A5101908437- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Nigella sativa pharmacological applications
- RNA Interference and Gene Delivery
- Genetics and Neurodevelopmental Disorders
- Electromagnetic Fields and Biological Effects
- Attention Deficit Hyperactivity Disorder
- Nicotinic Acetylcholine Receptors Study
- Nutrition, Genetics, and Disease
- Nerve injury and regeneration
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Smoking Behavior and Cessation
- Extracellular vesicles in disease
- Alzheimer's disease research and treatments
- Autism Spectrum Disorder Research
- RNA regulation and disease
- Medicinal Plants and Neuroprotection
- Migraine and Headache Studies
- Hydrogen's biological and therapeutic effects
- Functional Brain Connectivity Studies
- Angiogenesis and VEGF in Cancer
- Selenium in Biological Systems
- Telomeres, Telomerase, and Senescence
Gaziantep University
2015-2025
Mersin Üniversitesi
2014-2017
Pamukkale University
2016
Gazi University
2012
MicroRNAs (miRNA) play a paramount role in growth, differentiation, proliferation and cell death by suppressing one or more target genes. However, their interaction with radiofrequencies is still unknown. The aim of this study was to investigate the long-term effects radiofrequency radiation emitted from Wireless Fidelity (Wi-Fi) system on some miRNA brain tissue.The carried out 16 Wistar Albino adult male rats dividing them into two groups such as sham (n = 8) exposure 8). Rats group were...
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia. However, biomarkers that require testing in brain tissue pose formidable practical barrier to AD diagnostic innovation. MicroRNAs (miRNAs) are responsible for control gene expression at posttranscriptional level essential function neuronal networks survival. miRNA can impact regulation APP (amyloid beta A4 precursor protein), PSEN1 (presenilin 1), PSEN2 2), BACE1 (beta-secretase 1)...
Purpose: We still do not have any information on the interaction between radiofrequency radiation (RF) and miRNA, which play paramount role in growth, differentiation, proliferation cell death by suppressing one or more target genes. The purpose of this study was to bridge gap investigating effects long-term 900 MHz mobile phone exposure some miRNA brain tissue.Materials methods: carried out 14 Wistar Albino adult male rats dividing them into two groups: Sham (n = 7) 7). Rats group were...
Alzheimer's disease (AD) is a neurodegenerative characterized by progressive memory loss and cognitive decline, with hallmark pathologies related to amyloid beta (Aβ) TAU. Natural phytochemicals show promise for drug discovery fill the current therapeutic innovation gap in AD. This study investigated effect of cucurbitacin E (CuE), one bioactive components Ecballium elaterium, on TAU fibril formation okadaic acid-induced AD rats. In randomized design, we assigned 30 female Sprague Dawley...
Parkinson's disease (PD) is a frequently occurring neurodegenerative motor disorder adversely impacting global health. There paucity of biomarkers and diagnostics that can forecast susceptibility to PD. A new research frontier for PD pathophysiology the study variations in microRNA (miRNA) expression whereby miRNAs serve as "upstream regulators" gene relation functioning dopamine neuronal pathways. Leucine-Rich Repeat Kinase 2 (LRRK2) studied Little known about ways which targeting LRKK2...
Aim: Obsessive–compulsive disorder (OCD) is a characterized by the presence of obsessions and/or compulsions. Although etiology and pathogenesis remains unknown, several theories about OCD development have been proposed, many researchers believe that it caused both genetic environmental factors. In current study, our aim was to investigate miRNA levels in OCD. Methods: we evaluated miR18a-5p, miR22-3p, miR24-3p, miR106b-5p, miR107, miR125b-5p, miR155a-5p child adolescent patients. The...
Alcohol dependence (AD) is a neuropsychiatric disorder to which both genetic and environmental factors contribute. Especially, multiple are promising explain the etiology of AD. microRNAs (miRNAs) members family noncoding small RNAs, thought be responsible for altered gene expression in disorders. We hypothesized that single nucleotide polymorphisms (SNPs) miRNA biogenesis pathway may result dysregulation levels inside cell. The aim this study was test an association between variants AD...
Alzheimer disease (AD) is a common complex neurodegenerative disorder accounting for nearly 50% to 70% of dementias worldwide. Yet the current diagnostic options AD are limited. New innovation strategies focusing on novel molecules and pathways sorely needed. In this connection, microRNAs (miRNAs) conserved small noncoding RNAs that regulate posttranscriptional gene expression vital neuronal development its functional sustainability. Conceivably, biological responsible biogenesis miRNAs...
Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental that negatively affects different areas of life. We aimed to evaluate the associations between Val66Met polymorphism brain-derived neurotrophic factor (BDNF) and ADHD assess effect BDNF on neurocognitive profile clinical symptomatology in ADHD.Two hundred one cases 99 typically developing subjects (TD) ages 8 15 years were involved study. All evaluated using complete neuropsychological battery, Child Behavior Checklist,...
Biomarker potential of hsa-miR-145-5p in peripheral whole blood
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination and axonal degeneration. Abnormal expression microRNAs (miRNAs) plays an important role in MS pathology. In this cohort study, differential four miRNAs (hsa-miR-155-5p, hsa-miR-9-5p, hsa-miR-181a-5p, hsa-miR-125b-5p) was investigated 69 individuals, including 39 patients (relapsing-remitting (RRMS), n = 27; secondary progressive (SPMS), 12) 30 healthy controls. silico...
To investigate the role of matrix metalloproteinases (MMPs), MMP-9 and MMP-2, vascular endothelial growth factor (VEGF) in metastasis their relationship with survival. Early is most common cause lung cancer death. Angiogenesis basement membrane damage are necessary for invasion tumoral cells. VEGF, involved angiogenic activity, MMPs, destruction, important cancer. Materials methods: Using immunohistochemistry analysis, we evaluated MMP-9, VEGF expressions paraffin specimens from 91 patients...
Objective: To investigate the neurometabolite level changes according to synapsin III gene rs133945G>A and rs133946C>G polymorphisms by using magnetic resonance spectroscopy (MRS) in patients with attention-deficit hyperactivity disorder (ADHD). Methods: Fifty-seven adults diagnosed ADHD were recruited for study. The participants examined single-voxel 1 H MRS when medication naïve 30 minutes after oral administration of 10 mg methylphenidate (Mph). Those who had been on a stimulant...