A5051421694- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Sepsis Diagnosis and Treatment
- Trauma and Emergency Care Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Blood transfusion and management
- Acute Kidney Injury Research
- Renal function and acid-base balance
- Blood Coagulation and Thrombosis Mechanisms
University of Amsterdam
2023-2025
Amsterdam University Medical Centers
2019-2025
Amsterdam UMC Location University of Amsterdam
2020
Background The dysregulated immune response during sepsis involves endothelial injury, which may be augmented by infusion of clear fluids such as crystalloids. Plasma has been suggested an alternative resuscitation fluid but it is unclear whether previously observed benefits were due to the type fluid, or less volume required restore tissue perfusion. We hypothesized that with plasma reduces inflammation, and organ injury compared similar higher volumes crystalloids in a rat pneumosepsis...
Platelet dysfunction importantly contributes to trauma-induced coagulopathy (TIC). Our aim was examine the impact of transfusing platelets (PLTs) in a 2:1 PLT-to-red blood cell (RBC) ratio versus standard 1:1 on transfusion requirements, correction TIC, and organ damage rat multiple trauma model. Mechanically ventilated male Sprague Dawley rats were traumatized by crush injury small intestine liver fracture femur, followed exsanguination until mean arterial pressure (MAP) 40 mmHg. Animals...
Endothelial injury and permeability are a hallmark of sepsis. Initial resuscitation septic patients with crystalloids is associated aggravation endothelial permeability, which may be related either to low protein content or volume. We investigated whether initial different types plasma albumin decreases dysfunction organ in pneumosepsis rat model compared the same volume crystalloids. Sprague-Dawley rats were intratracheally inoculated Streptococcus pneumoniae. Twenty-four hours after...
Abstract Introduction In hemorrhaging trauma patients, the endothelium is activated, resulting in excessive endothelial synthesis of von Willebrand Factor (vWF), which may enhance micro-thrombi formation, obstruction microcirculation and injury, aggravating bleeding, as well contributing to organ failure. Under normal conditions, vWF cleaved by metalloprotease ADAMTS-13. After trauma, ADAMTS-13 levels are reduced. Objectives To assess whether recombinant human inhibits injury failure a rat...
Septic shock is characterized by endothelial dysfunction, leading to tissue edema and organ failure. Heparan sulfate (HS) essential for vascular barrier integrity, possibly via albumin as a carrier. We hypothesized that supplementing fluid resuscitation with HS would improve function, thereby reducing injury in rat pneumosepsis model. Following intratracheal inoculation Streptococcus pneumoniae, Sprague Dawley rats were randomized fixed volume of either Ringer’s Lactate (RL, standard care),...