A5055040361- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Psoriasis: Treatment and Pathogenesis
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Infectious Diseases and Tuberculosis
- Vasculitis and related conditions
- Healthcare Systems and Public Health
- Renal Diseases and Glomerulopathies
- Immunodeficiency and Autoimmune Disorders
- Osteomyelitis and Bone Disorders Research
- Orthopedic Infections and Treatments
- Toxin Mechanisms and Immunotoxins
- Monoclonal and Polyclonal Antibodies Research
- Genetic Neurodegenerative Diseases
- Cerebral Palsy and Movement Disorders
- Neurological disorders and treatments
- Therapeutic Uses of Natural Elements
- Inflammatory Myopathies and Dermatomyositis
- Systemic Sclerosis and Related Diseases
- Renal and Vascular Pathologies
- Parkinson's Disease and Spinal Disorders
- Medical and Biological Sciences
Clinical Hospital No. 8
2021-2025
Regional Health
2024
Tyumen Regional Oncological Dispensary
2019-2022
Tyumen State Medical University
2020
Rice University
2012
The Tyumen Regional Rheumatology Center has gained experience in the use of interleukin-6 inhibitor olokizumab (OKZ) treatment patients with rheumatoid arthritis (RA). Objective: to evaluate efficacy and safety OKZ therapy RA real-life clinical practice. Material methods . analysis included 75 a confirmed diagnosis who were prescribed at dose 64 mg every 4 weeks. All underwent standard laboratory examination concomitant diseases recorded. results evaluated after 1, 6 12 months therapy. A...
To study and compare the clinical imaging characteristics of psoriatic arthritis (PsA) in men women.
NiSpAR is a non-interventional, multicenter study whose aim was to describe cohort of patients with non-radiological axial spondyloarthritis (nr-axSpA) and approaches its diagnosis in the Russian Federation. Material methods. The involved 20 research centers different regions work consisted two phases: retrospective data collection 12 months before enrolment prospective observation whom nr-axSpA confirmed (104 weeks). included 272 who met inclusion exclusion criteria (Full Analysis Set,...
The efficacy and safety of levilimab (LVL) in patients with active rheumatoid arthritis (RA) has been confirmed controlled clinical trials. This article presents the results a preliminary analysis non-interventional observational study LVL RA patients. Objective: to evaluate treatment real-world practice. Materials methods. HELIOS is retrospective-prospective, multicenter, retention rate therapy Patients received medical care, including LVL, according routine practice for Russian...
Psoriatic arthritis (PsA) is a heterogeneous inflammatory associated with psoriasis (Ps); it belongs to the group of spondyloarthritis and accompanied by damage both spine peripheral joints, as well development enteritis dactylitis. In addition skin joint damage, PsA has numerous comorbid conditions that are pathogenetically related underlying disease, such bowel disease (IBD) autoimmune eye cardiovascular diseases, obesity metabolic syndrome, diabetes, osteoporosis, malignancies, mental...
Aim. To study the relationship between obesity, cardiometabolic disorders and disease activity in patients with psoriatic arthritis (PsA) real practice. Materials methods. The Russian register included 614 PsA [female 331 (54%)/283 (46%)]. Average age 45.20.52 years, duration 5.70.27 psoriasis 15.710.56 years. Patients underwent examination, body mass index (BMI), according to DAPSA, cDAPSA, analysis of concomitant diseases were assessed. divided into 3 groups depending on BMI (kg/m2):...
Objective: to describe the portrait of a patient with rheumatoid arthritis (RA) in real clinical practice, assess disease activity from point view physician and patient, functional status, quality life (QOL), efficiency therapy performed. Patients methods . The investigation enrolled 976 RA patients cohort TERMINAL-I multicenter study, who, when visiting rheumatologist, independently assessed QOL using computer system (the «Computer Terminals SelfAssessment for Rheumatic Diseases» project)....
BACKGROUND: Chronic multiple nonbacterial osteomyelitis is an orthopaedic autoinflammatory disease of bones and joints unclear aetiology, characterised by the formation foci osteitis refractory to antibiotic therapy surgical treatment, occurring predominantly before age 18 years. Data on treatment adult chronic are limited due orphan character rarity its onset in adults. AIM: To present data efficacy conservative after one-year follow-up. MATERIALS AND METHODS: 12 patients aged years older...
The ability to balance is a prerequisite sitting, standing, and walking requires complicated physiological coordination. disruption of any components the equilibrioceptive, proprioceptive, or visual systems can significantly handicap balance, such as in some cases cerebral palsy, spina bifida, arthrogryposis, cystic fibrosis, many other diseases injuries. Unfortunately, patients with damaged brain function disorder at root problem cannot typically be treated but, physical therapy braces...
