A5101703918- Nanopore and Nanochannel Transport Studies
- Advanced biosensing and bioanalysis techniques
- Molecular Junctions and Nanostructures
- Force Microscopy Techniques and Applications
- Electronic and Structural Properties of Oxides
- Microfluidic and Capillary Electrophoresis Applications
- DNA and Nucleic Acid Chemistry
- Physics of Superconductivity and Magnetism
- Nanowire Synthesis and Applications
- Surface Chemistry and Catalysis
- Microfluidic and Bio-sensing Technologies
- ZnO doping and properties
- Fuel Cells and Related Materials
- Surface and Thin Film Phenomena
- Biosensors and Analytical Detection
- Mechanical and Optical Resonators
- Electrostatics and Colloid Interactions
- Magnetic and transport properties of perovskites and related materials
- Ion-surface interactions and analysis
- Membrane-based Ion Separation Techniques
- Electrochemical Analysis and Applications
- Analytical Chemistry and Sensors
- Lipid Membrane Structure and Behavior
- Advanced Memory and Neural Computing
- Nanofabrication and Lithography Techniques
Osaka University
2016-2025
Osaka Research Institute of Industrial Science and Technology
2014-2024
National Institute of Advanced Industrial Science and Technology
2022
Huazhong University of Science and Technology
2022
Konkuk University
2009-2014
Konkuk University Medical Center
2011-2013
Japan Science and Technology Agency
2004-2010
Osaka Prefecture University
2009
The University of Tokyo
2008
Hokkaido University of Science
2008
We report direct measurements of electrical transport through poly(dA)-poly(dT) and poly(dG)-poly(dC) DNA molecules containing identical base pairs. The observed experimental results suggest that occurs by polaron hopping. have also investigated the effect gate voltage on current-voltage curve. It demonstrates possibility a field-effect transistor operating at room temperature. Moreover, gate-voltage dependent show behaves as an $n$-type semiconductor, whereas $p$-type semiconductor.
We demonstrate the first reported methodology using nanowires that unveils massive numbers of cancer-related urinary microRNAs.
We report direct measurements of the intrinsic electrical characteristics polynucleotides using a conducting-probe atomic-force microscope under vacuum. Poly(dA)⋅poly(dT) self-assemble cross-interlaced network on mica, but poly(dG)⋅poly(dC) self-organize uniform two-dimensional reticulated structure. Transport studies demonstrate that can act as semiconducting nanowire and show better conductance than in poly(dA)⋅poly(dT).
One major challenge of nanopore-based DNA sequencing technology is to find an efficient way reduce translocation speed so that each nucleotide can reside long enough in the pore for interrogation. Here we report electrical tuning by gate modulation nanopore wall surface charges. We native surface-charge-induced counterions electroosmotic layer substantially enhance advection flow fluid, which exerts stronger dragging forces on translocating DNA, and thereby lowering speed. propose a feedback...
Two paradigm shifts in DNA sequencing technologies—from bulk to single molecules and from optical electrical detection—are expected realize label-free, low-cost that does not require PCR amplification. It will lead development of high-throughput third-generation technologies for personalized medicine. Although nanopore devices have been proposed as DNA-sequencing devices, a significant milestone these has attained by demonstrating novel technique resequencing using signals. Here we report...
Immunosensing is a bioanalytical technique capable of selective detections pathogens by utilizing highly specific and strong intermolecular interactions between recognition probes antigens. Here, we exploited the molecular mechanism in artificial nanopores for single-virus identifications. We designed hemagglutinin antibody mimicking oligopeptides with weak affinity to influenza A virus. By functionalizing pore wall surface synthetic peptides, rendered specificity virion–nanopore...
Abstract Artificial nanofluidic networks are emerging systems for blue energy conversion that leverages surface charge‐derived permselectivity to induce voltage from diffusive ion transport under salinity difference. Here the pivotal significance of electrostatic inter‐channel couplings in multi‐nanopore membranes, which impose constraints on porosity and subsequently influence generation large osmotic power outputs, is illustrated. Constructive interference observed between two 20 nm...
Nanofluidic channels in a membrane represent promising avenue for harnessing blue energy from salinity gradients, relying on permselectivity as pivotal characteristic crucial inducing electricity through diffusive ion transport. Surface charge emerges central player the osmotic conversion process, emphasizing critical significance of judicious selection materials to achieve optimal permeability and selectivity within specific channel dimensions. Alternatively, here we report field-effect...
Thin films of (Ca,Sr)CuO2, the parent material high Tc cuprate superconductors, have been formed by laser ablation method under molecular beam epitaxial condition, and growth mechanism has investigated with reflection high-energy electron diffraction (RHEED). Analyses RHEED patterns intensity oscillations show that this grows two-dimensional layer growth. When all metal elements are supplied simultaneously in NO2 atmosphere, occurs unit-cell (Ca,Sr)CuO2. Furthermore, it become evident unit...
