A5016667204- Bladder and Urothelial Cancer Treatments
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Urinary and Genital Oncology Studies
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Global Cancer Incidence and Screening
- Amino Acid Enzymes and Metabolism
- Urological Disorders and Treatments
- Hepatitis C virus research
- Nutrition, Health and Food Behavior
- Stroke Rehabilitation and Recovery
- Cancer Immunotherapy and Biomarkers
- Ethics in Clinical Research
- Drug-Induced Hepatotoxicity and Protection
University of Maryland, Baltimore
2023-2024
Memorial Sloan Kettering Cancer Center
2019-2023
Brown University
2023
University of Maryland Medical Center
2023
Tufts University
2023
New York Proton Center
2020
Nanjing Medical University
2019
Jiangsu Cancer Hospital
2019
New York University
2015
We report oncologic outcomes for men with Grade Group 1 prostate cancer managed active surveillance at a tertiary center.A total of 2,907 patients were between 2000 and 2017, whom 2,664 had disease. Patients recommended confirmatory biopsy to verify eligibility followed semiannually specific antigen, digital rectal examination review symptoms. Magnetic resonance imaging was increasingly used in recent years. Biopsy repeated every 2 3 years or after sustained antigen increase changes magnetic...
We studied the risk of metastatic prostate cancer development in men with Grade Group 2 disease managed active surveillance at Memorial Sloan Kettering Cancer Center.A total 219 had between 2000 and 2017. Biopsy was performed every to 3 years, or upon changes magnetic resonance imaging, specific antigen level digital rectal examination. The primary outcome distant metastasis. Kaplan-Meier method used estimate treatment-free survival.Median age diagnosis 67 years (IQR 61-72), median 5 ng/ml...
Identification of inherited germline variants can guide personalized cancer screening, prevention, and treatment. Pathogenic likely pathogenic (P/LP) in predisposition genes are frequent among patients with locally advanced or metastatic urothelial carcinoma, but their prevalence significance non-muscle-invasive bladder (NMIBC), the most common form is understudied.
INTRODUCTION AND OBJECTIVE: Clinically localized urothelial carcinoma (UC) requires multi-modality treatment including neoadjuvant chemotherapy (NAC). Unfortunately use of NAC remains low suggesting that physicians feel utility in clinically UC is minimal despite level 1 evidence. Upstaging cT1-T2 to non-organ-confined (NOC) pathological stage >T3 or N+ at radical cystectomy (RC) common. Biomarkers clinical tools stratify patients who may have NOC disease are limited. Prior studies, the...
Introduction: Visual abnormalities and manual motor control have been studied extensively after stroke, but an understanding of oculomotor post-stroke has not. Recent studies revealed that in visually guided reaches arm movements are planned during eye movement execution, which may contribute to increased task complexity. In fact, healthy controls reaches, the onset is delayed, its velocity reduced, endpoint errors larger relative isolated movements. Our objective this experiment was examine...
Supplementary Data from Inherited Germline Cancer Susceptibility Gene Variants in Individuals with Non–Muscle-Invasive Bladder
Supplementary Data from Inherited Germline Cancer Susceptibility Gene Variants in Individuals with Non–Muscle-Invasive Bladder
<div>AbstractPurpose:<p>Identification of inherited germline variants can guide personalized cancer screening, prevention, and treatment. Pathogenic likely pathogenic (P/LP) in predisposition genes are frequent among patients with locally advanced or metastatic urothelial carcinoma, but their prevalence significance non–muscle-invasive bladder (NMIBC), the most common form is understudied.</p>Experimental Design:<p>Germline analysis was conducted on paired...
<div>AbstractPurpose:<p>Identification of inherited germline variants can guide personalized cancer screening, prevention, and treatment. Pathogenic likely pathogenic (P/LP) in predisposition genes are frequent among patients with locally advanced or metastatic urothelial carcinoma, but their prevalence significance non–muscle-invasive bladder (NMIBC), the most common form is understudied.</p>Experimental Design:<p>Germline analysis was conducted on paired...
Introduction: Acute liver failure (ALF) is defined by injury causing synthetic dysfunction (coagulopathy) and encephalopathy within 26 weeks from insult in patients without preexisting disease. ALF must be distinguished acute injury—which does not exhibit encephalopathy—due to the difference management potential need for transplant (LT) ALF. We present a case of with concern caused congestive hepatopathy due chronic thromboembolic pulmonary hypertension (CTEPH). Case Description/Methods: A...
<title>Abstract</title> <bold>Background & Aims:</bold> Pre-liver transplant (LT) functional status is an important determinant of prognosis post LT. There insufficient data on how affects outcomes recipients based the specific etiology liver disease. We stratified LT by disease to evaluate effects post-LT in each subgroup. <bold>Methods</bold>: 2005-2019 United Network for Organ Sharing (UNOS) Standard Transplant Analysis and Research (STAR) was used select patients with transplant. A...
INTRODUCTION AND OBJECTIVE: Emerging data have shown that patients with locally advanced and metastatic urothelial cancer frequently harbor rare germline variants in predisposition genes, particularly DNA damage response (DDR) genes. The prevalence of such non-muscle invasive bladder (NMIBC), the most common form cancer, has not been thoroughly studied. METHODS: Patients NMIBC who were unselected for inherited syndromes prospectively enrolled a protocol molecular profiling tumor-normal pairs...
INTRODUCTION AND OBJECTIVE: High-grade non-muscle invasive bladder cancer (NMIBC) is treated with intravesical BCG immunotherapy. Unfortunately, 40% of patients develop recurrence a subset progressing. Identification genomic alterations associated response to could identify novel approaches prevent or delay recurrence. To explore tumor evolution under the selective pressure therapy, we utilized targeted exon capture sequencing (IMPACT) compare collected pre- and post-BCG treatment. METHODS:...