A5004376325- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Multiple and Secondary Primary Cancers
- Liver Disease Diagnosis and Treatment
- Renal cell carcinoma treatment
- Neuroendocrine Tumor Research Advances
- Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Microbial Inactivation Methods
- Pediatric Hepatobiliary Diseases and Treatments
- RNA modifications and cancer
- Pancreatitis Pathology and Treatment
- Gastrointestinal Tumor Research and Treatment
- Organ Transplantation Techniques and Outcomes
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
Ministry of Health
2021-2025
Ministry of Health of the Russian Federation
2016-2025
Russian Cancer Research Center NN Blokhin
2015-2023
Pirogov Russian National Research Medical University
2017-2022
National Medical Research Center of Cardiology
2019-2021
Russian Academy of Sciences
2015
Academy of Medical Sciences
2015
Cancer Research Center
2015
Objective. To evaluate the diagnostic capability of intraoperative fluorescence lymphography (FLG) in detecting sentinel lymph nodes (SLN) and outflow pathways patients with biliary cancer (BC). Material methods. From April 2023 till March 2024, ten liver resections for BC were performed using FLG. We carried out standard node dissection additional removal (LN) that have accumulated indocyanine green (ICG). The lymphatic all frequency SLN invasion evaluated. Results. Ten included: five had...
AIM: to estimate early and late outcomes of multivisceral surgeries (MVS) with pancreaticoduodenalectomy (PD) for colorectal cancer.PATIENTS AND METHODS: the main group included 42 patients who underwent MVS PD cancer from January 2011 April 2024. The control 46 resection duodenum and/or head pancreas, i.e. without PD.RESULTS: controls were more likely have ECOG status 2-3 (44/46 (95.7%) vs. 33/42 (78.6%), p = 0.022), tumor stenosis colon/duodenum (31/46 (67.4%) 16/42 (38.1%), 0.006), less...
Aim . To investigate the immediate outcomes of multivisceral surgeries with pancreaticoduodenectomy for tumors various localizations. Materials and methods From January 2011 to April 2024, 251 patients underwent surgery different The control group consisted 832 who standard pancreaticoduodenectomy. Intergroup intragroup comparative analyses were performed. Results In main group, postoperative complications developed in 165 (65.7%), classified as ≥3 (severe complications) according...
Objective Many long noncoding RNAs (lncRNAs) are associated with liver cancers, mainly hepatocellular carcinoma (HCC) and to a smaller extent intrahepatic cholangiocarcinoma (CCA). Most of such lncRNAs show similar dysregulation patterns when the two types tumors compared, suggesting that these aberrations characteristic features tumor types. In present study, we aimed identify some candidate specifically CCA. Methods According The Cancer Genome Atlas data, chose LINC00941 , ABHD11-AS1 CASC8...
Введение. Лечение больных злокачественными новообразованиями у лиц старческого возраста представляет сложную проблему в виду общей коморбидности и сниженных резервных возможностей организма больного. Все это обусловливает высокие риски осложнений хирургического лечения послеоперационной летальности. Цель. Оценить переносимость панкреатодуоденальной резекции онкологическую обоснованность этой операции 75 лет старше. Материалы методы. В исследование включено 73 пациента возраста, которые с...
The prevalence of risk factors for HCC in the Russian population is reflected a significant potential growth morbidity. In absence active screening programs Federation, mortality from liver cancer groups and late diagnosis significantly exceeds growing Cancer care patients Federation at an early stage development represented by several clinical centers Moscow, St. Petersburg, regions. approved standards treatment HCC, surgical diseases primarily carried out; some clinics have experience...
Hepatocellular carcinoma (HCC) is the most common and aggressive type of malignant liver tumor. HCC progression depends significantly on its vascularization formation new blood vessels. Vascular endothelial growth factor A (VEGFA) a crucial regulator tumor components VEGF-induced cell signaling pathways are important targets therapeutical drugs that demonstrated highest efficiency in case advanced (sorafenib regorafenib). VEGFA expressed as set isoforms with different functional properties,...
Aim. To improve the outcomes in patients with pancreatic cancer by improving of surgical techniques and adjuvant therapy administration. Material Methods. 529 underwent treatment. Standard gastro pancreaticoduodenectomy was performed 85 patients, extended gastropancreaticoduodenectomy – 7 cases, modified standard 263, pancreatectomy 25, distal 107, cryodestruction еру tumor 42 patients. 161 (33%) simultaneous resection great vessels. Adjuvant carried out 335 Results. Morbidity varied from...
to determine the indications and evaluate early long-term outcomes of total pancreatectomy for pancreatic cancer.Treatment 29 patients who underwent one- two-stage different malignancies was analyzed.Median surgery duration intraoperative blood loss 280 min 2200 ml respectively. Postoperative complications were observed in 9 (31%) patients. There 2 (6.9%) deaths. 1- 3-year overall actual survival 61% 16% respectively case ductal adenocarcinoma. Median 18 months. Patients after primary...
