A5032835042- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Tracheal and airway disorders
- Cancer and Skin Lesions
- Lung Cancer Research Studies
- Cancer, Lipids, and Metabolism
- HER2/EGFR in Cancer Research
- Lysosomal Storage Disorders Research
- Celiac Disease Research and Management
- TGF-β signaling in diseases
- Atherosclerosis and Cardiovascular Diseases
- Polysaccharides and Plant Cell Walls
- Cholesterol and Lipid Metabolism
- Cancer-related gene regulation
- Complement system in diseases
- Renin-Angiotensin System Studies
- Peptidase Inhibition and Analysis
- Phagocytosis and Immune Regulation
- Receptor Mechanisms and Signaling
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Oral and Maxillofacial Pathology
- Immune cells in cancer
Cedars-Sinai Medical Center
2022-2024
Los Angeles Medical Center
2023
Abstract Aims The metabolic failure of macrophages to adequately process lipid is central the aetiology atherosclerosis. Here, we examine role macrophage angiotensin-converting enzyme (ACE) in a mouse model PCSK9-induced Methods and results Atherosclerosis mice was induced with AAV-PCSK9 high-fat diet. Animals increased ACE (ACE 10/10 mice) have marked reduction atherosclerosis vs. WT mice. Macrophages from both aorta peritoneum express PPARα profoundly altered phenotype lipids characterized...
Fibroepithelial lesions of the breast (FELs) are a heterogeneous group neoplasms exhibiting histologic spectrum ranging from fibroadenomas (FAs) to malignant phyllodes tumors (PTs). Despite published criteria for their classification, it is common such exhibit overlapping features, leading subjective interpretation and interobserver disagreements in diagnosis. Therefore, there need more objective diagnostic modality aid accurate classification these guide appropriate clinical management. In...
The pathogenesis of atherosclerosis is defined by impaired lipid handling macrophages which increases intracellular accumulation. This dysregulation triggers the accumulation apoptotic cells and chronic inflammation contributes to disease progression. We previously reported that mice with increased macrophage-specific angiotensin-converting enzyme, termed ACE10/10 mice, resist in an adeno-associated virus-proprotein convertase subtilisin/kexin type 9 (AAV-PCSK9)-induced model. due metabolism...
Context.— Robotic-assisted navigation bronchoscopy (R-ANB) is used to target peripheral pulmonary nodules that are difficult biopsy using conventional approaches. Frozen sections requested confirm these lesions have been localized and/or diagnose neoplasms can be immediately resected. Objective.— To estimate diagnostic concordance between frozen section diagnosis (FSD) and formalin-fixed tissue (FFTD) in biopsies obtained with R-ANB, calculate the sensitivity specificity of FSD FFTD for a...
Fibroepithelial lesions of the breast encompass a broad spectrum from fibroadenomas and their variants to phyllodes tumors, including clinical range benign, borderline, malignant. Classification this neoplasms has historically currently been based purely on morphology, although nomenclature shifted over years largely due significant histologic overlap that exists primarily within cellular borderline malignant tumor categories. A review current diagnostic challenge, proposed ancillary studied...
Alpha-mannosidosis is a rare genetic lysosomal storage condition leading to the systemic buildup of oligomannoside. Clinical presentation and associated conditions, as well full extent histopathologic changes with this disease process, are not fully understood.We present case an 8-year-1-month old patient persistent anemia who was initially diagnosed Celiac before ultimately being alpha-mannosidosis. As part his diagnostic work-up, duodenal bone marrow biopsies were examined by pathology....
Abstract Fibroepithelial lesions of the breast (FELs) are a heterogeneous group neoplasms exhibiting histologic spectrum ranging from fibroadenomas (FAs) to malignant phyllodes tumors (PTs). Despite published criteria for their classification, it is common such exhibit overlapping features, leading subjective interpretation and inter-observer disagreements in diagnosis. Therefore, there need more objective diagnostic modality aid accurate classification these guide appropriate clinical...