, like other mammalian genomes, encodes numerous natural antisense transcripts (NATs) that have been classified into head-to-head, tail-to-tail, or fully overlapped categories in reference to their sense transcripts. Evidence for NAT-mediated epigenetic silencing of transcription remains scanty. DHRS4 gene a metabolic enzyme and forms cluster with its two immediately downstream homologous genes, DHRS4L2 DHRS4L1, generated by duplication. We identified head-to-head NAT DHRS4,...
Abstract The human DHRS4 gene cluster consists of and two immediately downstream homologous genes, DHRS4L2 DHRS4L1 , generated by evolutionarily gene-duplication events. We previously demonstrated that a head-to-head natural antisense transcript (NAT) denoted DHRS4-AS1 regulates all three genes the cluster. However, it is puzzling did not evolve their own specific NATs to regulate themselves, as seems both have retained sequences highly . In search region for nearby enhancers, we identified...
This study was to determine whether the endothelium of mouse major arteries produces prostacyclin (PGI(2)) and, if so, how PGI(2) affects vasomotor reactivity and cyclo-oxygenase-1 (COX-1) contributes synthesis. Abdominal aortas, carotid femoral were isolated from wild-type mice and/or those with COX-1 or -2 deficiency (COX-1(-/-); COX-2(-/-)) for biochemical functional analyses. The metabolite 6-keto-PGF(1α) analysed high-performance liquid chromatography-mass spectroscopy, while...
High expression of secreted matricellular protein cysteine-rich 61 (CYR61) correlates with poor prognosis in colorectal cancer (CRC). Aberrant enhancer activation has been shown to correlate key genes involved progression. However, such mechanisms CYR61 transcription regulation remain unexplored.Expression was determined by immunohistochemistry (IHC), quantitative real-time PCR (qRT-PCR) and western blotting (WB) CRC patients paraffin specimens colon cell lines. ChIP-seq data...
Prostate cancer is a common carcinoma in males, the development of which involves androgen receptor (AR) as key regulator. AR transactivation induces high expression androgen-regulated genes, including transmembrane protease serine 2 (TMPRSS2) and long noncoding RNA prostate cancer-associated transcript 38 (PRCAT38). PRCAT38 TMPRSS2 are both located on chromosome 21, separated by series enhancers. prostate-specific that highly expressed tissue compared to normal tissue. Here, we show...
Background Esophageal squamous cell carcinoma (ESCC) is a highly aggressive cancer whose underlying molecular mechanisms are poorly understood. The natural antisense transcript (NAT) WRAP53 regulates p53 expression and protein component of telomerase. NATs play key roles in carcinogenesis, although known to increase survival, its role ESCC clinicopathology unknown. aim this study was investigate correlate it with clinicopathological characteristics. Methods mRNA measured by quantitative PCR...
HMGB3 belongs to the high-mobility group box subfamily and has been found be overexpressed in gastric cancer. However, expression role of human hepatocellular carcinoma remain unknown. Here, we report that HMGB3, which is suppressed by miR-200b, contributes cell proliferation migration carcinoma. After analyzing The Cancer Genome Atlas data 371 patients with carcinoma, identified upregulated tissue. Knockdown line migration. TargetScan analysis showed miR-200b a possible regulator for HMGB3....
NR4A1 acts as an oncogene and plays important role in colorectal cancer development progression, but little is known about the regulatory mechanism of expression.MicroRNA (miRNA) involved progression various tumors, affecting proliferation, apoptosis or migration.We aimed to elucidate whether miRNA regulates expression determine its underlying significance cancer.By using TargetScan database, we identified a miR-506 binding site 3'-UTR.Examination tissues cells revealed that mRNA protein...
This study aimed to determine whether PGI(2) would be evoked by the endogenous endothelial B(2) receptor agonist bradykinin (BK) in porcine interlobular renal artery and, if so, how it influence vasomotor reaction, and specific cyclooxygenase (COX) isoform(s) involved its synthesis. The production of metabolite 6-keto-PGF(1α) was analyzed with HPLC-mass spectroscopy, while reaction or BK determined isometric force measurement. Results showed that an increase 6-keto-PGF(1α), which abolished...
The objective of this study was to determine the role cyclooxygenase (COX)-1 or -2 in endothelium-dependent contraction under atherosclerotic conditions. Atherosclerosis induced apoE knockout (apoE(-/-)) mice and those with COX-1(-/-) (apoE(-/-)-COX-1(-/-)) by feeding high fat cholesterol food. Aortas (abdominal whole section) were isolated for functional and/or biochemical analyses. As non-atherosclerotic conditions, muscarinic receptor agonist acetylcholine (ACh) evoked an...
Long non-coding RNAs (lncRNAs) play important roles in tumorigenesis and cancer progression. The orphan nuclear receptor subfamily 4 group A member 1 (NR4A1) acts as an oncogene, is involved colorectal (CRC) development. However, the mechanism through which lncRNA regulates NR4A1 expression remains unknown. We aimed to identify lncRNAs that regulate assess their underlying mechanisms CRC. first identified antisense of was up-regulated CRC tissues cells with rapid amplification cDNA ends...
This paper presents an application of adaptive fuzzy sliding mode control (AFSMC) for a benchmark problem on seismically excited highway bridge. approach combines great advantages (SMC), and without compromising the stability or robustness. Switching-type law conventional SMC uncertainty part equivalent is approximated by controller to attenuate chattering phenomenon harmful effects caused uncertainties. In order reduce complexity rule bases, based Lyapunov function Barbalat lemma designed....
microRNA regulation network is important for the cancer genetic heterogeneity.Relative to increasing numbers of microRNA's targets identified, upstream regulatory mechanisms that control functional microRNAs are less well-documented.Here, we investigated function miR-31, a pleiotropically-acting microRNA, in esophageal squamous cell (ESCC).We demonstrated miR-31 only exerted tumor-suppressive effects TE-7 ESCC cells, but not TE-1 although both these lines harbor inactive p53.Interestingly,...
This study aimed to determine whether the cyclo-oxygenase (COX) substrate arachidonic acid (AA) evokes endothelium-dependent contraction and, if so, specific COX isoform(s) involved and prostacyclin (prostaglandin I2; PGI2), a mediator of endothelium-derived vasoconstrictor activity, can be generated in medial smooth muscle from intermediate product prostaglandin H2 (PGH2) that might diffuse endothelium. Aortae and/or carotid arteries were isolated C57BL/6 mice or those lacking one two...