A5100780962- Pulmonary Hypertension Research and Treatments
- COVID-19 Clinical Research Studies
- Cardiovascular Function and Risk Factors
- Muscle Physiology and Disorders
- Mesenchymal stem cell research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Long-Term Effects of COVID-19
- Biomarkers in Disease Mechanisms
- Cancer, Hypoxia, and Metabolism
- Nosocomial Infections in ICU
- Myasthenia Gravis and Thymoma
- Bacterial Identification and Susceptibility Testing
- Liver Disease Diagnosis and Treatment
- Cerebral Palsy and Movement Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Renin-Angiotensin System Studies
- Cardiac electrophysiology and arrhythmias
- Telomeres, Telomerase, and Senescence
- SARS-CoV-2 and COVID-19 Research
- Cardiovascular Issues in Pregnancy
- COVID-19 and healthcare impacts
- Thermal Regulation in Medicine
- Analytical Methods in Pharmaceuticals
- Venous Thromboembolism Diagnosis and Management
- Knee injuries and reconstruction techniques
Institute of Genetics and Biophysics
2023-2024
Spanish National Cancer Research Centre
2023
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2019-2022
Universitat de Barcelona
2019-2022
Institut d'Investigació Biomèdica de Girona
2020-2021
Hospital Santa Caterina
2020
Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) and arterial (PAH) are two forms of (PH) characterized by obstructive vasculopathy. Endothelial dysfunction along with metabolic changes towards increased glycolysis important in PAH pathophysiology. Less is known about such abnormalities endothelial cells (ECs) from CTEPH patients. This study provides a systematic comparison ECs derived Metabolic gene expression was studied using qPCR cultured CTEPH-EC PAH-EC. Western blot...
Abstract Pulmonary endarterectomy (PEA) resected material offers a unique opportunity to develop an in vitro endothelial cell model of chronic thromboembolic pulmonary hypertension (CTEPH). We aimed comprehensively analyze the function, molecular signature, and mitochondrial profile CTEPH-derived cells better understand pathophysiological mechanisms dysfunction behind CTEPH, identify potential novel targets for prevention treatment disease. Isolated from specimens obtained at PEA (CTEPH-EC),...
Chronic thromboembolic pulmonary hypertension (CTEPH) is a form of characterized by the presence fibrotic intraluminal thrombi and causing obliteration arteries. Although both endothelial cell (EC) dysfunction inflammation are linked to CTEPH pathogenesis, regulation basal inflammatory response ECs in not fully understood. Therefore, present study, we investigated role nuclear factor (NF)-κB pro-inflammatory signaling pathway under conditions. Basal mRNA levels interleukin (IL)-8, IL-1β,...
Skeletal muscle repair relies on heterogeneous populations of satellite cells (SCs). The mechanisms that regulate SC homeostasis and state transition during activation are currently unknown. Here, we investigated the emerging role non-genetic micro-heterogeneity, i.e., intrinsic cell-to-cell variability a population, in this process. We demonstrate micro-heterogeneity membrane protein CRIPTO mouse-activated SCs (ASCs) identifies metastable cell states allow rapid response population to...
Background Managing the inflammatory response to SARS-Cov-2 could prevent respiratory insufficiency. Cytokine profiles identify cases at risk of severe disease. Methods We designed a randomized phase II clinical trial determine whether combination ruxolitinib (5 mg twice day for 7 days followed by 10 BID days) plus simvastatin (40 once 14 days), reduce incidence insufficiency in COVID-19. 48 cytokines were correlated with outcome. Participants Patients admitted due COVID-19 infection mild...
Skeletal muscle regeneration relies on the intricate interplay of various cell populations within niche—an environment crucial for regulating behavior stem cells (MuSCs) and ensuring postnatal tissue maintenance regeneration. This review delves into dynamic interactions among key players this process, including MuSCs, macrophages (MPs), fibro-adipogenic progenitors (FAPs), endothelial (ECs), pericytes (PCs), each assuming pivotal roles in orchestrating homeostasis Dysfunctions these can lead...
Abstract Rationale: Pulmonary endarterectomy (PEA) resected material offers a unique opportunity to develop an in vitro endothelial cell model of chronic thromboembolic pulmonary hypertension (CTEPH). We aimed comprehensively analyze the function, molecular signature and mitochondrial profile CTEPH-derived cells better understand pathophysiological mechanisms dysfunction behind CTEPH, identify potential novel targets for prevention treatment disease. Methods: Isolated from specimens obtained...
<b>Background:</b> Chronic thromboembolic pulmonary hypertension (CTEPH) is caused by non-resolution of thrombi that obstruct main arteries and secondary cause vascular remodeling the vasculature. Endothelial cells (EC) lining wall are an important component in disease development. We speculated metabolic dysregulation EC contribute to cellular changes promote CTEPH. <b>Methods:</b> This study used endothelial (EC-CTEPH, n=12) isolated from specimen extracted at endarterectomy. Expression...
Hard ticks have become the main vectors of infectious diseases in industrialized world, being able to transmit bacteria, viruses and protozoa through their bite, as well causing allergic toxic processes. Among tick-borne disease most frequent our setting are boutonneuse fever, Lyme Debonel/Tibola disease. Boutonneuse fever is common rickettsiosis Europe. An increase cases has been observed recent years, probably related global temperature.
<b>Background:</b> Chronic thromboembolic pulmonary hypertension (CTEPH) and arterial (PAH) are two subtypes of (PH). Endothelial dysfunction is believed the main cause hyperproliferative antiapoptotic phenotype in PH characterized by increased glycolysis PAH. It unknown whether PAH CTEPH share same metabolic abnormalities. The aim our study to perform a systematic comparison endothelial cells (ECs) derived from patients. <b>Methods:</b> ECs human artery HPAECs (n=3), (n=7) (n=6) were...