A5101925727- Total Knee Arthroplasty Outcomes
- Nutrition and Health in Aging
- Knee injuries and reconstruction techniques
- Shoulder Injury and Treatment
- Sports injuries and prevention
- Muscle Physiology and Disorders
- Body Composition Measurement Techniques
- Shoulder and Clavicle Injuries
- Spine and Intervertebral Disc Pathology
- Bone Metabolism and Diseases
- Osteoarthritis Treatment and Mechanisms
- Tendon Structure and Treatment
- MicroRNA in disease regulation
- Musculoskeletal pain and rehabilitation
- Cerebral Palsy and Movement Disorders
- Cancer-related molecular mechanisms research
- Cardiac, Anesthesia and Surgical Outcomes
- Hernia repair and management
- Bone fractures and treatments
- Orthopedic Surgery and Rehabilitation
- Clinical Nutrition and Gastroenterology
- Bone health and treatments
- Hip and Femur Fractures
- Adipokines, Inflammation, and Metabolic Diseases
- Bone and Joint Diseases
Xiangya Hospital Central South University
2016-2025
Central South University
2016-2025
National Clinical Research
2023-2025
Weatherford College
2023
Creative Commons
2023
Second Affiliated Hospital of Shantou University Medical College
2020-2023
Shantou University
2020-2023
Sichuan Mianyang 404 Hospital
2021
Shenzhen Second People's Hospital
2020
Rush University Medical Center
2015
Abstract Foreign body reactions (FBR) to implants seriously impair tissue‐implant integration and postoperative adhesion. The macrophage, owing its phenotypic plasticity, is a major regulator in the formation of inflammatory microenvironment; NF‐κB signaling also plays vital role process. It hypothesized that phosphorylation exerts proinflammatory FBR polylactide membranes (PLA‐M) First, vitro vivo experiments show PLA‐M induces macrophages, leading M1 polarization release factors....
Abstract As the world population structure has already exhibited an inevitable trend of aging, technical advances that can provide better eldercare are highly desired. Knee osteoarthritis, one most common age‐associated diseases, be effectively treated via total knee arthroplasty (TKA). However, patients suffering from recovery process due to inconvenience in post‐hospital treatment. Here, a portable, modular, and wearable brace for self‐assessment TKA patients’ rehabilitation is reported....
Osteosarcoma (OS) is an aggressive malignant mesenchymal neoplasm amongst adolescents. The aim of the present study was to explore various modes action that miR-379 has on proliferation, migration, and invasion human OS cells. achieves this by targetting eukaryotic initiation factor 4GII (EIF4G2). Human cell lines U2OS MG-63 were selected assigned into blank, mimics, mimic negative control (NC), inhibitors, inhibitor NC, EIF4G2 shRNA, + shRNA group. expression mRNA detected utilising...
Osteosarcoma (OS) is the most common cancer of bone. Chemotherapy commonly used for clinical treatment OS. However, chemoresistance to cisplatin [also known as diamminedichloridoplatinum (II) (DDP)] a major obstacle OS therapy, underlying mechanism which not fully understood. The present study aimed investigate role microRNA (miR)-199a-5p in regulation DDP cells. Reverse transcription-quantitative polymerase chain reaction demonstrated that expression level miR-199a-5p was significantly...
Chronic nonhealing wounds pose a significant challenge to healthcare system because of its tremendous utilization resources and time heal. It has well-deserved reputation for reducing the quality life those affected represent substantial economic burden overall. Earthworms are used as traditional Chinese medicine, have been applied pharmacologically clinically since long in China. However, there is paucity data regarding wound healing effects. Therefore, we investigated effect earthworm...
Sarcopenia, an age-related degenerative disease, seriously affects the health and quality of life elder. The research sarcopenia has changed dramatically around world. This article aims to analyze global trends in this field over past 20 years."Sarcopenia" was used as search term retrieve relevant publications from WOS PubMed databases. Co-occurrence, literature coupling, co-citation, co-author analysis were performed by using software VOS viewer. We analyzed last years different aspects,...
Objectives. This study is undertaken to investigate the relation between osteopontin (OPN) and Wnt5a expression in progression pathogenesis of osteoarthritis (OA). Methods. 50 cartilage tissues from knee OA patients normal controls were divided into four groups severe, moderate, minor, lesions based on modified grading system Mankin. Immunohistochemistry real-time PCR utilized analyze OPN articular cartilage. Besides, relations severity explored. Results. could be identified groups' tissues....
Abstract During cell differentiation, growth, and development, cells can respond to extracellular stimuli through communication channels. Pannexin (Panx) family connexin (Cx) are two important types of channel-forming proteins. Panx contains three members (Panx1-3) is expressed widely in bone, cartilage muscle. Although there no sequence homology between Cx family, they exhibit similar configurations functions. Similar Cxs, the key roles Panxs maintenance physiological functions...
Abstract Sarcopenia presenting a critical challenge in population‐aging healthcare. The elucidation of the interplay between brain structure and sarcopenia necessitates further research. aim this study is to explore casual association sarcopenia. Linkage disequilibrium score regression (LDSC) was conducted estimate genetic correlations; MR then performed causal relationship Brain imaging‐derived phenotypes (BIDPs) three sarcopenia‐related traits: handgrip strength, walking pace, appendicular...
Abstract Background Recent epidemiological studies have linked the central nervous system (CNS) to osteoarthritis (OA), suggesting that targeting CNS could offer new therapeutic strategies. This study aimed validate correlation between brain structures and OA risk, identify key causal genes by integrating transcriptomic proteomic data with genome-wide association (GWAS). Methods We analyzed summary statistics from 826,690 participants. Using linkage disequilibrium score regression (LDSC)...