A5059996212- Particle physics theoretical and experimental studies
- Protein Structure and Dynamics
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Atomic and Subatomic Physics Research
- Dark Matter and Cosmic Phenomena
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Advanced Proteomics Techniques and Applications
- Quantum Chromodynamics and Particle Interactions
- Particle Accelerators and Free-Electron Lasers
Oregon State University
2019-2021
Hub proteins participate in cellular regulation by dynamic binding of multiple within interaction networks. The hub protein LC8 reversibly interacts with more than 100 partners through a flexible pocket at its dimer interface. To explore the diversity partner pool, we screened for using proteomic phage display library composed peptides from human proteome, which had no bias toward known motif. Of identified hits, validated 29 isothermal titration calorimetry. peptides, 19 were entirely...
ABSTRACT All life depends on the reliable translation of RNA to protein according complex interactions between machinery and sequence features. While ribosomal occupancy codon frequencies vary across coding regions, well-established metrics for computing potential do not capture such positional dependence. Here, we investigate positiondependent usage bias ( PDCUB ), which dynamically accounts position proteincoding signals embedded within regions. We demonstrate existence in human...