A5010293146- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Circular RNAs in diseases
- Advanced X-ray and CT Imaging
- Metastasis and carcinoma case studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Histone Deacetylase Inhibitors Research
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Infrared Thermography in Medicine
- Liver Disease and Transplantation
Jiangsu Cancer Hospital
2020-2025
Nanjing Medical University
2021-2025
Second Affiliated Hospital of Zhejiang University
2015
Sorafenib is the first‑line treatment for advanced hepatocellular carcinoma (HCC). Since many HCC patients experience drug resistance, there an urgent need to discover more effective therapeutic strategies overcome resistance. Long non‑coding RNAs (lncRNAs) play important role in tumor However, research on of lncRNA H19 sorafenib resistance quite limited. In present study, CCK‑8 assay, RT‑qPCR, EdU staining, immunofluorescence and western blot analysis were used detect effect cells....
The role of adjuvant transarterial chemoembolization (TACE) for HCC following curative resection remains controversial. We aimed to determine the effectiveness postoperative TACE in patients with HCC. In this randomized phase 3 trial, histologically confirmed (American Joint Committee on Cancer TNM stage I and II) were randomly assigned (1:1) or observation groups. primary endpoint was recurrence-free survival (RFS) intention-to-treat (ITT) population. secondary endpoints included...
Most existing models for predicting liver metastasis primarily rely on single clinical indicators or traditional imaging features, which, while useful, offer limited accuracy and reliability. In recent years, spectral computed tomography (CT) has emerged as a dual-energy technology that provides detailed quantitative analyses of the blood supply characteristics metabolic activity tumors. The integration serum biomarkers such carcinoembryonic antigen (CEA) cancer 19-9 (CA19-9) with CT...
Ubiquitination displays a crucial role in various biological functions, such as protein degradation, signal transduction, and cellular homeostasis. Accumulating evidence has indicated that ubiquitination is essential cancer progression. Ubiquitin-conjugating enzyme E2S (UBE2S) member of ubiquitin-conjugating family the ubiquitin system its hepatocellular (HCC) largely unknown. We investigated UBE2S HCC found upregulation relevant with large tumor size, recurrence, advanced TNM stage, serving...
Objective To explore the clinical effects of S-1 single agent chemotherapy for patients undergoing radical resection cholangiocarcinoma. Methods The data 51 receiving cholangiocarcinoma who were admitted to Second Affiliated Hospital Zhejiang University from November 2011 December 2013 retrospectively analyzed. After cholangiocarcinoma, 25 non-special treatment and 26 divided into operation group group, respectively. was taken orally twice per day. Forty mg/ once applied with body...