A5100753813- Palliative Care and End-of-Life Issues
- Childhood Cancer Survivors' Quality of Life
- Liver physiology and pathology
- Patient Dignity and Privacy
- Cell Adhesion Molecules Research
- Cancer survivorship and care
- Pediatric Hepatobiliary Diseases and Treatments
- Nanoparticle-Based Drug Delivery
- Genetic and Kidney Cyst Diseases
- Autophagy in Disease and Therapy
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Music Therapy and Health
- Endoplasmic Reticulum Stress and Disease
- Natural Antidiabetic Agents Studies
- Respiratory Support and Mechanisms
- Cannabis and Cannabinoid Research
- High Altitude and Hypoxia
- Regulation of Appetite and Obesity
- Neurological Disease Mechanisms and Treatments
- Venomous Animal Envenomation and Studies
- Bioactive Natural Diterpenoids Research
- Galectins and Cancer Biology
- Health and Well-being Studies
- Patient-Provider Communication in Healthcare
Sichuan University
2020-2024
Sino Biological (China)
2024
West China Hospital of Sichuan University
2020-2024
Wuhan No.9 Hospital
2024
Zunyi Medical University
2024
Beijing Geriatric Hospital
2018-2021
Capital Medical University
2021
The University of Texas MD Anderson Cancer Center
2020-2021
Beijing Anding Hospital
2021
Second Affiliated Hospital of Jilin University
2019
Background: Alzheimer’s disease (AD) is the most common type of dementia, affecting millions older people worldwide. However, pharmacological therapies have not achieved desirable clinical efficacy in past decades. Non-pharmacological been receiving increased attention to treat dementia recent years. Objective: This study explores effects music therapy on cognitive function and mental wellbeing patients with AD. Methods: A total number 298 AD mild, moderate, or severe participated study. The...
Activating beige adipocytes in white adipose tissue (WAT) to increase energy expenditure is a promising strategy combat obesity. We identified that mesencephalic astrocyte-derived neurotrophic factor (Manf) feeding-induced hepatokine. Liver-specific Manf overexpression protected mice against high-fat diet-induced obesity and promoted browning of inguinal subcutaneous WAT (iWAT). liver was also associated with decreased inflammation improved insulin sensitivity hepatic steatosis....
Abstract Liver fibrosis is characterized by excess reactive oxygen species (ROS) production, hepatic stellate cell (HSC) activation, and subsequent extracellular matrix deposition. Since complex pathways regulate HSC the single‐drug therapy efficacy for live often falls short of expectations. To address this issue, an HSC‐targeted multifunctional nanoparticle (NP) delivery system co‐loaded with cyclopamine (Cyc; hedgehog inhibitor) bilirubin (BR; ROS‐scavenger) designed. The NP, termed RHB,...
Abstract Diabetic nephropathy (DN) is a common clinically relevant complication of diabetes that associated with damage to the capillaries, yet etiology this condition remains unclear. Nuclear factor‐kappa B (NF‐κB) activation known be DN‐related inflammation and disease progression. Recent work indicated microRNAs are diagnostic biomarkers DN progression inflammation in DN. miR‐218 play key regulatory roles certain cancers humans, while its influence on pathology uncertain. The present...
Integration of specialist palliative care into routine oncologic improves patients' quality life and survival. National Comprehensive Cancer Network (NCCN) cancer treatment guidelines are instrumental in standardizing care, yet it is unclear how hospice integrated these guidelines. In this study, we examined the frequency occurrence "palliative care" "hospice NCCN compared between solid tumor hematologic malignancy guidelines.We reviewed all 53 updated Guidelines for Treatment Cancer. We...
Liver fibrosis is a common outcome of most chronic liver diseases, but there no clinically approved drug for its treatment. Previous studies have reported the potential SB431542 as an inhibitor TGF-β signaling in treatment fibrosis, it shows poor water solubility and low bioavailability. Here, we improve these characteristics by loading into liposomes (SB-Lips) with two FDA-approved excipients: soya phosphatidyl S100 Solutol HS15. In vitro, SB-Lips had stronger inhibitory effects on...
Renal fibrosis is the final manifestation of various chronic kidney diseases. Interstitial myofibroblasts, which are reported to highly express integrin αvβ3, effector cells in renal fibrogenesis. Since current therapies do not efficiently target these cells, there no effective therapeutic method for preventing or mitigating disease. Here, we modified sterically stable PEGylated liposomes with pentapeptide cRGDfC (RGD-Lip), has a high affinity specifically deliver drug interstitial...
Background: The choroid is involved directly or indirectly in many pathological conditions such as Alzheimer’s disease (AD), Parkinson’s (PD), and multiple sclerosis (MS). Objective: objective of this study was to investigate the association between retinal choroidal properties pathology AD by determining thickness, hippocampus volume, cognitive functions, plasma BACE1 activity. Methods: In cross-sectional study, 37 patients with 34 age-matched controls were included. Retinal thickness...
Exogenous neural stem cell (NSC) transplantation has become one of the most promising treatment methods for chronic stroke. Recent studies have shown that ischemia-reperfusion model rats recover spontaneously after injury, which limits ability to observe long-term behavioral recovery. Here, we used a severe stroke rat with 150 minutes ischemia, produced deficiencies persisted at 12 weeks, study therapeutic effect cells on restoration in Our showed treated human had sustained recovery motor...
Diabetes has been regarded as an independent risk factor for Alzheimer's disease (AD). Liraglutide could improve cognition in AD mouse models, but its precise mechanism remains unclear. In this study, we used STZ-induced diabetic rats and HT-22 cells to investigate the effects of liraglutide. The MWM test, MTT assay, ELISA, western blot, immunofluorescence were research. Diabetic induced by STZ displayed a longer escape latency entered target zone less frequently (p < 0.05) test....
To explore the mechanism of hyperbaric oxygen (HBO) intervention on acute lung injury secondary to