A5054167198- Medicinal Plants and Neuroprotection
- Natural Compound Pharmacology Studies
- Therapeutic Uses of Natural Elements
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Tryptophan and brain disorders
- Cholinesterase and Neurodegenerative Diseases
- Ziziphus Jujuba Studies and Applications
- Medicinal plant effects and applications
- Ginger and Zingiberaceae research
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Pharmacological Effects of Natural Compounds
- Ginkgo biloba and Cashew Applications
- Scientific Research and Studies
- Phytochemicals and Medicinal Plants
- Natural Antidiabetic Agents Studies
- Saffron Plant Research Studies
- Herbal Medicine Research Studies
- Moringa oleifera research and applications
- Helicobacter pylori-related gastroenterology studies
- Medicinal Plant Research
- Pain Mechanisms and Treatments
- Biochemical effects in animals
- Natural product bioactivities and synthesis
University of Ibadan
2012-2024
Yahoo (United Kingdom)
2021
Central Drug Research Institute
2013
Major attention has been on dietary and medicinal phytochemicals that inhibit or reverse abnormal conditions caused by nociceptive inflammatory stimuli. Garcinia kola (Guttiferae) seed, known as "bitter kola", plays an important role in African ethno-medicine traditional hospitality like the treatment of inflammation, colds, bronchitis, bacterial, viral infections. A number useful have isolated from most prominent them is kolaviron (Garcinia bioflavonoid), which suggested to antinociceptive...
Vernonia amygdalina is well known as a medicinal plant in folk medicine antidiabetic, anthelmintic, antimalarial, laxative/purgative, and expectorant among others.This study was conducted to investigate the antinociceptive anti-inflammatory effects of V. amygdalina.Methanol extract leaf (MEVA) evaluated for effect possible mechanisms action presence naloxone (1 mg/kg), atropine (2 prazosin mg/kg) using acetic acid writhing test mice. The carrageenan hind paw edema air pouch models. Protein...
Methanol extract of Cola nitida (MECN) was evaluated for its anti-inflammatory and analgesic activities using rats mice. Inflammatory activity MECN assessed by carrageenan-induced paw oedema while acetic acid -induced writhing formalin lick test. Histological analyses the paws were also carried out. There evaluation mechanism(s) action naloxone, a blocker opioid receptors; atropine, muscarinic propranolol, beta adrenergic receptors. Findings from study revealed that has both properties....
Abstract Background : Ethanolic leaf extract of Cnidoscolus aconitifolius was evaluated for analgesic and anti-inflammatory activities. Methods The activity the assayed by formalin-induced paw licking test, acetic acid-induced abdominal writhing hot plate whereas its determined effects on carrageenan-induced edema. Results C. prolonged reaction time mice to pain in a dose-dependent manner. optimal effect obtained when administered 90 min before stimulation test. (100 or 200 mg/kg b.w.)...
Abstract Purpose Ocimum gratissimum L. leaves has been traditionally used for management of febrile illnesses and symptoms typified sickness behavior. In this work we investigated the modulatory effect flavonoid-rich fraction O. (EAFOg) on behavior, inflammatory oxidative stress responses in LPS-challenged mice. Method leaf was first extracted with n-hexane, chloroform methanol, EAFOg obtained by ethylacetate partitioning a sequentially resultant methanol extract. The (25–100 mg/kg) acute...
Objectives: Honey contains phenolic acids and flavonoids, which are significant in developing drugs against neuroinflammation. The study was designed to evaluate the ameliorative potential of honey lipopolysaccharides-induced neuroinflammation.Methods: Thirty male Wistar rats were divided into six groups, namely: control group (10 mL/kg vehicle), LPS only (250 µg/kg), (0.26, 0.31 0.36 g/kg) ibuprofen (100 mg/kg). µg/kg i.p) administered for 7days followed by treatment with Ibuprofen another...
Parkinson's disease (PD) is a chronic neurodegenerative that occurs progressively with time. Current PD treatments are symptomatic moderate effects on striatal dopamine release. Previously, the ethnomedicinal benefits of Zingiber officinale Roscoe have been demonstrated to possess broad range pharmacological benefits, but no single data its effect against nigrostriatal degeneration in model has reported. Proactive neuroprotective and pharmacotherapeutic approaches asymptomatic needed prevent...
Ameliorative effects of Musa sapientum peel extract (MSPE) were studied on Acetic Acid (AA)-induced colitis in rats. From a dose response study, the effective and yet, safe for treatment AA-induced rats was determined, also, further study carried out to determine fraction(s) MSPE that will be useful AA induced Colitis with 0.2 ml 6% acetic acid through lower abdominal laparotomy. Treatment graded doses methanolic dried (MS) (50, 100 200 mg/kg) 7 days showed 50 mg/kg as an optimal healing...
Journal of Pharmaceutical Research International (ISSN: 2456-9119) is dedicated to publish high quality papers in all areas pharmaceutical Science including drugs, community pharmacy, hospital clinical compounding consultant internet veterinary nuclear military pharmacy informatics, pharmaceutics, medicinal chemistry, pharmacognosy, pharmacotherapy, pharmacodynamics, pharmacokinetics, pharmacology, neuropharmacology, psychopharmacology, pharmacogenetics, pharmacogenomics,...
Aims: Cnidoscolus aconitifolius (CA) is a plant known to possess very high phenolic compound. The study evaluated hematological indices, anti-oxidative properties and gastroprotective potentials of CA leaf-supplemented diet.
 Methodology: Male Wistar rats weighing between 80-100 g were divided into 5 groups n=18. Group 1 animals fed with normal diet 2-5 diets supplemented 1%, 2.5%, 5% 10% C. powdered leaves continuously for 4, 8 12 weeks. Hematological indices examined in the whole...
:Lipopolysaccharides (LPS) is an agent that used to initiate neuroinflammation in animal experimental model. Thus, leading neurotoxicity and behavioral deficit. These effects are thought be caused by significant increase the level of pro-inflammatory mediators Central nervous system. However, not much known about anti-neuroinflammatory properties Waltheria americana leaf LPS- induced neuroinflammation. purpose this study was evaluate methanol extract (MEWA) animals. : Leaves W. were...