Background: Low-dose naltrexone (LDN) may promote psychological well-being as well generalized health especially in autoimmune disorders. The objective of this study is to assess the effect LDN on Quality Life (QoL) patients with relapsing—remitting and secondary progressive multiple sclerosis (MS) using scales composite scores MSQoL-54 questionnaire. Methods: A 17-week randomized, double-blind, placebo-controlled, parallel-group, crossover-design clinical trial was conducted two...

Background: Despite a favorable clinical experience, little evidence exists for the efficacy of greater occipital nerve block (GONB) in migraine treatment. Considering such premise, we wished to evaluate therapeutic GONB patients affected by headaches. Methods: A randomized double-blinded controlled trial was conducted on 48 suffering from syringe containing 1.0 mL lidocaine 2%, 0.5 either saline (control group, N = 24) or triamcinolone (intervention prepared each patient. Patients were...

Migraine is not curable, but preventive treatments are usually used to decrease the intensity and frequency of headache attacks. Different therapeutic options widely studied for chronic migraine (CM), all them have different inefficacies.The aim this study was compare efficacy levetiracetam versus sodium valproate in treatment CM.A randomized controlled clinical trial conducted on 62 patients with (30 intervention group-treated 32 control group- treated valproate). The regimen consisted...

Methamphetamine (METH) is a psychostimulant drug widely used because of its arousing, euphoric and hallucinogenic properties. Studies have reported that chronic METH abuse causes neurotoxic effects in the central nervous system (CNS), including alterations dopaminergic terminals, gray matter atrophy, microgliosis different parts CNS. administration leads to enhancement extracellular dopamine serotonin. Moreover, increases glutamate release induces excitotoxicity due dysregulation. use...

To determine the effects of Perturbation-based Balance Training (PBT) on postural responses and falls in people with multiple sclerosis (PwMS) compare results conventional balance training (CBT).Thirty-four PwMS were randomized to receive 4 weeks PBT or CBT. Latency external perturbations, Timed-Up-and-Go (TUG), 10-meter-walk (10MW), Berg Scale (BBS), Activities-specific Confidence (ABC) measured at baseline post-training. Also, proportion fallers fall rate assessed a 3-month follow-up.The...

Background: Juvenile myoclonic epilepsy is the most common type of generalized idiopathic epilepsy. Sodium valproate first line medications, but has many complications and 15% patients are resistant to this medicine. This a lifelong disease in case stopping medication, relapsing seizures seen more than 80% cases. Objectives: Analysis effectiveness these two drugs on controlling by comparing them mono therapy treatment JME represent levetiracetam as replacement sodium for medication JME....

Carpal Tunnel Syndrome (CTS) is a common problem that caused by pressure on nerve in the wrist and associated with various factors.We compared Cross-Sectional Area (CSA) of inlet outlet CTS patients healthy controls define best cut off point CSA assess utility US diagnosis as well.This cross-sectional, age-group-matched case-control study was performed 39 aged 42-65 years electro-physiologically confirmed idiopathic 35 from Golestan Hospital, Ahvaz, Iran Jan 2013 to Feb 2014.Neurological...

Background: Recent research shows that most of the patients with multiple sclerosis (MS) have cognitive-like disorders. Due to beneficial effects atomoxetine on improving cognition in limited animal and human surveys, aim present study was investigate effect cognitive disorders MS. Methods: This a parallel, randomized clinical trial, designed drug improvement impairment (CI) MS, from April 2021 March 2022. According inclusion exclusion criteria, total 52 participants were involved then...

Abstract Background Accumulating evidence on the neurological sequelae of COVID-19 is a serious concern, with patients possibly being at risk permanent debilitation if not managed appropriately. We aimed to determine prevalence and pattern manifestations diagnostic therapeutic findings among hospitalized consulted neurology service for disorders. conducted retrospective, observational study Golestan Hospital Ahvaz, Iran, between March 20, 2020, 19, 2021. Patients' demographic, clinical,...

We reported a pediatric case of SuS with complete diagnosis triad. Although the optimal treatment SS is unclear, prompt and can result in almost recovery.

Background: It has been proposed that colchicine may have the potential to prevent cardiovascular and cerebrovascular dysfunctions. Objective: This study evaluated impact of on preventing recurrent stroke in patients with both ischemic (IS) atrial fibrillation (AF). Methods: A randomized, double-blinded, placebo-controlled trial was conducted at Golestan Hospital (Ahvaz, Iran) over one year, involving IS AF. Demographic clinical data were collected from participants, who then assigned either...

Introduction: Freezing of gait (FOG) is a debilitating symptom experienced by many individuals with Parkinson’s disease, characterized an abrupt and transient inability to initiate or continue locomotion. Despite extensive research, effective pharmacological interventions targeting FOG remain elusive. Atomoxetine, selective norepinephrine reuptake inhibitor, has shown promise in alleviating small-scale studies. However, the efficacy atomoxetine larger cohorts remains underexplored....

Background and Purpose: The Multiple sclerosis walking scale-12 (MSWS-12) the Modified Fatigue Impact Scale (MFIS) are two popular outcome measures applied widely for assessing self-perceived ability fatigue in people with multiple (PwMS). present study aimed to examine responsiveness clinically meaningful changes Persian versions of MSWS-12 MFIS following balance gait rehabilitation PwMS.Methods: Fifty-eight PwMS completed before after 4 weeks rehabilitation. Also, a 7-point global rating...

Background: Stroke is the third main cause of death and chronic disabilities in adults, which requires finding neuroprotective drugs to reduce its mortality morbidity. Objectives: To determine efficacy magnesium sulfate as an adjunctive agent patients with stroke. Materials & Methods: This randomized double-blind clinical trial recruited 120 acute ischemic stroke middle cerebral artery territory presenting Ahvaz Golestan Hospital from 2015 2016. The were randomly assigned into two...

Background: The study aimed to judge the safety and possible side effects of rituximab (RTX) drug in patients with multiple sclerosis (MS). Methods: This retrospective observational was performed on 91 MS who had been treated RTX between 2016 2019. Each patient visited examined a minimum once. therefore drug-related reactions injection were asked via phone calls, which recorded separately as mild, moderate, severe modes necessity for hospitalization. Results: A total enrolled within study:...

Background and Aim: Alteplase is a thrombolytic drug that produced by recombinant DNA technology. Tissue plasminogen activator enzyme which converts to the active form of plasmin also same technology; it causes fibrinolysis clot dissolution. This study aimed compare efficacy complications injection in patients with acute ischemic stroke (AIS( during first 3 hours and  3-4.5 after onset symptoms. Methods: In this study, AIS who were referred Golestan Hospital Ahvaz city 2018-2019 selected....

Background: Drooling is an annoying problem in some neurologic and systemic diseases. Injecting botulinum toxin the salivary glands one of most effective safest treatments. Objectives: This study was conducted to evaluate effect on amount sialorrhea patients with Materials methods: included ten 60 units type A (Dysport) were injected any submandibular gland 120 parotid bilaterally under ultrasonographic guide. To check drooling, daily consumption tissue counted it cheeked once before...

Background: Injury to the external branch of superior laryngeal nerve (EBSLN) results in deterioration postoperative voice performance. The aim this study was asses impact exploring and identifying EBSLN during thyroidectomy reducing injury consequently preserved Methods: Ninety patients, 2 groups, underwent a total 122 upper poles were dissected. After 4 weeks, patients with complaints evaluated by electromyography cricothyroid muscle. Results: There unilateral injuries (10%) explored group...