A5000594980- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Neurological Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Medical Imaging Techniques and Applications
- Avian ecology and behavior
- Functional Brain Connectivity Studies
- Marine animal studies overview
- Neurological Disorders and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Health disparities and outcomes
- S100 Proteins and Annexins
- Advanced Neuroimaging Techniques and Applications
- Pharmaceutical Practices and Patient Outcomes
- Epilepsy research and treatment
- Health Systems, Economic Evaluations, Quality of Life
- Diet and metabolism studies
- Alkaloids: synthesis and pharmacology
- Health and Well-being Studies
- Geriatric Care and Nursing Homes
- Bat Biology and Ecology Studies
- Isotope Analysis in Ecology
- Ginkgo biloba and Cashew Applications
- Frailty in Older Adults
Tohoku University
2016-2025
Tohoku University Hospital
2021-2024
Tsukuba International University
2024
University of Tsukuba
2024
Yamashina Institute for Ornithology
2011-2022
Institute of Aging
2011-2022
Tokyo Institute of Technology
2018
Juntendo University Hospital
2018
Meijo University
2009-2015
Nagoya University
1995-2014
Imaging of neurofibrillary pathology in the brain helps diagnosing dementia, tracking disease progression, and evaluating therapeutic efficacy antidementia drugs. The radiotracers used this imaging must be highly sensitive specific for tau protein fibrils human brain. We developed a novel PET tracer, <sup>18</sup>F-THK5351, through compound optimization arylquinoline derivatives. <b>Methods:</b> vitro binding properties, pharmacokinetics, safety <sup>18</sup>F-THK5351 were investigated,...
Abstract Background Maximizing the efficiency to screen amyloid-positive individuals in asymptomatic and non-demented aged population using blood-based biomarkers is essential for future success of clinical trials early stage Alzheimer’s disease (AD). In this study, we elucidate utility combination plasma amyloid-β (Aβ)-related tau phosphorylated at threonine 217 (p-tau217) predict abnormal Aβ-positron emission tomography (PET) preclinical prodromal AD. Methods We designed cross-sectional...
Article Abstract Objective: This randomized, observer-blind, controlled trial examined the efficacy and safety of traditional Chinese herbal medicine Yi-Gan San (YGS, Yokukan-San in Japanese) improvement behavioral psychological symptoms dementia (BPSD) activities daily living (ADL). Method: Fifty-two patients with mild-to-severe (24 men 28 women, mean ± SD age = 80.3 9.0 years) according to DSM-IV criteria were investigated. Participants randomly assigned YGS group (N 27) or control...
There is evidence that certain components of the renin-angiotensin system (RAS) may have a crucial role in learning and memory processes.1,2⇓ Angiotensin-converting enzyme (ACE) overexpressed hippocampus, frontal cortex, caudate nucleus patients with Alzheimer disease (AD).1 In an animal model AD, brain-distributing ACE inhibitors are reported to rescue neuronal damage improve behavior.2 Furthermore, we shown brain-penetrating can reduce incidence AD elderly hypertensive patients.3 present...
To investigate the efficacy and safety of nitroglycerin plus vinorelbine cisplatin in patients with previously untreated stage IIIB/IV non-small-cell lung cancer (NSCLC) as experimental arm for next phase III trial.One hundred twenty NSCLC were randomly assigned to 25 mg/m2 on days 1 8 80 day 1, transdermally applied (25 mg/patient daily 5 days; A) or placebo patch (arm B) every 3 weeks a maximum four cycles double-blind controlled trial. Primary end points best confirmed response rate time...
Clinical PET studies using <sup>18</sup>F-THK5351 have demonstrated significant tracer retention in sites susceptible to tau burden Alzheimer disease (AD). However, the vivo signal reflect aggregates remains controversial. <b>Methods:</b> We examined spatial pattern of binding, amyloid-β, tau, and gliosis an autopsy-confirmed AD patient who underwent <sup>11</sup>C-Pittsburgh compound B before death. <b>Results:</b> Regional was significantly correlated with density neocortex monoamine...
Background and purpose: Life style-related disorders such as hypertension, diabetes, dyslipidemia, obesity are reported to be a great risk of dementia. Adipocytokines released from adipose tissue thought modulate some brain functions including memory cognition. We here analysed adiponectin, one the most important adipocytokines, in plasma cerebrospinal fluid (CSF) cognitive normal controls (NC), mild impairment (MCI) subjects, patients with Alzheimer's disease (AD) discussed if/how...
Abstract Biomarkers in the cerebrospinal fluid ( CSF ) are currently regarded as indispensable indicators for accurate differential diagnosis of neurodegenerative disorders. Although high levels astrocyte‐secreted glial fibrillar acidic protein GFAP patients with Alzheimer's disease AD have been reported, not fully investigated other neurological disorders that cause dementia, such dementia Lewy bodies DLB and frontotemporal lobar degeneration FTLD ). In this study, we determined healthy...
