A5035509789- Prostate Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Glioma Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Brain Metastases and Treatment
- Radiation Dose and Imaging
- Radiomics and Machine Learning in Medical Imaging
- Sarcoma Diagnosis and Treatment
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Bladder and Urothelial Cancer Treatments
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Radiation Therapy and Dosimetry
- Meningioma and schwannoma management
- Management of metastatic bone disease
- Economic and Financial Impacts of Cancer
- Ocular Oncology and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Urologic and reproductive health conditions
- Health Systems, Economic Evaluations, Quality of Life
- Urinary and Genital Oncology Studies
- Epigenetics and DNA Methylation
- Urinary Bladder and Prostate Research
Memorial Sloan Kettering Cancer Center
2013-2025
New York Proton Center
2024
NYU Langone Health
2016-2018
New York University
2010-2018
Tufts Medical Center
2014-2017
Cornell University
2017
Brown University
2014-2017
Tufts University
2015-2017
Rhode Island Hospital
2015-2016
NYU Langone’s Laura and Isaac Perlmutter Cancer Center
2016
// Kasthuri Kannan 1,4 , Akiko Inagaki 2 Joachim Silber Daniel Gorovets Jianan Zhang Edward R. Kastenhuber Adriana Heguy 4 John H. Petrini Timothy A. Chan 3,4 and Jason T. Huse 1 Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA Molecular Biology, 3 Radiation Oncology, Human Oncology Pathogenesis Program, Correspondence: Huse, email: Keywords : glioma, astrocytoma, IDH, ATRX, whole-exome sequencing Received October 01, 2012, Accepted 09, Published 11, 2012...
Diffuse gliomas represent the most prevalent class of primary brain tumor. Despite significant recent advances in understanding glioblastoma [World Health Organization (WHO) IV], its malignant subtype, lower grade (WHO II and III) glioma variants remain comparatively understudied, especially light their notable clinical heterogeneity. Accordingly, we sought to identify characterize clinically relevant molecular subclasses diffuse astrocytic gliomas.We conducted multidimensional profiling,...
Summary Haemophagocytic lymphohistiocytosis ( HLH ) is a syndrome of uncontrolled immune activation that has gained increasing attention over the past decade. Although classically known as familial disorder children caused by mutations affect cytotoxic T‐cell function, an acquired form in adults now widely recognized. This often seen setting malignancy, infection or rheumatological disorders. We performed retrospective review across 3 tertiary care centres and identified 68 with . The...
Trimethylation of histone 3 lysine 9 (H3K9me3) is a marker repressed transcription. Cells transfected with mutant isocitrate dehydrogenase (IDH) show increased methylation residues, including H3K9me3, because inhibition demethylases by 2-hydroxyglutarate. Here, we evaluated H3K9me3 and its association IDH mutations in 284 gliomas. H3K9 was significantly associated oligodendrogliomas. Moreover, 72% World Health Organization grade II 65% III oligodendrogliomas showed combined positivity 1p19q...
Abstract Background We investigate the impact of gender, race, and socioeconomic status on diagnosis management bladder cancer in United States. Methods utilized National Cancer Database to stratify cases urothelial cell carcinoma as early (Tis, Ta, T1), muscle invasive (T2–T3, N0), locally advanced (T4, N1–3), metastatic. Multivariate binomial multinomial logistic regression analyses identified demographic characteristics associated with stage at receipt cancer‐directed therapies. Odds...
Pediatric sarcomas provide a unique diagnostic challenge. There is considerable morphologic overlap between entities, increasing the importance of molecular studies in diagnosis, treatment, and identification therapeutic targets. We developed validated genome-wide DNA methylation based classifier to differentiate osteosarcoma, Ewing's sarcoma, synovial sarcoma.DNA status 482,421 CpG sites 10 11 15 osteosarcoma samples were determined using Illumina Infinium HumanMethylation450 array. random...
352 Background: The incidence of regional lymph node metastases at diagnosis is approximately 15%. Androgen deprivation therapy (ADT) with radiotherapy (RT) remains a standard treatment option, but long-term effects and outcomes are understudied. Methods: Data was retrospectively collected from 304 subjects radiographic node-positive prostate cancer treated RT 2014-2024. Covariates include use androgen receptor signaling inhibitors (ARSI), brachytherapy boost to primary disease in prostate,...
Purpose: Although hydrogel spacer placement (HSP) minimizes rectal dose during prostate cancer radiotherapy, its potential benefit for modulating toxicity could depend upon the achieved prostate-rectal separation. We therefore developed a quality metric associated with reduction and late among patients treated stereotactic body radiotherapy (SBRT).Materials Methods: A consisting of interspace (PRI) measurements from axial T2-weighted MRI simulation images was applied to 42 men enrolled on...
Prostate cancer is the second most common among men globally and number of cases expected to double from 2020 2040. A greater understanding health system factors that can be leveraged improve prostate control may guide planning in anticipation growing global burden cancer. This ecological cross-sectional study made use recent available national metrics for countries with incidence mortality estimates International Agency Research on Cancer (IARC). IARC data represent updated as April 2025....
Abstract Background Data for proton therapy in high‐risk prostate cancer (HRPC) are limited. Using the Proton Collaborative Group prospective registry, we evaluated outcomes HRPC patients treated with therapy. Methods A totsl of 605 men localized from 8/2009 to 3/2019 at nine institutions were selected. Outcomes examined included freedom progression (FFP), metastasis free survival (MFS), overall (OS), and toxicity. Multivariable cox/binomial regression models used assess predictors FFP...
To identify predictors for prolonged survival free from salvage whole brain radiation therapy (WBRT) in patients with metastases treated stereotactic radiosurgery (SRS) as their initial radiotherapy approach.Patients SRS 2001 to 2013 at our institution were identified. without WBRT was typically offered 1-4 metastases, Karnofsky performance status ≥70, and life expectancy ≥3 months. Three hundred eight met inclusion criteria analysis. Medical records reviewed patient, disease, treatment...
Many patients treated with stereotactic radiosurgery (SRS) alone as initial treatment require 1 or more subsequent salvage therapies. This study aimed to determine if commonly used strategies are associated differing risks of radiation necrosis (RN). All upfront SRS for brain metastases at our institution were retrospectively analyzed. Salvage details obtained failures. Patients who underwent repeat the same lesion excluded. RN was determined based on pathological confirmation advanced...
Early encounters with palliative care (PC) can influence health-care utilization, clinical outcome, and cost.To study the effect of timing PC on brain metastasis patients at an academic medical center.All diagnosed metastases from January 2013 to August 2015 a single institution inpatient and/or outpatient records available for review (N = 145).Early was defined as having encounter within 8 weeks diagnosis metastases; late after diagnosis. Propensity score matched cohorts early (n 46) were...