Agnieszka Skrobała

ORCID: 0000-0003-0539-9041
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Research Areas
  • Advanced Radiotherapy Techniques
  • Radiation Dose and Imaging
  • Radiation Therapy and Dosimetry
  • Medical Imaging Techniques and Applications
  • Advances in Oncology and Radiotherapy
  • Brain Metastases and Treatment
  • Lung Cancer Diagnosis and Treatment
  • Radiomics and Machine Learning in Medical Imaging
  • Prostate Cancer Diagnosis and Treatment
  • Cancer Diagnosis and Treatment
  • Effects of Radiation Exposure
  • Advanced X-ray and CT Imaging
  • Breast Cancer Treatment Studies
  • Radiation Detection and Scintillator Technologies
  • Glioma Diagnosis and Treatment
  • Prostate Cancer Treatment and Research
  • Management of metastatic bone disease
  • Intellectual Property Rights and Media
  • Radiation Effects and Dosimetry
  • Digital Radiography and Breast Imaging
  • Cancer and Skin Lesions
  • Electronic Health Records Systems
  • Meningioma and schwannoma management
  • Nuclear and radioactivity studies
  • Gastric Cancer Management and Outcomes

Poznan University of Medical Sciences
2014-2025

Greater Poland Cancer Center
2015-2025

Centrum Onkologii
2003-2024

Meditest
2021

Although the effects of high dose radiation on human cells and tissues are relatively well defined, there is no consensus regarding low very doses organism. Ionizing has been shown to induce gene mutations chromosome aberrations which known be involved in process carcinogenesis. The induction secondary cancers a challenging long-term side effect oncologic patients treated with radiation. Medical sources like intensity modulated radiotherapy used cancer treatment computed tomography...

10.1515/raon-2017-0044 article EN cc-by-nc-nd Radiology and Oncology 2017-11-01

Abstract Introduction: Radiotherapy using the CyberKnife (CK) system for treating eye tumors requires tracking skull movements and immobilizing eye. This study aims to develop a custom algorithm noninvasive position monitoring in CK framework. Material Methods: Retrospective data were analyzed from 13 patients treated with over five fractions. Eye immobilization was achieved two guides above patient’s head, black dot as fixation Camera recording used analyze pupil movements. A Python-based...

10.2478/pjmpe-2025-0009 article EN Polish Journal of Medical Physics And Engineering 2025-03-01

<title>Abstract</title> This educational review provides a comprehensive overview of adaptive radiation therapy (ART), an advanced approach to adjusting radiotherapy plans in response anatomical or physiological changes during treatment. It classifies ART into three methods, i.e. offline, online, and real-time, distinguished by the timing plan modifications relative treatment session. The emphasises importance monitoring discrepancies between planned delivered doses through imaging...

10.21203/rs.3.rs-6528751/v1 preprint EN Research Square (Research Square) 2025-05-05

Our understanding of low dose, out-of-field radiation and their radiobiological effects are limited, in part due to the rapid technological advances external beam radiotherapy, especially for non-coplanar dynamic techniques. Reliable comparisons doses produced by advanced radiotherapy techniques difficult limitations commercially available phantoms. There is a clear need functional phantom accurately measure dosimetric characteristics doses, which would turn allow clinicians medical...

10.1002/acm2.13514 article EN cc-by Journal of Applied Clinical Medical Physics 2022-02-01

In clinical radiotherapy, the most important aspects are dose distribution in target volume and healthy organs, including out-of-field doses body. Compared to photon beam radiation, electron radiotherapy has received much less attention, mainly due limited range of electrons tissues. However, given growing use intraoperative FLASH, further study is needed. Therefore, this study, we determined from an a phantom model using two dosimetric detectors (diode E cylindrical Farmer-type ionizing...

