A5051742916- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- Liver Disease and Transplantation
- HIV/AIDS Research and Interventions
- Hepatitis Viruses Studies and Epidemiology
- HIV Research and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immune Cell Function and Interaction
- HIV, Drug Use, Sexual Risk
- Mycobacterium research and diagnosis
- Plant-based Medicinal Research
- Immune Response and Inflammation
- HIV-related health complications and treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Homelessness and Social Issues
- Healthcare Systems and Challenges
- Poisoning and overdose treatments
- Lymphadenopathy Diagnosis and Analysis
- melanin and skin pigmentation
- Pharmacological Receptor Mechanisms and Effects
- Vaccine Coverage and Hesitancy
- Global Public Health Policies and Epidemiology
- Alcohol Consumption and Health Effects
Beth Israel Deaconess Medical Center
2015-2025
Harvard University
2012-2025
PureTech (United States)
2025
Hadassah Medical Center
2003-2016
University of Massachusetts Chan Medical School
2016
Office of International Affairs
2016
Tufts University
2013
Johns Hopkins Medicine
2013
Johns Hopkins University
2013
Johns Hopkins Hospital
2013
OBJECTIVES: Noninvasive markers of liver fibrosis correlate with the stage fibrosis, but have not been widely applied to predict liver-related mortality. METHODS: We assessed ability two indices aspartate aminotransferase (AST)-to-platelet ratio index (APRI) and Fib-4, extracellular matrix metabolism, hyaluronic acid (HA) YKL40, mortality in a prospective cohort hepatitis C virus (HCV)-infected individuals without HIV coinfection. These were compared established prognostic scores,...
We are entering a new era in the treatment of hepatitis C virus (HCV) infection and almost all patient groups high-income countries have potential to be cured with all-oral, highly potent combinations direct-acting antiviral drugs. Soon main barrier curing C, even wealthy countries, will high price these all-oral regimens. The gulf between advances HCV drug development access for individual patients greater low- middle-income (LMIC) where 80% global burden mortality exists. Ensuring that...
Pegylated interferon α (PEG IFN-α) improves sustained virological response rates in chronic hepatitis C, but neither its role acute C nor the biologic basis for action has been defined. This prospective study assessed efficacy of PEG IFN-α treatment relation to kinetics virus (HCV)-specific CD4 + T cell responses during therapy and follow-up. Forty subjects with proven who received either plus ribavirin (n = 20) or monotherapy 24 weeks addition 14 untreated were prospectively followed. Serum...
Hepatitis C virus (HCV)-specific T-cell responses are rarely detected in peripheral blood, especially the presence of human immunodeficiency (HIV) coinfection. Based on recent evidence that T-regulatory cells may be increased chronic HCV, we hypothesized functional blockade regulatory could raise HCV-specific and might differentially regulated setting HIV Three groups subjects were studied: HCV monoinfected, HCV-HIV coinfected, healthy controls. Frequencies T specific for peptides derived...
Noninvasive markers of hepatic fibrosis hold great promise to stage liver and monitor disease progression. To date, few studies have assessed the performance currently available in HIV-infected cohorts. The aim current study was compare diagnostic characteristics a number noninvasive populations hepatitis C virus (HCV)-infected patients with without HIV infection.A sample 97 subjects (40 HCV/HIV-coinfected, 57 HCV-infected) undergoing biopsy as part an ongoing prospective cohort evaluated....
The kinetics of intrahepatic hepatitis C virus (HCV)-specific CD4+ T cell responses and their role in progression fibrosis have not previously been characterized. Subjects with HCV/Schistosoma mansoni coinfection a more rapid HCV liver than do those infection alone. present prospective longitudinal study compared the histology, HCV-specific peripheral proliferative responses, cytokines (enzyme-linked immunospot) 48 subjects unresolved acute or without S. coinfection, at 6-10 months after end...
Health-related quality of life (HRQOL) is diminished in patients infected with both hepatitis C virus (HCV) and human immunodeficiency (HIV), but the effect HIV/HCV coinfection on HRQOL unknown. We compared urban coinfected that either HCV or HIV alone. then 3 groups a US population sample, adjusting for demographic characteristics. group was statistically similar to alone, had significantly decreased than did adjusted population. Using multivariate techniques, we determined age,...
