A5088955056- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Viral Infections and Immunology Research
- Cardiovascular Function and Risk Factors
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiovascular and exercise physiology
- Cardiovascular Effects of Exercise
- Pulmonary Hypertension Research and Treatments
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Treatments and Studies
- Renal cell carcinoma treatment
- Transplantation: Methods and Outcomes
- Colorectal and Anal Carcinomas
- Pericarditis and Cardiac Tamponade
- Renal and Vascular Pathologies
- RNA regulation and disease
- Vascular Anomalies and Treatments
- Lymphadenopathy Diagnosis and Analysis
- Vascular anomalies and interventions
- Radiation Dose and Imaging
- Organ Donation and Transplantation
- Cytomegalovirus and herpesvirus research
Ospedale Papa Giovanni XXIII
2021-2025
University of Milano-Bicocca
2021-2023
University of Milan
2020-2023
University of Siena
2009-2018
IRCCS Policlinico San Donato
2015
University of Palermo
2009
Abstract Portal hypertension resulting from non-cirrhotic extrahepatic portal vein obstruction is a cause of severe morbidity related to variceal bleeding in children. In patients not eligible for Meso-Rex bypass, rescue interventions refractory have traditionally included surgical porto-systemic shunts or transjugular intrahepatic shunt (TIPS), which alter the normal physiology liver perfusion and expose children long-term complications. recanalization recently described technique aims...
Thymidylate synthase (TS) is a tumor-associated enzyme critical for DNA replication and main 5′-fluorouracil (5′-FU) target. TSPP/VAC1 multi-arm trial phase-Ib program aimed to investigate the toxicity biomodulatory activity of poly-epitope-peptide vaccine TS (TSPP) in cancer patients (pts). Here, we present results TSPP/VAC1/arm C evaluate TSPP combination with chemo-immunotherapy pretreated metastatic colo-rectal (mCRC) pts. Twenty-nine pts, 14 males 15 females, received poly-chemotherapy...
Abstract Background Chronic total occlusion (CTO) of the portal vein is one main causes hypertension, which may result in life-threatening complications often managed by interventional radiology (IR). The aim this study to report innovative experience with percutaneous revascularization therapy management CTO paediatric and adult patients. Materials methods From January 2020 December 2023 consecutive patients severe hypertension resulting from who underwent attempts at recanalization were...
Embolisation of the parenchymal tract is a key step after any other transhepatic or transplenic percutaneous portal vein catheterization since eventual venous bleeding difficult to control and may require surgical management. Different techniques have been proposed perform embolisation. The aim this study compare safety efficacy different haemostasis tract.All interventional procedures with access (excluding ipsilateral embolisation) from January 2010 July 2020, in two tertiary hospitals,...
Purpose: To evaluate technical and clinical outcomes of intraoperative (laparoscopic/laparotomic) microwave ablation on HCC. Materials Methods: This is a retrospective single-center study evaluating consecutive patients treated for very early/early-stage HCC with from 1 July 2017 to 30 June 2023. In these patients, percutaneous US-guided approach was excluded due the nodule’s suboptimal visibility or harmful location liver resection deep position adherences. Data about stage, surgical...
Background Cardiac strain represents an imaging biomarker of contractile dysfunction. Purpose The purpose this study was to investigate the diagnostic value cardiac obtained by feature-tracking magnetic resonance (MR) in acute myocarditis. Materials and Methods MR examinations 46 patients with myocarditis preserved ejection fraction at phase follow-up were analyzed along healthy age- sex-matched controls. Global circumferential global radial calculated for each examination, myocardial edema...
To report procedural data and outcomes of a novel image guidance technique, CT renal arteriography (CTRA), performed to target ablate small intraparenchymal tumors.We retrospectively analyzed 2 patients undergoing CTRA-guided ablation for 3 tumors, from February March 2023. We previously evaluated tumor visibility with US/CEUS, in all cases conspicuity was poor, whereas contrast-enhanced (CECT) clearly depicted hypervascular nodules. Our primary endpoint CTRA-guidance feasibility ablation,...
