A5050934442- Heart Failure Treatment and Management
- Cardiac Health and Mental Health
- Pulmonary Hypertension Research and Treatments
- Cardiovascular and exercise physiology
- Cardiovascular Function and Risk Factors
- Clinical Nutrition and Gastroenterology
- Cancer therapeutics and mechanisms
- Heart Rate Variability and Autonomic Control
- Liver Disease and Transplantation
- Muscle metabolism and nutrition
- Anesthesia and Neurotoxicity Research
- Mesenchymal stem cell research
- Bioactive Compounds and Antitumor Agents
- Neuroscience and Neuropharmacology Research
- Pancreatic function and diabetes
- Adenosine and Purinergic Signaling
- Synthesis of Indole Derivatives
- Muscle Physiology and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Medication Adherence and Compliance
University of Bremen
2020-2024
Stiftung Rehabilitation Heidelberg (Germany)
2006-2016
Hohenstein Institute
2012
Justus-Liebig-Universität Gießen
2006-2012
University of Freiburg
2012
Heidelberg University
2006
University Hospital Heidelberg
2006
DRK Kliniken Berlin
2006
Medical University of Graz
2006
Leibniz University Hannover
2006
Background— Pulmonary hypertension (PH) is associated with restricted physical capacity, limited quality of life, and a poor prognosis because right heart failure. The present study the first prospective randomized to evaluate effects exercise respiratory training in patients severe symptomatic PH. Methods Results— Thirty PH (21 women; mean age, 50±13 years; pulmonary artery pressure, 50±15 mm Hg; World Health Organization [WHO] class, 2.9±0.5; arterial hypertension, n=23; chronic...
The objective of this prospective study was to assess safety and efficacy exercise training in a large cohort patients with different forms World Health Organization (WHO) functional classes chronic pulmonary hypertension (PH). 183 PH (pulmonary arterial (PAH), thromboembolic due respiratory or left heart diseases received hospital for 3 weeks continued at home. Adverse events have been monitored during the in-hospital programme. Efficacy parameters were evaluated baseline, after 15 weeks....
The glucose analogue 2-deoxyglucose (2DG) has frequently been used as a tool to study cellular uptake and inhibit glycolysis. Exposure of primary cultured astrocytes 2DG caused time- concentration-dependent accumulation 2-deoxyglucose-6-phosphate (2DG6P) that was accompanied by rapid initial decline in ATP content. Inhibitors mitochondrial respiration well inhibitors pyruvate activated fatty acids accelerated the loss, demonstrating regeneration contributes partial maintenance content...
Chronic heart failure requires a complex treatment regimen on life-long basis. Therefore, self-care/self-management is an essential part of successful and comprehensive patient education warranted. However, specific information program features educational strategies enhancing success lacking. This trial aims to evaluate patient-oriented theory-based self-management group as compared usual care during inpatient cardiac rehabilitation in Germany. The study multicenter cluster randomized...
Abstract Adenosine triphosphate (ATP) is the main energy currency of all cells, while creatine phosphate (CrP) considered as a buffer high energy-bond that facilitates rapid regeneration ATP from adenosine diphosphate (ADP). Astrocyte-rich primary cultures contain ATP, ADP and monophosphate (AMP) in average specific contents 36.0 ± 6.4 nmol/mg, 2.9 2.1 nmol/mg 1.7 respectively, which establish an adenylate charge 0.92 0.04. The cellular CrP level was found to be 25.9 10.8 CrP/ATP ratio 0.74...
β-lapachone (β-lap) is reduced in tumor cells by the enzyme NAD(P)H: quinone acceptor oxidoreductase 1 (NQO1) to a labile hydroquinone which spontaneously reoxidises β-lap, thereby generating reactive oxygen species (ROS) and oxidative stress. To test for consequences of an acute exposure brain cultured primary rat astrocytes were incubated with β-lap up 4 h. The presence concentrations 10 µM had no detectable adverse consequences, while higher compromised cell viability metabolism...
Abstract A high cellular concentration of adenosine triphosphate (ATP) is essential to fuel many important functions brain astrocytes. Although ATP depletion has frequently been reported for astrocytes, little known on the metabolic pathways that contribute restoration by ATP-depleted Incubation cultured primary rat astrocytes in glucose-free buffer 60 min with mitochondrial uncoupler BAM15 lowered content around 70%, total amount phosphates 50% and adenylate energy charge (AEC) from 0.9...