Acute hepatitis C virus (HCV) is typically defined as new viremia and antibody seroconversion. Rates immunologic correlates of clearance have therefore been based on only in individuals who initially had an response. We sought to characterize the immunological patients with acute their sexual contacts. prospectively determined CD4(+) CD8(+) cytotoxic T-lymphocyte responses index HCV contacts developed infection, either or without spontaneous clearance, well those never viremia. Responses...
Hepatitis B virus (HBV) infection continues to threaten millions of lives across the globe, despite universal vaccination efforts. Current guidelines for screening, vaccination, and treatment are complex have left too many people undiagnosed or improperly managed. Antiviral therapy has been shown significantly reduce incidence liver-related complications, including liver cancer. However, complexity existing can make it difficult identify which patients target treatment, recommendations that...
Introduction The pathophysiology of respiratory complications in post-acute sequelae SARS CoV-2 infection (PASC) is poorly understood but a high incidence progressive pulmonary fibrosis was anticipated. Deupirfenidone (LYT-100) selectively deuterated form pirfenidone which retains antifibrotic and anti-inflammatory activity with improved tolerability. This study evaluated the safety efficacy deupirfenidone PASC patients complications. Methods Global, double-blind, randomized...
<title>Abstract</title> <bold>Background: </bold>The antifibrotic therapies, pirfenidone and nintedanib, have been approved since 2014 for idiopathic pulmonary fibrosis (IPF), but in the United States only a quarter of people living with IPF ever exposed to an antifibrotic. Understanding burden consequences disease its treatment from perspective may facilitate improved education outreach them their providers. <bold>Methods:</bold> Qualitative interviews explored perspectives on diagnosis...
Persons with human immunodeficiency virus (HIV) and hepatits C (HCV) coinfection are at increased risk for progression to cirrhosis compared persons HCV alone, but the reasons this unclear. In chronic HCV, mechanism of liver injury is presumed be due HCV-specific T cell destruction hepatocytes, so it paradoxical that immunosuppressed hosts have higher rates fibrosis progression. We examined intrahepatic cellular immune responses antigens determine whether there were qualitative or...
The antifibrotic therapies, pirfenidone and nintedanib, have been approved since 2014 for idiopathic pulmonary fibrosis (IPF), but in the United States only a quarter of people living with IPF ever exposed to an antifibrotic. Understanding burden consequences disease its treatment from perspective may facilitate improved education outreach them their providers. Qualitative interviews explored perspectives on diagnosis management IPF. Transcripts were analyzed derive themes topics,...
ABSTRACT Receipt of a broad-spectrum cephalosporin is strong risk factor for isolation cephalosporin-resistant Enterobacter species, and yet the from other β-lactams hydrolyzed by group 1 β-lactamases has not been well characterized. We compared conferred cephalosporins to that piperacillin-tazobactam, alone or in combination with an aminoglycoside fluoroquinolone. A retrospective cohort was monitored treatment onset until strain isolated patient discharged. There were 447 patients...
ObjectiveCellular immune responses are difficult to detect in the peripheral blood of persons with chronic hepatitis C virus (HCV) infection. We sought determine whether T cell were present liver patients human immunodeficiency (HIV) and HCV coinfection MethodsT cells expanded from liver-biopsy samples 10 coinfected HIV (median CD4+ count, 456 cells/mm3) 8 infected alone. CD8+ detected by use a modified enzyme-linked immunospot (ELISpot) assay recombinant vaccinia virus, ELISpot proteins...
Sofosbuvir (SOF)- or simeprevir (SIM)-containing regimens are highly effective for treating chronic hepatitis C virus (HCV) infection. These regimens, however, expensive. Most payers have implemented prior authorization (PA) requirements to ensure that patients who can benefit most priority these medications. While many Medicaid programs limit access those with advanced disease members do not active substance use disorder (SUD), the Massachusetts (MassHealth) Primary Care Clinician (PCC)...