To show the advisability, satisfactory tolerance and good analgesic effect of surgery for pancreatic ductal carcinoma with celiac trunk invasion.Distal subtotal pancreatectomy resection common hepatic artery was made in 21 patients.Early postoperative complications after distal occurred 10 (47.6%) patients. There no mortality. Resection edges including retroperitoneal space pancreas did not contain tumor cells according to histological examination. Complete obtained 100% patients...
The paper presents the results of various studies and meta-analyses which focus on assessing frequency formation clinically significant pancreatic fistulas in types pancreatic-digestive anastomoses. Pancreatodigestive anastomosis is not an independent predictive factor complications. None modern pancreatodigestive has proved its superiority. choice method based correct selection organ with stump connected surgeon’s experience skill forming anastomosis.
Biliary cancer is a group of tumors that develop from the epithelium intra- and extrahepatic bile ducts (cholangiocarcino-ma), as well gallbladder. For 10 years, chemotherapy based on combination gemcitabine cisplatin has remained standard first-line therapy in patients with locally advanced or metastatic biliary cancer, resulting median overall survival 11.7 months. With progression disease first line, effective options did not previously exist. Attempts to use various chemotherapeutic...
MEETING DATE: July 7, 2023 ITEMS ON THE AGENDA: 1. The role of the adjuvant atezolizumab plus bevacizumab in patients with hepatocellular carcinoma (HCC) at high risk recurrence following surgical resection or ablation. Profile patient who will benefit most from this therapy. 2. To evaluate prospects for therapeutic options early HCC Russia. Liver cancer remains a public health concern globally, an increasing trend number incident cases worldwide. Early, precise diagnosis and timely...
AIM: to assess early results of pancreatoduodenalectomy with colon resection for cancer.PATIENTS AND METHODS: a retrospective cohort two-center controlled study included 927 patients. The first group 95 patients after рancreatoduodenalectomy resection. second 832 who underwent without adjacent organs. was divided into two subgroups: the subgroup is malignant neoplasms — 42, other sites 53.RESULTS: and significantly more often assessed according ECOG 2–3 ASA 3 (52/95 (54.7%) vs 63/669 (9.4%),...
Background: New chemotherapy regimens (gemcitabine / nab-paclitaxel, FOLFIRINOX) have improved overall survival rates in ductal carcinoma, which has renewed the interest surgical treatment for isolated liver metastases. Aim: To identify role of surgery carcinoma pancreatic head with oligometastases. Methods: We retrospectively analyzed data from 490 patients morphologically verified two specialized centers, who had undergone pancreatoduodenectomy (PD) January 2011 to April 2024. In 21...
Aim . To describe the experience of multivisceral surgeries involving pancreaticoduodenectomy for tumors various localizations, performed in two Russian medical institutions. Materials and methods A retrospective study was conducted on outcomes 251 with institutions from January 2011 to April 2024. Results Tumors pancreatic head, duodenum large papilla were detected 180 cases (71.7%); colorectal 36 (14.3%); gastric 24 (9.6%); extrahepatic bile duct gallbladder 7 (2.8%); renal 3 (1.2%);...
Objective. To compare liver function assessments using Gd-EOB-DTPA-enhanced MRI and the gold standard hepatobiliary scintigraphy (HBS) in patients with bile duct diseases. Material methods. The investigation enrolled 18 (male/female = 11/7; age, 29–70 years, Klatskin tumor (n=16), epithelial dysplasia (n=1), intrahepatic cholangiolithiasis (n=1)) after biliary decompression, who underwent 21 paired MRIs 99mTc-mebrofenin HBS at a study interval of no more than 3 days. In same regions interest...
3559 Background: Recently, conflicting evidence has emerged showing the association of ctDNA level and cancer progression. The aim our study was development a method for detecting in plasma investigation prognostic value retention after surgery prospective way. Methods: This prospective, single-center, sample collection study; pts with early-stage malignancies different origin were included. Tumor somatic mutations determined by target sequencing DNA from FFPE tumor blocks. Sequencing...
Objective - to determine the role of ultrasound in diagnosis cholangiocarcinoma. Material and methods. Ultrasound examination conducted 120 cholangiocarcinoma patients. The results were confirmed by data from other research methods, biopsy, surgical palpation histopathological resected material. Results. most difficult is diagnose tumors distal portions common bile duct. Sensitivity ultrasound, X-ray CT, MRI, evaluation was: intrahepatic type 100%, 100%; hilus 69%, 75%, 86%, 92%; 37%, 42%,...