A5046520625- Radiopharmaceutical Chemistry and Applications
- Radiation Therapy and Dosimetry
- Lanthanide and Transition Metal Complexes
- Metal complexes synthesis and properties
- Radioactive element chemistry and processing
- Boron Compounds in Chemistry
- Nuclear physics research studies
Universidad Nacional Autónoma de México
2016-2023
Instituto Politécnico Nacional
2020
In recent years, Copper-64 (T1/2 = 12.7 h) in the chemical form of copper dichloride ([64Cu]CuCl2) has been identified as a potential agent for PET imaging and radionuclide therapy targeting human transporter 1, which is overexpressed variety cancer cells. Limited biodistribution radiation dosimetry data available this tracer. The aim research was to determine estimate [64Cu]CuCl2, using whole-body (WB) scans healthy volunteers. Six volunteers were included study (3 women 3 men, mean age ±...
TOPAS-nBio was used to simulate, collision-to-collision, the complete trajectories of electrons in water generated during explicit simulation 64Cu decay. S-values and direct damage DNA were calculated representing cell (C) nucleus (N) with concentric spheres 5 μm 4 radius, respectively. The considered 'target'←'source' configurations, including surface (Cs) cytoplasm (Cy), were: C←C, C←Cs, N←N, N←Cy N←Cs. Ionization cluster size distributions also a cylinder immersed corresponding segment 10...
Purpose Targeted Radionuclide Therapy (TRT) with Auger Emitters (AE) is a technique that allows targeting specific sites on tumor cells using radionuclides. The toxicity of AE critically dependent its proximity to the DNA. aim this study quantify DNA damage and radiotherapeutic potential promising radionuclide copper-64 ( 64 Cu) incorporated into mammalian Monte Carlo track-structure simulations. Methods A cell nucleus model diameter 9.3 μm available in TOPAS-nBio was used. cellular...