A5103265449- Electrocatalysts for Energy Conversion
- RNA Interference and Gene Delivery
- Advanced Photocatalysis Techniques
- Advanced battery technologies research
- Electrochemical Analysis and Applications
- RNA and protein synthesis mechanisms
- Advanced biosensing and bioanalysis techniques
- Lipid Membrane Structure and Behavior
- CO2 Reduction Techniques and Catalysts
- Immune Response and Inflammation
- DNA and Nucleic Acid Chemistry
- Studies on Chitinases and Chitosanases
- Nitric Oxide and Endothelin Effects
- Nanomaterials for catalytic reactions
- Radiopharmaceutical Chemistry and Applications
- Cell Adhesion Molecules Research
- Medical Imaging and Pathology Studies
- Medical Imaging Techniques and Applications
- Ammonia Synthesis and Nitrogen Reduction
- Antimicrobial Peptides and Activities
- Bacterial Genetics and Biotechnology
- Glycosylation and Glycoproteins Research
- Alzheimer's disease research and treatments
- Phosphodiesterase function and regulation
- Covalent Organic Framework Applications
KTH Royal Institute of Technology
2023-2025
Sungkyunkwan University
2020-2023
Institute for Basic Science
2020-2023
Kansai University
2022
Agricultural Genetics Institute
2022
Sookmyung Women's University
2021
Vietnam Academy of Science and Technology
2017
Osaka University
2008-2011
Proportional Technologies
2008
Single-atom-catalysts (SACs) afford a fascinating activity with respect to other nanomaterials for hydrogen evolution reaction (HER), yet the simplicity of single-atom center limits its further modification and utilization. Obtaining bimetallic single-atom-dimer (SAD) structures can reform electronic structure SACs added atomic-level synergistic effect, improving HER kinetics beyond SACs. However, synthesis identification such SAD remains conceptually challenging. Herein, systematic...
The electrocatalytic nitrite reduction (NO2RR) converts nitrogen-containing pollutants to high-value ammonia (NH3) under ambient conditions. However, its multiple intermediates and multielectron coupled proton transfer process lead low activity NH3 selectivity for the existing electrocatalysts. Herein, we synthesize a solid-solution copper-zinc cyanamide (Cu0.8Zn0.2NCN) with localized structure distortion tailored surface electrostatic potential, allowing asymmetric binding of NO2-. It...
Abstract The electrocatalytic nitrate reduction (NO 3 RR) holds significance in both NH synthesis and contamination remediation. However, achieving industrial‐scale current high stability membrane electrode assembly (MEA) electrolyzer remains challenging due to inherent full‐cell voltage for sluggish NO RR water oxidation. Here, Cu 2 NCN with positive surface electrostatic potential V S (r) is applied as highly efficient electrocatalysts achieve industrial‐current low‐voltage stable...
Abstract The exact understanding for each promotional role of cation and anion vacancies in bifunctional water splitting activity will assist the development an efficient activation strategy inert catalysts. Herein, systematic first‐principles computations demonstrate that synergy anion–oxygen cation–manganese ( V O Mn ) manganese dioxide (MnO 2 nanosheets results abnormal local lattice distortion electronic modulation. Such alterations enrich accessible active centers, increase...
Amorphization of the support in single-atom catalysts is a less researched concept for promoting catalytic kinetics through modulating metal-support interaction (MSI). We modeled ruthenium (RuSAs ) supported on amorphous cobalt/nickel (oxy)hydroxide (Ru-a-CoNi) to explore favorable MSI between RuSAs and skeleton alkaline hydrogen evolution reaction (HER). Differing from usual crystal counterpart (Ru-c-CoNi), electrons are facilitated exchange among local configurations (Ru-O-Co/Ni) Ru-a-CoNi...
Abstract Hydrogen generation by electrolysis of water in an alkaline solution is a promising technology for clean hydrogen energy. Amorphous materials show much better performance than their crystalline counterparts. However, it still challenging to design amorphous metal materials. Here, series transition nanoparticles (NPs) successfully synthesized using twisted covalent organic network (CON) that can provide carbon layers as well asymmetrically distributed nitrogen. With the fixed monomer...
Reports of a high-affinity ligand for E-selectin, sialyl di-Lewis(x) (sLe(x)Le(x), 1), motivated us to incorporate modifications previously reported biphenyl-based inhibitors that would provide additional interactions with the protein. These compounds were assayed ability inhibit binding Lewis(x) (sLe(x), 2) bearing HL-60 cells E-, P-, and L-selectin fusion proteins. We report dimeric or trimeric containing multiple components simple nonoligosaccharide selectin antagonists sLe(x)-dependent...