Crystallized as-grown Bi(Pb)-Sr-Ca-Cu-O thin films are formed by the laser ablation method at a substrate temperature as low 480 °C under N2O gas flow. Moreover, film, which has crystal structure consisting of four or five CuO2 layers between adjacent Bi2O2 layers, can be combination flow and successive deposition with excimer pulses.
The self-breaking mechanism of gold junctions is studied by investigating stability the atom-sized contacts. single atom contact lifetime increases from about 0.02 to 200 s upon decreasing junction stretching speed, while at same time, breaking force diminishes logarithmically. We find that processes involve sufficient atomic rearrangements, which thereby allow complete self-compensation externally introduced strain 0.8 pm/s. present results have important implications on fabrication stable...
Resistive switching (RS) memory effect in metal-oxide-metal junctions is a fascinating phenomenon toward next-generation universal nonvolatile memories. However the lack of understanding electrical nature RS has held back applications. Here we demonstrate bipolar cobalt oxides, such as conduction mechanism and location, by utilizing planar single oxide nanowire device. Experiments field devices multiprobe measurements have shown that nanoscale oxides originates from redox events near cathode...
Understanding biophysics governing DNA capture into a nanopore and establishing manipulation system for the process are essential nanopore-based genome sequencing. In this work, functionality of extended electric field electroosmotic flow (EOF) during stage their dependence on gate voltage, UG, investigated. We demonstrate that while both EOF within cis chamber make long-distance contributions to around pore mouth, former effect is always capturing, latter causes trapping or blocking...
We report a technique that can be utilized as nanoscale thermometer and its application to metal-molecule-metal junctions at room temperatures. find molecular junction heats up 463 K 1 V. also revealed an onset bias of approximately 0.04 V for heat generation via electron-phonon scattering by examining inelastic electron tunneling spectroscopy. The present results suggest the importance attaining optimal thermal link molecule-electrode interfaces providing practically sufficient electrical...
Electrically driven resistance change in metal oxides opens up an interdisciplinary research field for next-generation non-volatile memory. Resistive switching exhibits electrical polarity dependent "bipolar-switching" and a independent "unipolar-switching", however tailoring the has been challenging issue. Here we demonstrate scaling effect on emergence of by examining resistive behaviors Pt/oxide/Pt junctions over 8 orders magnitudes areas. We show that two polarities can be categorised as...
The symmetry of a molecule junction has been shown to play significant role in determining the conductance molecule, but details how changes with have heretofore unknown. Herein, we investigate naphthalenedithiol single-molecule system which sulfur atoms from are anchored two facing gold electrodes. In studied system, highest conductance, for 1,4-symmetry, is 110 times larger than lowest 2,7-symmetry. We demonstrate clearly that measured dependence junctions agrees theoretical predictions.
We explored single-particle translocation through a low thickness-to-diameter aspect ratio Si(3)N(4) pore mimicking graphene nanopore structure by resistive pulse method. Ionic conductance of 0.05 pores scales linearly with the diameter, indicating predominant contribution access resistance to ion transport. find that changes little during particle translocation. Furthermore, we observe enhanced capture rates via strong electric field extended outside low-aspect-ratio mouth. also demonstrate...
Electrode-embedded nanopore is considered as a promising device structure for label-free single-molecule sequencing, the principle of which based on nucleotide identification via transverse electron tunnelling current flowing through DNA translocating pore. Yet, fabrication molecular-scale electrode-nanopore detector has been formidable task that requires atomic-level alignment few nanometer sized pore and an electrode gap. Here, we report detection using nucleotide-sized sensing embedded...
Manipulating DNA translocation through nanopore is one crucial requirement for new ultrafast sequencing methods in the sense that polymers have to be denatured, unraveled, and then propelled pore with very low speed. Here we propose theoretically explore a novel design fulfill demands by utilizing cross-pore thermal gradient. The high temperature cis reservoir expected transform double-stranded into single strands would also prevent those from intrastrand base-pairing, thus, achieving...
Abstract Rapid diagnosis of flu before symptom onsets can revolutionize our health through diminishing a risk for serious complication as well preventing infectious disease outbreak. Sensor sensitivity and selectivity are key to accomplish this goal the number virus is quite small at early stage infection. Here we report on label-free electrical diagnostics influenza based nanopore analytics that distinguishes individual virions by their distinct physical features. We selective...
Resistive pulse sensing with nanopores having a low thickness-to-diameter aspect-ratio structure is expected to enable high-spatial-resolution analysis of nanoscale objects in liquid. Here we investigated the capability low-aspect-ratio pore sensors by monitoring ionic current blockades during translocation polymeric nanobeads. We detected numerous small spikes due partial occlusion orifice particles diffusing therein reflecting expansive electrical zone pores. also found wide variations ion...