A5079676491- Pain Mechanisms and Treatments
- Retinal Development and Disorders
- Neurogenesis and neuroplasticity mechanisms
- Photoreceptor and optogenetics research
- Developmental Biology and Gene Regulation
- Wnt/β-catenin signaling in development and cancer
- RNA Research and Splicing
- Retinal Diseases and Treatments
- Pharmacological Effects of Natural Compounds
- Cellular Mechanics and Interactions
- Urological Disorders and Treatments
- Axon Guidance and Neuronal Signaling
- Myofascial pain diagnosis and treatment
- Veterinary Pharmacology and Anesthesia
- Botulinum Toxin and Related Neurological Disorders
- Animal Genetics and Reproduction
- Gastrointestinal motility and disorders
- Neuroscience and Neuropharmacology Research
- Cancer-related gene regulation
- Livestock and Poultry Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Acupuncture Treatment Research Studies
- Musculoskeletal pain and rehabilitation
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
Universidad Internacional De La Rioja
2020-2024
Universidad Autónoma de Madrid
2011-2020
Centro de Biología Molecular Severo Ochoa
2011-2020
Centre for Biomedical Network Research on Rare Diseases
2008-2019
Universidad de Alcalá
2015-2019
Instituto de Neurociencias de Castilla y León
2019
Centro de Investigación Biomédica en Red
2019
Instituto de Estudios de Ciencias de la Salud de Castilla y León
2019
Instituto de Investigación Biomédica de Salamanca
2019
Universidad de Salamanca
2019
Timely generation of distinct neural cell types in appropriate numbers is fundamental for the a functional retina. In vertebrates, transcription factor Six6 initially expressed multipotent retina progenitors and then becomes restricted to differentiated retinal ganglion amacrine cells. How expression controlled what are its precise functions still unclear. To address this issue, we used bioinformatic searches transgenic approaches medaka fish (Oryzias latipes) characterise highly conserved...
The vertebrate forebrain is patterned during gastrulation into telencephalic, retinal, hypothalamic and diencephalic primordia. Specification of each these domains requires the concerted activity combinations transcription factors (TFs). Paradoxically, some are widely expressed in forebrain, which raises question how they can mediate regional differences. To address this issue, we focused on homeobox TF Six3.2. With genomic functional approaches demonstrate that, medaka fish, Six3.2...
In the vertebrate neuroepithelium, decision to differentiate is made by neural precursors soon after mitosis, when they are apically located. This process controlled lateral inhibitory signals triggered Delta/Notch pathway. During capacity of express neurogenic genes Dll1 and Notch1 maximal due mRNA stabilization, but mechanism controlling this remains unknown. Here we show that Elav-like (Elavl1)/HuR becomes enriched in cytoplasm neuroepithelial cells undergoing mitosis ribonucleoprotein...
Kv7.2 channel expression has been reported to decrease in dorsal root ganglia (DRG) following the induction of a peripheral neuropathy while other experiments show that accumulates neuromas. The mechanisms underlying these novel patterns are poorly understood. Here we use immunofluorescence methods analyze protein changes sensory neurons axotomy and potential role axonal transport. Results indicate DRG express ~16% this number decreases by about 65% after axotomy. Damaged were identified...
In the context of neuropathic pain, contribution regeneration to development positive symptoms is not completely understood. Several efforts have been done described changes in axotomized neurons, however, there scarce data on occurring intact despite experimental evidence functional changes. To address this issue, we analysed by immunohistochemistry presence phosphorylated signal transducer and activator transcription 3 (pSTAT3), an accepted marker regeneration, within DRGs where neurons...
Millions of individuals worldwide suffer from impaired vision, a condition with multiple origins that often impinge upon the light sensing cells retina, photoreceptors, affecting their integrity. The molecular components contributing to this integrity are however not yet fully understood. Here we have asked whether Secreted Frizzled Related Protein 1 (SFRP1) may be one such factors. SFRP1 has context-dependent function as modulator Wnt signalling or proteolytic activity A Disintegrin And...
Abstract Immunohistochemical characterization of primary afferent fibers (intact or after nerve damage) is traditionally performed in thin sections from dorsal root ganglia (DRGs) teased fibers, as light scattering whole-mounts compromises visualization. These procedures are time-consuming, require specific equipment and advanced experimental skills. Lipid-clearing techniques increasing popularity, but they have never been used for the peripheral nervous system. We established a modified,...
Abstract Millions of individuals worldwide suffer from impaired vision, a condition with multiple origins that often impinge upon the light sensing cells retina, photoreceptors, affecting their integrity. The molecular components contributing to this integrity are however not yet fully understood. Here we have asked whether Secreted Frizzled Related Protein 1 (SFRP1) may be one such factors. SFRP1 has context-dependent function as modulator Wnt signalling or proteolytic activity A...