A5077706124- Growth Hormone and Insulin-like Growth Factors
- Thyroid Disorders and Treatments
- Reproductive Physiology in Livestock
- Virus-based gene therapy research
- Digestive system and related health
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Infant Nutrition and Health
Purdue University West Lafayette
2021-2024
Porcine reproductive and respiratory syndrome virus (PRRSV) in late gestation causes a profound suppression of circulating maternal fetal thyroid hormone during critical window development. To understand this relationship, we evaluated metabolism at the maternal-fetal interface within tissues, along with metabolite levels serum. Fetuses were classified using an established model based on viral load serum thymus, preservation status, including uninfected (UNIF), high-viral viable (HV-VIA),...
Abstract To understand the effect of fetal thyroid gland disruption on development in swine, we evaluated hormone levels, growth and developmental characteristics, gene expression associated with metabolism late gestation fetuses exposed to methimazole (MMI). Pregnant gilts were given either oral MMI or equivalent sham from day 85–106 (n = 4/group), followed by intensive phenotyping all 120). Samples liver (LVR), kidney (KID), placenta (PLC), corresponding maternal endometrium (END)...
Abstract Thyroid hormones regulate metabolic rate, nutrient utilization, growth, and development. Swine are susceptible to thyroid suppression in response disease or environmental conditions, but the physiological impact of such disruption has not been established. The objective this study was evaluate hypothyroidism induced with antithyroid medication methimazole (MMI). 10 mg/kg MMI significantly decreased circulating triiodothyronine (T3) for duration treatment had only a transient effect...
Perinatal nutrition affects future milk production. The number of mammary epithelial cells affect production capacity. Therefore, it was hypothesized that the level colostrum intake proliferation rate and total in gland. ratio newly synthesized protein to DNA reflects relative amount cellular differentiation cell division. study objective determine relationship between 24 h-level circulating amino acid, glucose insulin with parenchyma histological features, division synthesis over first week...