Sitaxsentan (1) (Wu et al. J. Med. Chem. 1997, 40, 1690) is our first endothelin antagonist being evaluated in clinical trials. It has demonstrated biological effects an acute hemodynamic study CHF (Givertz Circulation 2000, 101, 2922), open-label 20-patient pulmonary hypertension trial (Barst Chest 2002, 121, 1860-1868), and a 31-patient essential (Calhoun AHA Scientific Sessions 2000). In phase 2b/3 arterial trial, once day treatment of 100 mg sitaxsentan statistically significantly...
Recently, many research studies have been focused on anion or cation substitution into the lattice of pyrite-type cobalt disulfide (CoS2) for enhancing hydrogen evolution reaction (HER) performance. Nonetheless, finding correct pair anion–cation dual with added synergistic effect boosting pH-universal HER activity remains an ongoing challenge. Additionally, a generalized descriptor and mechanism in alkaline media remain elusive. Herein, to elucidate obtain suitable pair, we investigated...
The calcium dependent E-selectin/sialyl Lewisx (sLex) interaction plays a key role in inflammation where it mediates the rolling of leukocytes prior to firm adhesion and extravasation from vasculature. A model E-selectin/sLex binding, along with previously reported structure-activity relationships sLex-related oligosaccharide, was used rational design non-oligosaccharide inhibitors this pivotal interaction. palladium-mediated biaryl-coupling (Suzuki) reaction as step prepare number...
A possible role of a model biomembrane, liposome, in gene expression was investigated by using the cell-free translation system. reporter protein, green fluorescence protein (GFP), expressed vitro with and without liposome prepared 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidyl chorine (POPC) cholesterol (Ch) (5.7 mM lipid concentration). In presence POPC/Ch intensity produced GFP found to be 1.67 times higher than that control after 18 h expression. The results SDS-PAGE analysis also show...
Abstract Amorphization of the support in single‐atom catalysts is a less researched concept for promoting catalytic kinetics through modulating metal–support interaction (MSI). We modeled ruthenium (Ru SAs ) supported on amorphous cobalt/nickel (oxy)hydroxide (Ru‐a‐CoNi) to explore favorable MSI between Ru and skeleton alkaline hydrogen evolution reaction (HER). Differing from usual crystal counterpart (Ru‐c‐CoNi), electrons are facilitated exchange among local configurations (Ru‐O‐Co/Ni)...
Developing high-performance cathode catalysts by a natural extension of renowned single-atom (SACs) for electrochemical CO2 reduction (CRR) into useful chemical feedstocks has recently received great attention, but challenges remain due to the lack rational design as well poor understanding their high selectivity and activity. Here we use density functional theory (DFT) calculations systematically investigate supremacy extended metallic biatom (BACs), namely Cu-based non-noble transition...
Sitaxsentan (3, TBC11251) (Wu et al. J. Med. Chem. 1997, 40, 1690) is an orally active ET(A) selective endothelin antagonist that attenuates pulmonary vascular hypertension and cardiac hypertrophy in rats (Tilton Pulm. Pharmacol. Ther. 2000, 13, 87). It has demonstrated efficacy a phase II clinical trial for congestive heart failure (Givertz Circulation 101, 2922). During the discovery of 3, we observed several structure-oral bioavailability relationships. To investigate whether there any...
The levels of development cognitive mental processes and personal qualities among specialists the Navy Socialist Republic Vietnam undergoing military service under a contract were considered, their relationship with military-professional success was assessed. In July 2023, from Kirov Military Medical Academy together Vietnamese Russian–Vietnamese Tropical Center, conducted pilot psychological psychophysiological examination naval to study characteristics (attention, memory, thinking),...
We have previously disclosed the discovery of 2,4-disubstituted anilinothiophenesulfonamides with potent ETA-selective endothelin receptor antagonism and subsequent identification sitaxsentan (TBC11251, 1) as a clinical development compound (Wu et al. J. Med. Chem. 1997, 40, 1682 1690). The orally active 1 has demonstrated efficacy in phase II trial congestive heart failure (Givertz Circulation 1998, 98, Abstr. #3044) was rat models myocardial infarction (Podesser #2896) acute...
It remains a great challenge to explore high-performance electrocatalysts for the CO2 reduction reaction (CO2RR) with high activity and selectivity. Herein, we employ first principles calculations systematically investigate an emerging family of extended surface catalysts, bi-atom catalysts (BACs), in which bimetals anchored on graphitic carbon nitride (g-CN), CO2RR; propose novel framework boost CO2RR via incorporation well-defined clusters. Among 28 BACs, five candidates (Cr2, CrFe, Mn2,...