Arterioportal fistulas (APFs) are uncommon vascular abnormalities with a heterogeneous etiology. In pediatric orthotopic liver transplantation (OLT), APFs frequently iatrogenic, following percutaneous interventions. The aim of this study was to report the 10-year experience tertiary referral center for OLT in interventional radiological (IR) and conservative management acquired APFs. A retrospective search performed retrieve patients (<18 years old) diagnosis APF at color Doppler...
Abstract Purpose Pediatric liver transplant surgery is burdened by arterial complications whose endovascular treatment not standardized. We report the outcomes of a cohort pediatric recipients with hepatic artery treated endoluminal procedures. Materials and Methods From December 2019 to 2022, consecutive transplanted patients who underwent were reviewed. The analysis included: type complication (occlusion, stenosis, pseudoaneurysm); onset (acute = < 15 days, subacute 15–90 late > 90...
Duplications of the alimentary tract are rare malformations, and ileum is most involved intestinal tract. During fetal life, they usually occasional findings may be asymptomatic until adulthood. We present clinical case volvulus on ileal cystic duplication diagnosed by ultrasound during prenatal follow-up. Diagnosis was made at our center 23 weeks gestational age, which confirmed with MRI. follow-up, 36 + 4 weeks, presence dilated loops reduction peristalsis shown ultrasound, so that,...
Background: Inflow-sensitive inversion recovery (IFIR) is a recently introduced technique to perform unenhanced magnetic resonance angiography (MRA). The purpose of our study determine the accuracy IFIR-MRA in evaluation upper abdominal arteries, compared standard MRA and computed tomography (CTA). Materials Methods: Seventy patients undergoing abdomen Magnetic Resonance Imaging (MRI) different clinical settings were enrolled. MRI protocol included an sequence that was intra-individually by...
Meeting abstracts Thymidylate synthase (TS) is a tumor-associated-enzyme crucial for DNA replication and inhibited by 5′-fluorouracil. TSPP previously characterized anticancer poly-epitope peptide vaccine to TS ( Correale P, JNCI 2005 97:1437 ). TSPP/VAC-1 three-arm dose-finding Phase-
Background: Aortic stenosis (AS) is clinically characterized by dyspnea and intolerance to exercise. Clinical interpretation of such symptoms often difficult due the advanced age AS patients. We aimed at identifying cardiac determinants exercise in (Aortic Vmax >3 m/s). Methods results: performed cardiopulmonary test (CPET) simultaneously combined with echocardiography 43 patients referred for functional assessment. Severe were evaluated because not certainly related valvular disease....
Background: the oxygen uptake (VO2) response to exercise, measured during cardiopulmonary exercise testing (CPET), has prognostic value in heart failure (HF). The increase VO2 is due cardiac output (CO) and arterial-mixed venous content difference (C(a-v)O2). How much (C(a-v)O2) contribute may be estimated by CO/VO2 ratio. Aim: To study functional phenotype associated with ratio at peak HF reduced ejection fraction (HFrEF). Methods: 104 HFrEF patients (mean age 64±11 y, male %, ischemic...
Background: Speckle tracking (ST) analysis is a reliable methodology that allow to quantify myocardial functional properties better than traditional echo parameters. Purpose: We considered heart failure reduced ejection fraction (HFrEF) population with the aim investigate how 2D ST on right ventricle at peak exercise could help stratify different cardiopulmonary testing (CPET) phenotypes. Methods: 36 HFrEF patients (mean age 69±12; male 69%; NYHA I-II-III-IV 19-17-25-5 %) underwent maximal...
Background: The ratio between the duration of right ventricular (RV) systole and diastole (S:D ratio) has been proposed as an index RV performance in a pediatric population with pulmonary arterial hypertension whom it may predict prognosis functional capacity. In heart failure (HF) S:D provide relevant insights exercise response. Aim: to analyze correlation rest peak cardiac parameters HFrEF. Methods: 94 HFrEF patients (mean age 66±11 y, male 70%, ischemic etiology 71%, mean LVEF 34±9%)...