A5003899326- Microtubule and mitosis dynamics
- Immune cells in cancer
- Cancer-related Molecular Pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Ubiquitin and proteasome pathways
- Immunotherapy and Immune Responses
- Carcinogens and Genotoxicity Assessment
- Photosynthetic Processes and Mechanisms
- Cancer Immunotherapy and Biomarkers
- PARP inhibition in cancer therapy
- Childhood Cancer Survivors' Quality of Life
- Glioma Diagnosis and Treatment
- Plant nutrient uptake and metabolism
- Effects of Radiation Exposure
- Occupational and environmental lung diseases
The University of Queensland
2019-2025
Mater Research
2024-2025
UNSW Sydney
2022
Northern Sydney Local Health District
2019-2020
Royal North Shore Hospital
2019-2020
Aurora B kinase (AURKB) inhibitors have been trialled in a range of different tumour types but are not approved for any indication. Expression the human papilloma virus (HPV) oncogenes and loss retinoblastoma (RB) protein function has reported to increase sensitivity AURKB mechanism their contribution is poorly understood. Two commonly outcomes inhibition polyploidy senescence, although relationship unclear. Here we investigated major cellular targets HPV E6 E7, p53 RB, determine inhibitor...
Glioblastoma, the most aggressive form of glioma, has a 5-year survival rate <5%. While radiation and immunotherapies are routinely studied in murine Gl261 glioma model, little is known about its inherent immune response. This study quantifies temporal spatial localization cell populations mediators during development. Eight-week old male C57Bl/6 mice were orthotopically inoculated with 1x106 cells tumor morphology, local systemic populations, plasma cytokines/chemokines assessed at day 0,...
Mesothelioma is an aggressive cancer with limited treatment options and a poor prognosis. Phytocannabinoids possess anti-tumour palliative properties in multiple cancers, however their effects mesothelioma are unknown. We investigated the anti-cancer potential mechanisms of action for several phytocannabinoids cell lines. A panel 13 inhibited growth human (MSTO H2452) rat (II-45) cells vitro, cannabidiol (CBD) cannabigerol (CBG) were most potent compounds. Treatment CBD or CBG resulted G0/G1...
Brain, lung and colon tissue experience deleterious immune-related adverse events when immune-oncological agents or radiation are administered. However, there is a paucity of information regarding whether the addition to immuno-oncological regimens exacerbates inflammatory response. We used murine model evaluate sub-acute damage systemic immune response in C57Bl/6 mice administered anti-programmed cell death protein 1 (αPD-1) immunotherapy alone combination with stereotactic fractionated 10...
Abstract Polyploidy is a common outcome of chemotherapies, but there conflicting evidence as to whether this source increased chemotherapy resistance and aggressive disease, or benign even favorable outcome. We have used Aurora B kinase (AURKB) inhibitors that efficiently promote polyploidy in many cell types investigate the fate polyploid cells. demonstrate AURKB inhibitor treatment cells loss RB p53 function causes them become hyper-polyploid, undergoing continuous rounds growth,...
Abstract Glioblastoma, the most aggressive form of glioma, has a 5-year survival rate <5%. While radiation and immunotherapies are routinely studied in murine Gl261 glioma model, little is known about its inherent immune response. This study quantifies temporal spatial localization cell populations mediators during development. Eight-week old male C57Bl/6 mice were orthotopically inoculated with 1×10 6 cells tumor morphology, local systemic populations, plasma cytokines/chemokines...
Abstract INTRODUCTION Glioma is a debilitating and early fatal cancer arising in the glial cells of brain. Glioblastoma, most aggressive form gliomas, has 5-year survival rate 5% with treatment options limited to surgery, radiotherapy or chemotherapy temozolomide. OBJECTIVE While radiation immunotherapies are routinely studied murine Gl261 glioma model, little known about its inherent immune response. In this study we quantified temporal spatial localisation cell populations mediators during...
Abstract Aurora B kinase has a major role in regulating progression through mitosis and partitioning the replicated genome at exit from cytokinesis. We have previously reported that A inhibitors selectively targeted HPV-driven tumours, HPV E7 oncogene is determinant of this selectivity. Another group shown sensitivity to inhibitor AZD2811 dependent on loss retinoblastoma protein (RB). Here we investigated outcomes inhibition using selective pan inhibitors. show promotes more cell death,...