A5035153549- Autism Spectrum Disorder Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Advanced Neuroimaging Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Alzheimer's disease research and treatments
- Fetal and Pediatric Neurological Disorders
- Genomic variations and chromosomal abnormalities
Athinoula A. Martinos Center for Biomedical Imaging
2020-2025
Harvard University
2025
Massachusetts General Hospital
2020-2025
Center for Autism and Related Disorders
2025
Abstract Autism spectrum disorder is a neurodevelopmental condition characterized by reduced social communication and repetitive behaviors. Altered neurogenesis, including disturbed neuronal migration, has been implicated in autism disorder. Using diffusion MRI, we previously identified migration pathways the human fetal brain hypothesized that similar persist into adulthood, with differences volume microstructural characteristics between individuals controls. We analyzed MRI–based...
Abstract Sex-based differences in the prevalence of autism spectrum disorder (ASD) are well-documented, with a male-to-female ratio approximately 4:1. The clinical presentation core symptoms ASD can also vary between sexes. Previously, positron emission tomography (PET) studies have identified alterations vivo levels translocator protein (TSPO)—a mitochondrial protein—in primarily or only male adults ASD, our group reporting lower TSPO relative to whole brain mean males ASD. However, whether...
The human 18 kDa translocator protein (TSPO) has been widely used as a measure of glial activation in health and disease. With the continuous progress radiotracers with increased affinity selectivity, associations between TSPO expression, disease severity, progression have examined, particularly neurodegenerative disorders such multiple sclerosis (MS), Parkinson's (PD), amyotrophic lateral (ALS). However, findings psychiatric prompted reassessment interpretation regional expression...