Background: Tofacitinib (TF) is an oral Janus kinase inhibitor approved for PsA treatment. It has demonstrated comparable to ADA efficacy in RCT reducing clinical symptoms 1,2 . There currently no data concerning comparative effectiveness of TF and practice. The Russian RegisTry (RU-PsART) collected from 43 rheumatology centers the Federation. Objectives: study responses or over a period 6 months (mo) treatment patients (pts) with active real Methods: 77 (M/F=43/34) pts fulfilling CASPAR...
Background The goal of psoriatic arthritis (PsA) treatment is achievement remission (REM) or Low Disease Activity (LDA) by DAPSA. impact comorbidities, especially obesity, metabolic syndrome on PsA activity and biological response are shown in some registry [1]. Obesity, hypertension Charlson Comorbidity Index ≥1 prognostic factors for poorer outcome rates [2]. But influence number comorbidities has not been fully studied real practice Objectives To evaluate the DAPSA pts Methods 528...
Background: Limited data are available on retention rates of biologic therapy in psoriatic arthritis (PsA) patients (pts) with axial involvement. It has been shown that the subset pts prevalent involvement (AS versus PsA and AxSpA PsA) a longer duration anti-TNF-α-therapy was observed as compared to peripheral [1]. Objectives: To compare without routine clinical practice. Methods: 731 according CASPAR criteria were included study. Data collected from 43 rheumatology clinics over various...
The association between malignancy and dermato-/polymyositis has been largely described confirmed by numerous epidemiological studies. temporal relationship the two pathologic conditions can vary: may occur before, at same time or following diagnosis of myositis. Myositis debut requires a doctor high vigilance in terms likelihood developing cancer. article presents clinical features paraneoplastic myopathies observation.
Background: PsA patients (pts) have an increased risk of cardiovascular (CV) and metabolic (Met) disorders due to the combination inflammation prevalence traditional CV factors. Only limited data are available on Russian pts. Data was collected from 25 rheumatology clinics Federation Objectives: study, in clinical practice, obesity its association with activity, CV/Met comorbidities PROs Methods: 614 (M/F=331(54%)/283(46%) pts fulfilling CASPAR criteria were included RU-PsART cohort. Mean...
Background: Obesity is a common comorbidity of psoriasis and PsA. It connected to low-grade inflammation it has negative impact on the response therapies. Although high prevalence obesity been shown in whole number epidemiology observational studies, its relationship PsA activity less investigated. In RU-PsART registry data was collected from 43 rheumatology centers Russian Federation Objectives: evaluate association as well therapy real clinical practice Methods: 614 (M/F=331(54%)/283(46%)...
Background Psoriatic arthritis (PsA) is a disease with multidomain clinical presentation such as arthritis, enthesitis, dactylitis, spondylitis and psoriasis (PsO). [1]. Enthesitis key feature of PsA significant impact on function, quality life choice treatment [2]. There are limited real-world studies the characteristics patients (pts) enthesitits. Objectives To compare pts without enthesitis. Methods 603 (M/F=278/326) according to CASPAR criteria were examined. Data was collected from 6...
Background Psoriatic arthritis (PsA) is a chronic, musculoskeletal inflammatory disease that develops in up to 30% of patients (pts) with psoriasis (PsO). There are conflicting data about correlations between skin and joint severity from the observational cohort [1, 2]. But it’s very important for clinical phenotyping treatment PsA pts. Objectives evaluate association PsO activity. Methods 778 (M/F=357/421) pts fulfilling CASPAR criteria were included into Russian rheumatological cohort....
Background: Psoriatic arthritis (PsA) is heterogeneous in its clinical presentation and disease course, but many patients (pts) develop a destructive form of arthritis. Psoriasis (PsO) precedes by an average 7 years. [1]. Theory transition from PsO to PsA has been proposed recently [2]. But association between skin severity joint are still unclear. Objectives: evaluate bone erosion, duration, nail pts based on data practice (RU-PsART cohort). Methods: 737 (M/F=350/387) fulfilling the CASPAR...
Background: Limited data are available regarding the burden of nail disease in psoriatic arthritis (PsA). The latest show that involvement PsA patients (pts) is associated with significantly more severe status (1). Objectives: To analyze, clinical practice, association psoriasis activity, quality life, and work productivity pts. Methods: 588 pts (M/F–277 /311) according to CASPAR criteria were included study. Data collected from 43 rheumatology clinics different regions Russian Federation....
Background: Psoriatic Arthritis (PsA) is a multifaceted disease with various clinical domains. A number of composite indices has been developed recently [1, 2]. DAPSA ( D isease ctivity in PS oriatic rthritis) the valid instrument for assessment PsA activity focused on peripheral arthritis. But other factors can influence and haven’t studied yet. Objectives: to identify that are associated based data from RU-PsART cohort. Methods: 117 (M/F=63(54%)/54(46%)) patients (pts) active fulfilling...