A5076571329- Inflammasome and immune disorders
- Immune Response and Inflammation
- Bone and Dental Protein Studies
- Extracellular vesicles in disease
- Fluoride Effects and Removal
- RNA Research and Splicing
- Oral microbiology and periodontitis research
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Mesenchymal stem cell research
- Fault Detection and Control Systems
- Advanced Battery Technologies Research
- Cancer-related Molecular Pathways
- Biomarkers in Disease Mechanisms
- NF-κB Signaling Pathways
- Neonatal Health and Biochemistry
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- Autoimmune and Inflammatory Disorders Research
- Connexins and lens biology
- Bone Metabolism and Diseases
- Circadian rhythm and melatonin
- Influenza Virus Research Studies
- Dietary Effects on Health
- Machine Learning in Bioinformatics
National Natural Science Foundation of China
2014-2022
Nihon University
2018-2021
Shenyang Medical College
2021
Xi'an University of Technology
2019
Periodontal pathogens initiate various diseases and induce inflammatory host responses. The activation of inflammasomes triggers caspase-1 interleukin (IL)-1β-mediated pyroptosis via gasdermin D (GSDMD). Differentiated embryo chondrocyte 2 (Dec2) is a transcription repressor that controls the expression genes involved in innate immune However, effects Dec2 on inflammasome-induced periodontal tissues remain elusive. This study aimed to characterize contribute P. gingivalis lipopolysaccharide...
MicroRNAs are emerging as critical post-transcriptional modulators in bone remodeling, regulating the functions of osteoblasts and osteoclasts. Intercellular crosstalk between osteoclasts is mediated by miR-21 that controls homeostasis response, providing potential targets for maintenance osteoblast function. The aim this study was to investigate effects on function, explore underlying mechanism. Increased alkaline phosphatase (ALP) activity accelerated matrix mineralization observed mouse...
Macrophages play crucial roles as early responders to bacterial pathogens and promote/ or impede chronic inflammation in various tissues. Periodontal macrophage-induced pyroptosis results physiological pathological inflammatory responses. The transcription factor Dec2 is involved regulating immune function processes. To characterize the potential unknown role of innate system, we sought elucidate mechanism that may alleviate macrophage periodontal inflammation.Porphyromonas gingivalis...
Transcriptional regulation of autophagy depends on the transcription factors coordinated inflammatory feedback mechanism. Here, we provide a comprehensive functional characterization periodontal ligament fibroblasts (PDLFs) treated with Porphyromonas gingivalis lipopolysaccharide (LPS), aiming to reveal previously unappreciated biological changes and investigate how factor differentiated embryonic chondrocytes 2 (Dec2)-deficient environment influences function in nflamed human PDLFs.
Autophagy is a highly conserved intracellular digestion process that degrades damaged proteins and organelles but the biological roles of autophagy in pathological aspects oral tissues remain largely unknown. We sought to elucidate function autophagy, especially its interplay with apoptosis oxidative stress, toxicity induced by exposure 5 mM sodium fluoride (NaF). Human cementoblasts (HCEM-2) culture were exposed NaF for min, after which cell viability assessed using MTS assay an Annexin...
Intracellular signaling complexes of the innate immune system orchestrate development inflammation. Porphyromonas gingivalis is a commensal bacterium that induces periodontal pyroptosis. The transcription factor Dec1 can regulate expression inflammatory molecules. In this study, we investigated whether deficiency activates/represses Caspase-1 and/or Gasdermin-D in pyroptosis, resulting release proinflammatory mediator interleukin-1β. human ligament fibroblasts (HPDLFs) treated with P....
With the increasing demand of medical research, disease animal models are widely used to study mechanism human initiation and development, drug screening, treatment evaluation. The development different kinds is reviewed. advantages China gap between world in this field analyzed. This review covers fields cancer, neurological diseases mental health, infectious immune diseases, cardiovascular metabolic screening. main future directions pointed out funding related 'disease models' by National...
Pro-inflammatory cytokines activate the fibroblasts that reside in periodontal tissues and polymorphonuclear leukocytes (PMNs) are responsible for a substantial part of destruction caused by host response. The resident anaerobic bacteria interact with inflammatory reactions leading to hypoxic environment pocket. Expression transcription factor Differentiated Embryonic-Chondrocytes Expressed Gene 1 (DEC1) is regulated hypoxia, growth factors cytokines. To reveal biological relevance hypoxia...
State of health (SOH) estimation plays an important role in battery management system. This problem is addressed by introducing a second-order RC equivalent circuit model (ECM) and square root extended kalman filter (SREKF) this work. According to the ECM, ohmic resistance (R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> ) which represents SOH molded as state vector, lithium obtained using internal relationship between ohm SOH. Then...
Abstract Background: Gingival recession and concomitant alveolar bone resorption are hallmarks of periodontal diseases excessive fluoride intake has some deleterious effects on teeth, soft tissues. Autophagy is a highly conserved intracellular digestion process that degrades damaged proteins organelles but the biological roles autophagy in pathological aspects oral tissues remain largely unknown. We sought to elucidate function autophagy, especially its interplay with apoptosis oxidative...
Oral squamous cell carcinomas (OSCCs) are the most common type of oral cancer and patients with OSCC have a poor prognosis low 5year survival rate.Longer is correlated lower expression DNA Damage Inducible Transcript 4 (DDIT4) from certain types tissue.The primary object this study was to explore associated role DDIT4 in human cancers.HSC -3 carcinoma cells were used examine effect knockdown by siRNA silencing efficiency evaluated quantitative realtime PCR (qRT -PCR) .DNA microarray analysis...
Autonomous rhythmicity of clock genes controls the circadian rhythm and endogenous rhythms regulates various biochemical, physiological, biological processes,with a periodicity about 24 h. Entrainment cells detects distinct patterns oscillation for genes. Although disruptions have been implicated in cancer development, altered human oral remains largely unknown. Here we show that, upon entrainment by serum shock, cultured epithelial cell line, HSC-3, maintain an inner oscillator, with key...
comes and clinical diagnosis for OSCC patients remains unsatisfactory.Thus, a better understanding of the disease biology OSCCs is needed to improve survival outcomes intervention.BCL2/adenovirus E1B 19 kDainteracting protein 3 (BNIP3) belongs Bcl -2 family encoded in human chromosome 10q26.3.BNIP3 procell death can heterodimerize with (3, 4) .It has been demonstrated that BNIP3 induces cell
优化学科布局是国家自然科学基金委员会进行科学基金深化改革的三大核心任务之一。医学科学部面向医学科学研究的发展需求，通过优化调整医学申请代码体系，支撑医学科学发展的前沿领域和新兴学科，增强对薄弱学科、短板学科的引领和推动，推进医学研究范式变革，促进知识与应用的融通。结合医学各分支学科领域的中长期发展规划及“十四五”发展规划战略研究，面向科学前沿鼓励自由探索，聚焦重大需求引导解决核心科学问题，明确各学科领域的未来资助方向、资助政策及优先发展领域。通过优化调整申请代码体系、前瞻部署优先发展领域、统筹推进各类专项项目，持续优化医学学科布局，努力构建符合新时代医学科学发展和人才培养需求的科学基金资助管理体系，促进医学科技创新，推动我国医学创新发展。