A5023016712- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Nanoparticle-Based Drug Delivery
- Ocular Surface and Contact Lens
- Hydrogels: synthesis, properties, applications
- Electrospun Nanofibers in Biomedical Applications
- Surfactants and Colloidal Systems
- Advancements in Transdermal Drug Delivery
- Polymer Surface Interaction Studies
- 3D Printing in Biomedical Research
- Advanced Polymer Synthesis and Characterization
- biodegradable polymer synthesis and properties
- Antimicrobial agents and applications
- Bone Tissue Engineering Materials
- RNA Interference and Gene Delivery
- Polysaccharides Composition and Applications
- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Chromatography
- Microfluidic and Capillary Electrophoresis Applications
- Wound Healing and Treatments
- Protein purification and stability
- Silk-based biomaterials and applications
- Bacterial biofilms and quorum sensing
- Nanoplatforms for cancer theranostics
- Rheology and Fluid Dynamics Studies
Universidade de Santiago de Compostela
2016-2025
Instituto de Investigación Sanitaria de Santiago
2016-2020
University of Buenos Aires
2008-2015
Consejo Nacional de Investigaciones Científicas y Técnicas
2008-2015
Organismo Autónomo Parques Nacionales
2015
National Research Council
2011
Methodist University
2009
Massachusetts Institute of Technology
2007
Supratek Pharma (Canada)
2005
Aligarh Muslim University
1998
Cyclosporine is an immunosuppressant agent approved for the treatment of dry eye disease and used off-label other ocular pathologies. Its formulation bioavailability present a real challenge due to large molecular weight (1.2 kDa), high lipophilicity, low water solubility. The aim work was develop aqueous micellar efficient cyclosporine delivery tissues, using water-soluble derivative vitamin E (TPGS: d-α-tocopheryl polyethylene glycol 1000 succinate) poloxamer 407 (Pluronic ®F127) as...
Hydrogels with high affinity for carbonic anhydrase (CA) inhibitor drugs have been designed trying to mimic the active site of physiological metallo-enzyme receptor. Using hydroxyethyl methacrylate (HEMA) as backbone component, zinc methacrylate, 1- or 4-vinylimidazole (1VI 4VI), and N-hydroxyethyl acrylamide (HEAA) were combined at different ratios reproduce in hydrogels cone-shaped cavity CA, which contains a Zn2+ ion coordinated three histidine residues. 4VI resembles functionality better...