A5037926341- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- RNA Interference and Gene Delivery
- Acute Myeloid Leukemia Research
- Bee Products Chemical Analysis
- PI3K/AKT/mTOR signaling in cancer
- Nanoparticle-Based Drug Delivery
- Essential Oils and Antimicrobial Activity
- Histone Deacetylase Inhibitors Research
- Acute Lymphoblastic Leukemia research
- Advanced biosensing and bioanalysis techniques
- Eosinophilic Esophagitis
- MicroRNA in disease regulation
- Gastroesophageal reflux and treatments
- Cytokine Signaling Pathways and Interactions
- Healthcare and Venom Research
- Nuts composition and effects
- Cancer, Lipids, and Metabolism
- Helicobacter pylori-related gastroenterology studies
- Immune Response and Inflammation
- Synthesis and biological activity
- Legionella and Acanthamoeba research
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Retinoids in leukemia and cellular processes
Ege University
2016-2025
Ege Üniversitesi Tıp Fakültesi Hastanesi
2018-2025
Saints Cyril and Methodius University of Skopje
2019
Dokuz Eylül University
2019
Selçuk Üniversitesi Tıp Fakültesi Hastanesi
2015
Recently, it has been shown that protein phosphatase 2A (PP2A) dysfunction was common in many cancer types and mediated by various inactivation mechanisms. Although research studies observed antitumor effect of propolis extracts cancer, the mechanism are still obscure. In this study, we investigated on PPP2R1A expression its relationship with apoptosis SW‐620 (colorectal cancer), DU‐145 PC‐3 (prostate MCF‐7 (breast cancer) cell lines, WI‐38 (healthy fibroblast) cells serving as control....
In recent years, natural products gained popularity with their anti-inflammatory and antioxidant effects mediated by chemical compounds within composition. Study results offering them as palliative therapy options in cancer or anticancer agents high levels of cytotoxicity brought a new approach to combine treatment protocols these products. From different perspective, edible types are suggested daily diets due potential preventive effects. Our preliminary work was on blueberry extracts...
Propolis has a lots of properties related to human health: antioxidant, antimicrobial, antiseptic, antibacterial, anti-inflammatory, antimutagenic, and immunomodulating. Its possible effects on different cancers are among the priorities these properties. So, in this study, comparative cytotoxic biotransformed propolis samples colon cancer cells healthy epithelium were investigated. Before starting extraction procedure, done by using solvents (ethanol; poly-ethylene glycol - PEG; water )...
Background/AimsGastroesophageal reflux disease is frequently observed and has no definitive treatment.There are 2 main views on the pathogenesis of gastroesophageal disease.The first that epithelial damage starts from mucosa by acidic-peptic inflammatory response granulocytes.The other view T-lymphocytes attract chemoattractants basal layer to mucosa, granulocytes do not migrate until occurs.We aim investigate processes occurring in esophageal epithelium phenotypes at molecular level.We also...
BCR-ABL oncoprotein stimulates cell proliferation and inhibits apoptosis in chronic myeloid leukemia (CML). For cure, imatinib is a widely used tyrosine kinase inhibitor, but developing chemotherapeutic resistance has to be overcome. In this study, we aimed determine differing genome-wide microRNA (miRNA) messenger RNA (mRNA) expression profiles resistant (K562/IMA-3 μM) parental cells by targeting STAT5A via small interfering (siRNA) applications. After determining possible therapeutic...
Currently, the primary treatment for gastroesophageal reflux is acid suppression with proton pump inhibitors, but they are not a cure, and some patients don't respond well or refuse long-term use. Therefore, alternative therapies needed to understand disease develop better treatments. Laparoscopic anti-reflux surgery (LARS) can resolve symptoms of these plays significant role in evaluating esophageal healing after preventing harmful effects. Successful LARS improves typical most patients,...
Previously, we demonstrated that biotransformation of propolis by some special strains Lactobacillus plantarum might decrease the allergenic molecules in propolis. In this study, aimed to investigate effect on its antioxidant and protective against potassium bromate‐induced cancer human colon cell line. Propolis samples were treated with different solutions (ethanol, polyethylene glycol, water), ultrasonication was applied at 40 Hz (5, 10, 15 minutes) order facilitate solvation solid...
Myeloid or granulocytic sarcoma (GS) is a tumoral lesion consisting of immature cells. It rare entity during the course CML patients especially after allogeneic stem cell transplantation (SCT). Relapse without bone marrow involvement much rarer. We report case patient who relapsed with isolated SCT cytogenetic and molecular remission. 28-year-old male was diagnosed as performed because refractory disease to tyrosine kinase inhibitors. Complete response achieved followed by dasatinib...
Aim: Chronic myeloid leukemia (CML) displays a constitutive tyrosine kinase (TK) activity which in turn leads to the activation of various signaling pathways and outcome leukemic phenotype. Activated STAT5A STAT5B from JAK/STAT pathway induce cell growth, proliferation, differentiation, survival cells are promoted by cytokine network. Since second-generation inhibitor nilotinib has advantage inhibiting this oncogenic TK activity; we aimed investigate underlying mechanism its therapeutic...
Abstract Thyroid cancer is the most common malignant tumor of endocrine system seen in thyroid gland. More than 90% cancers comprise papillary (PTC) and follicular (FTC). Although anaplastic carcinoma (ATC) accounts for less 2% cancer. But patients' lifespan after diagnosis about 6 months. Surgical interventions, radioactive iodine use, chemotherapy are not sufficient treatment ATC, so alternative therapies needed. The WST-1 assay test was performed to evaluate anti-proliferative effects...
Abstract Objectives Rituximab is a monoclonal antibody that targets the B-lymphocyte surface antigen CD20. It used in treatment of some diseases including B-cell chronic lymphocytic leukemia (B-CLL). There are lot data regarding effect on lymphoma cells. But, there no satisfactory information about signaling pathways In this study, it was aimed to understand JAK-STAT and NF-κB acute lymphoblastic (B-ALL) B-CLL. Material methods Apoptotic TANOUE EHEB (B-CLL) cell lines were evaluated by using...