Abstract The timing and characteristics of neuronal death in Alzheimer’s disease (AD) remain largely unknown. Here we examine AD mouse models with an original marker, myristoylated alanine-rich C-kinase substrate phosphorylated at serine 46 (pSer46-MARCKS), reveal increase necrosis during pre-symptomatic phase a subsequent decrease symptomatic phase. Postmortem brains mild cognitive impairment (MCI) rather than patients remarkable necrosis. In vivo imaging reveals instability endoplasmic...
Background [18F]THK5351, a recently-developed positron emission tomography (PET) tracer for measuring tau neurofibrillary tangle accumulation, may help researchers examine aging, disease, and pathology in living human brains. We examined THK5351 pharmacokinetics to define an optimal acquisition time static late images. Methods Primary measurements were calculation of regional values distribution volume ratios (DVR) standardized uptake value (SUVR) 6 healthy older control 10 Alzheimer's...
Visualization of pathogenic protein aggregates is crucial to elucidate pathomechanisms and make an accurate diagnosis in many neurodegenerative conditions. Aggregates the microtubule-binding protein, tau, are one most important molecules disorders. Progressive supranuclear palsy (PSP) characterized by deposition tau proteins some specific area such as basal ganglia brainstem. We tried detect lesions brains living patients with PSP a novel positron emission tomography (PET) tracer, [18...
Because the deposition of β-amyloid protein (Aβ) is a consistent pathological hallmark Alzheimer's disease (AD) brains, inhibition Aβ generation, prevention fibril formation, or destabilization preformed fibrils would be attractive therapeutic strategies for treatment AD. We examined effects several medicinal herbs used in traditional Chinese medical formulae on formation and by using thioflavin T binding assay, atomic force microscopic imaging, electrophoresis. Our study demonstrates that...
The formation of neurofibrillary tangles is believed to contribute the neurodegeneration observed in Alzheimer's disease (AD). Postmortem studies have shown strong associations between pathology and both neuronal loss severity cognitive impairment. However, temporal changes its association with progression are not well understood. Tau positron emission tomography (PET) imaging expected be useful for longitudinal assessment living brain. Here, we performed a PET study using tau-selective...
Rare non-synonymous variants of TREM2 have recently been shown to be associated with Alzheimer's disease (AD) in Caucasians. We here conducted a replication study using well-characterized Japanese sample set, comprising 2,190 late-onset AD (LOAD) cases and 2,498 controls. genotyped 10 (Q33X, Y38C, R47H, T66M, N68K, D87N, T96K, R98W, H157Y, L211P) reported by Guerreiro et al. (2013) means the TaqMan dideoxy sequencing methods. Only three variants, L211P, were polymorphic (range minor allele...
Abstract Amyloid β peptide (Aβ) has been implicated in Alzheimer's disease (AD) as an initiator of the pathological cascades. Several lines compelling evidence have supported major roles Aβ‐degrading enzyme neprilysin pathogenesis sporadic AD. Here, we shown a substantial reduction cerebrospinal fluid (CSF) activity (CSF‐NEP) patients with AD‐converted mild cognitive impairment and early AD compared age‐matched control subjects. The altered CSF‐NEP likely reflects changes neuronal...
Abstract Background This population-based retrospective cohort study aimed to clarify the impact of home and community-based services on hospitalisation institutionalisation individuals certified as eligible for long-term care insurance (LTCI) benefits. Methods Health data LTCI were combined into a database 1,020 in two farming communities Hokkaido who enrolled Citizen's Insurance. They had not received prior April 1, 2000 newly Long-Term Care Insurance benefits between February 29, 2008....
MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsTheme Sections 466:249-259 (2012) - DOI: https://doi.org/10.3354/meps09939 Spatio-temporal responses of black-tailed gulls natural and anthropogenic food resources Ken Yoda1,*, Naoki Tomita2,4, Yuichi Mizutani1, Akira Narita3, Yasuaki Niizuma2 1Graduate School Environmental Studies, Nagoya University, Furo-cho, Chikusa-ku,...
Telomeres are regarded as markers of biological or cellular ageing because they shorten with the degree stress exposure. Accordingly, telomere lengths should show different rates change when animals faced intensities environmental challenges. However, a relationship between length and environment has not yet been tested within natural setting. Here, we report longitudinal dynamics in free-living, black-tailed gulls (Larus crassirostris) through recapture birds known age over 2-5 consecutive...
Objectives To investigate the effects of lavender olfactory stimulation intervention on fall incidence in elderly nursing home residents. Design Randomized placebo‐controlled trial. Setting Three randomly selected homes northern J apan. Participants One hundred and forty‐five residents aged 65 older. Intervention were assigned to (n = 73) or placebo group 72) for a 360‐day study period. The received continuous from patch. an unscented Measurement primary outcome measure was resident falls....
Recent positron emission tomography (PET) studies have demonstrated the accumulation of tau PET tracer in affected region progressive supranuclear palsy (PSP) cases. To confirm binding target radiotracer PSP, we performed an imaging-pathology correlation study two autopsy-confirmed PSP patients who underwent [18F]THK5351 before death. One patient with Richardson syndrome showed elevated retention globus pallidus and midbrain. In a PSP-progressive nonfluent aphasia, also was observed cortical...