A5076361831- Bone Tissue Engineering Materials
- biodegradable polymer synthesis and properties
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Orthopaedic implants and arthroplasty
- Additive Manufacturing and 3D Printing Technologies
- Collagen: Extraction and Characterization
- Mesenchymal stem cell research
- Graphene and Nanomaterials Applications
- Dental Implant Techniques and Outcomes
- Periodontal Regeneration and Treatments
- Diamond and Carbon-based Materials Research
- Tissue Engineering and Regenerative Medicine
- Metal and Thin Film Mechanics
- Connective tissue disorders research
- Osteoarthritis Treatment and Mechanisms
- Titanium Alloys Microstructure and Properties
- Spectroscopy Techniques in Biomedical and Chemical Research
- Pluripotent Stem Cells Research
- Laser Applications in Dentistry and Medicine
- Wound Healing and Treatments
- Innovative Microfluidic and Catalytic Techniques Innovation
- Bone fractures and treatments
- AI in cancer detection
- Bone and Dental Protein Studies
Universidade Federal do ABC
2016-2025
Hospital Samaritano de São Paulo
2023
Biomedica (Czechia)
2022
National Laboratory of Energy and Geology
2017
Centro Universitário Fundação Santo André
2014
Centro Regional de Derechos Humanos y Justicia de Género, Corporación Humanas
2012-2014
Universidade Estadual Paulista (Unesp)
2007-2008
Universidade Estadual de Campinas (UNICAMP)
2000-2007
Universidade de Passo Fundo
2004
Institute of Cell Biology
2001-2004
Chitosan is soluble in diluted acid solutions and can easily form films by casting. However, residual neutralization should be performed for biomedical applications what may compromise physical mechanical properties of the films. Thus, plasticizers added to improve these properties. The aim this study was characterize morphological, barrier properties, besides evaluate vitro cytotoxicity sorbitol-plasticized NaOH-Na2CO3 neutralized chitosan membranes skin substitute application. Scanning...
We evaluated the viability of Vero and osteogenic differentiation potential mesenchymal stem cells (MSCs) cultured on alpha-TCP-RL, SiTCP-RL, SiTCP-RC bioceramic scaffolds. Viability MSCs were by MTT assay. The morphological pattern two cell types was analyzed SEM. functional activity a cytochemical assay Alizarin red staining ALP activity. In assay, showed high in extract cytotoxicity test but low direct contact test. SEM analysis spread with irregular flattened morphology different...
C57Bl/6J mice are the gold standard animal model of diet-induced obesity. These animals become obese with higher adiposity, blood fasting glucose, triglycerides, and total cholesterol when fed a high-fat diet (HFD). Conversely, FVB/N mouse line is thought to be resistant obesity, low or no weight gain adiposity in response HFD. In this study, we investigated whether susceptible metabolic disorder that promoted by Biometric parameters chemistry were analyzed chow Glucose insulin sensitivity...
Abstract Collagen has been extensively described as a beneficial material in bone tissue engineering due to its biocompatibility, biodegradability, low antigenicity, and high tensile strength. However, collagen scaffolds their pure form have some drawbacks improvements the physical, chemical, biologic properties of are necessary overcome those inadequacies. Recently, selective hydrolysis carboxyamides asparagine glutamine residues employed increase number negative sites enhance piezoelectric...
Abstract: This study evaluates the effect of poly(L‐lactic acid) (PLLA) and poly(hydroxybutyrate‐cohydroxyvalerate) (PHBV) bioabsorbable polymers their blends on induction alteration cell growth pattern in vitro. Vero cells were cultured PLLA, PHBV, different (100/0, 60/40, 50/50, 40/60, 0/100). The adhesion assay showed that best results obtained with (60/40, 50/50) blends. Scanning electron microscopy (100/0) (60/40) samples grew a round morphology preferentially porous areas. (50/50) had...
Abstract Fibrous scaffolds have become popular in tissue engineering (TE) due to their morphological resemblance extracellular matrix components. While electrospinning is the most common technique field, solution blow spinning an emerging with great potential. One of its many advantages that it can produce aligned fibers a very simple experimental setup. This work aimed fabricate poly(ε‐caprolactone) mats and compare them nonaligned ones. For that, samples were produced using three...
Biomateriais poliméricos são desenvolvidos para uso como substitutos de tecidos danificados e/ou estimular sua regeneração. Uma classe biomateriais os biorreabsorvíveis, compostos que se decompõem tanto in vitro quanto vivo. São empregados em necessitam um suporte temporário recomposição tecidual. Dentre vários polímeros destacam-se alfa-hidróxi ácidos, entre eles, diferentes composições do poli(ácido lático) (PLA), o poli(L-ácido (PLLA), poli(D-ácido (PDLA), poli(DL-ácido (PDLLA), além...
We investigated the potential use of 3D hybrid membrane: poly (ε-caprolactone) (PCL) mesh using rotary jet spinning with subsequent chitosan (CH) coating. The morphological examinations by scanning electron microscopy (SEM) were proved efficiency this technique on obtaining relative homogeneous PCL fiber mats (15,49±4,1µm), high surface porosity (1,06±0,41µm) and effective CH feasibility allowed solvent evaporation during process; fact was verified differential calorimetry (DSC), indeed also...
Tissue engineering represents a promising alternative for reconstructive surgical procedures especially the repair of bone defects that do not regenerate spontaneously. The present study aimed to evaluate effects elastin matrix (E24/50 and E96/37) incorporated with hydroxyapatite (HA) or morphogenetic protein (BMP) on process in distal metaphysis rat femur. groups were: control group (CG), hydrolyzed at 50°C/24h (E24/50), E24/50 + HA (E24/50/HA), BMP (E24/50/BMP), 37°C/96h (E96/37), E96/37...
This study aimed to evaluate in vitro and vivo polymeric membranes obtained by a rotary jet-spinning process for the repair of critical bone defects calvaria Wistar rats, future use tissue engineering. Experimental sample collections were performed on 30, 60 90th postoperative days, analyses histomorphometric, immunohistochemistry, western blotting. Reducing inflammatory infiltrate all groups experimental periods, angiogenesis 30th day did not show any difference between groups, 60th day, 5%...
Abstract: In the last few years, demand has increased for research on polymeric materials, which can be used as substitutes injured tissues and organs or to improve their regeneration. this work, we studied poly( l ‐lactic acid) (PLLA) membranes, a resorbable biomaterial, were either dense had different pore diameters (less than 45 μm, between 180 250 350 μm), in relation stimulation of cell adhesion, growth, differentiation vitro. We Vero cells, fibroblastic line, biological model...
Diabetes mellitus can cause various diseases, including loss of bone mineral density as a characteristic manifestation osteoporosis. In this condition, is more vulnerable to pathologic fractures that be treated by implantation biomaterial grafts. The aim study was evaluate the osteogenic capacity hydroxyapatite implanted into defects in skull nonobese diabetic mice. Fifteen mice were divided 3 groups: control (nondiabetic), spontaneously diabetic, and receiving insulin replacement applied...