A5059459423- Neurological disorders and treatments
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Neurological and metabolic disorders
- Photoreceptor and optogenetics research
- Neuroinflammation and Neurodegeneration Mechanisms
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- EEG and Brain-Computer Interfaces
Hebrew University of Jerusalem
2016-2022
Weizmann Institute of Science
2020-2021
Emory University
2016
The striatum and the subthalamic nucleus (STN) constitute input stage of basal ganglia (BG) network together innervate BG downstream structures using GABA glutamate, respectively. Comparison neuronal activity in reveals that subthalamic, not striatal, fluctuations correlate with modulations increase/decrease discharge balance neurons during temporal discounting classical condition task. After induction parkinsonism 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), abnormal low beta (8-15...
ABSTRACT Background: The efficacy of deep brain stimulation (DBS) ‐ primarily the subthalamic nucleus (STN) for advanced Parkinson's disease (PD) is commonly attributed to suppression pathological synchronous β oscillations along cortico‐thalamo‐basal ganglia network. Conventional continuous high‐frequency DBS indiscriminately influences and normal neural activity. protocol would therefore be more effective if was only applied when necessary (closed‐loop adaptive DBS). Objectives Methods:...
Βeta oscillatory activity (human: 13-35 Hz; primate: 8-24 Hz) is pervasive within the cortex and basal ganglia. Studies in Parkinson's disease patients animal models suggest that beta-power increases with dopamine depletion. However, exact relationship between power, frequency tone remains unclear. We recorded neural ganglia of healthy non-human primates while acutely chronically up- down-modulating levels. assessed changes beta oscillations following acute chronic tone. Here we show...
Abstract Beta oscillatory activity (13-30Hz) is pervasive within the cortico-basal ganglia (CBG) network. Studies in Parkinson’s disease (PD) patients and animal models suggested that beta-power increases with dopamine depletion. However, exact relationship between power, frequency dopamine-tone remains unclear. We recorded neural CBG network of non-human-primates (NHP) while acutely up- down-modulating levels. Further, we assessed changes beta oscillations PD following acute chronic...
Abstract Spontaneous pauses in firing are the hallmark of external pallidum (GPe) neurons. However, role GPe basal ganglia network remains unknown. Pupil size and saccadic eye movements have been linked to attention exploration. Here, we recorded spiking activity corresponding pupil sizes positions non-human primates. We show that pauses, rather than discharge rate per se, were associated with dilated pupils. In addition, following pause initiation there was a considerable increase...
Abstract Spontaneous pauses in firing are the hallmark of external pallidum (GPe) neurons. However, their role basal ganglia (BG) network remains unknown. Pupil size and saccades have been linked to attention exploration. Here, we show that associated with dilated pupils increased saccade rate. Our results suggest a powerful mechanism by which GPe may influence BG downstream structures affect behavioral output.