10.3390/life12060858 article EN cc-by Life 2022-06-08

Hypo-fractionated stereotactic body radiation therapy (SBRT) is an effective treatment for prostate cancer (PCa). Although many studies have investigated the effects of SBRT on and adjacent organs, little known about further out-of-field. The aim this study was to investigate, both in vitro a quasi-humanoid phantom, biological (using dose-scaling approach) out-of-field peripheral organs delivered by 6 MV volumetric modulated arc (VMAT) model. Healthy cells were irradiated phantom at...

10.3390/cancers14112712 article EN Cancers 2022-05-30

Survival outcomes after primary radiotherapy for localized prostate cancer (PCa) are excellent, regardless of the specific treatment modality. For this reason, health-related quality life (HRQOL) has come to play an ever more important role in selection. Stereotactic body radiation therapy (SBRT) is increasingly used treat patients with PCa. However, impact volume on HRQOL not clear. In study, we aimed determine whether a large negatively influences undergoing ultrahypofractionated SBRT.We...

10.3390/jpm13020233 article EN Journal of Personalized Medicine 2023-01-28

Abstract Human induced pluripotent stem cells (hiPSCs) can be differentiated into chondrocyte-like cells. However, implantation of these is not without risk given that those transplanted may one day undergo ionizing radiation (IR) in patients who develop cancer. We aimed to evaluate the effect IR on from hiPSCs by determining their gene and microRNA expression profile proteomic analysis. Chondrocyte-like were placed a purpose-designed phantom model laryngeal cancer irradiated with 1, 2, or 3...

10.1038/s41598-021-86230-1 article EN cc-by Scientific Reports 2021-04-05

Hypofractionated stereotactic body radiation therapy (SBRT) for prostate cancer (PCa) can be delivered with the robot-assisted CyberKnife (CK) system or on a linear accelerator using dynamic intensity-modulated radiotherapy (IMRT) volumetric arc (VMAT). This retrospective study was performed to determine whether CK offers better dose distribution than IMRT and/or VMAT.Treatment plans three techniques were prepared same treatment parameters (36.35 Gy, 7.25 Gy/fr). We evaluated target...

10.2478/raon-2022-0010 article EN cc-by-nc-nd Radiology and Oncology 2022-03-28

The aim of the study was to determine influence a key treatment plan and beam parameters on overall dose distribution doses in organs laying further distance from target during prostate SBRT. Multiple representative plans (n = 12) for TrueBeam CyberKnife were prepared evaluated. Nontarget measured with anionization chamber, quasi-humanoid phantom at four sites corresponding intestines, right lung, thyroid, head. following modified: radiotherapy technique, presence or not flattening filter,...

10.3390/life12050628 article EN cc-by Life 2022-04-23

Celem pracy jest analiza statystki dawek w narządach krytycznych dla zmian nowotworowych zlokalizowanych kościach leczonych paliatywnie planów zrealizowanych za pomocą stereotaktycznego zrobotyzowanego systemu CyberKnife. Wybrano 15 pacjentów, którym zostały wcześniej przygotowane plany leczenia dedykowanym systemie planowana leczenia. Grupę stanowili pacjenci ze zmianami nowotworowymi zlokalizowanymi kręgosłupie piersiowym oraz lędźwiowym o różnej liczbie frakcji (1, 3, 5) i dawce zadanej...

10.21641/los.2024.21.2.256 article PL Letters in Oncology Science 2024-12-10

In the treatment of prostate cancer with radiation therapy, addition a simultaneous integrated boost (SIB) to dominant intraprostatic lesions (DIL) may improve local control. this study, we aimed determine optimal strategy in phantom model using volumetric modulated arc therapy for stereotactic body radiotherapy (SBRT-VMAT) SIB 1-4 DILs.We designed and printed three-dimensional anthropomorphic pelvis simulate individual patient structures, including gland. A total 36.25 Gy (SBRT) was...

10.3389/fonc.2023.1147593 article EN cc-by Frontiers in Oncology 2023-04-28
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