A5063786610- Transplantation: Methods and Outcomes
- Extracellular vesicles in disease
- Viral Infections and Immunology Research
- MicroRNA in disease regulation
- Renal Transplantation Outcomes and Treatments
- Cancer therapeutics and mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA Interference and Gene Delivery
- Respiratory viral infections research
- Immunotherapy and Immune Responses
- Drug Transport and Resistance Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Resistance in Bacteria
- Polyomavirus and related diseases
- Hepatitis B Virus Studies
- Cytomegalovirus and herpesvirus research
- Neutropenia and Cancer Infections
- Antimicrobial Peptides and Activities
- Organ Transplantation Techniques and Outcomes
- Vitamin D Research Studies
- Metal complexes synthesis and properties
- Hepatitis C virus research
- Bacteriophages and microbial interactions
- Mechanical Circulatory Support Devices
- Inhalation and Respiratory Drug Delivery
Maharishi Markandeshwar University, Mullana
2024-2025
St. Joseph's Hospital and Medical Center
2016-2025
Norton Healthcare
2024
Jamia Millia Islamia
2023
St. Joseph's Hospital
2019-2022
Tucson Orthopaedic Institute
2021
Dignity Health
2020
University of Illinois Urbana-Champaign
2016-2018
Jawaharlal Nehru University
2018
Regional Centre for Biotechnology
2013-2017
Abstract Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) causes severe syndrome. mRNA vaccines directed at the SARS-CoV-2 spike protein resulted in development of Abs and protective immunity. To determine mechanism, we analyzed kinetics induction circulating exosomes with Ab following vaccination healthy individuals. Results demonstrated expressing on day 14 after followed by d second dose. Exosomes protein, to spike, T cells secreting IFN-γ TNF-α increased booster Transmission...
Automatic Sign Language Recognition Systems (ASLR) offers smooth communication between hearing-impaired and normal-hearing individuals, enhancing educational opportunities for impaired. However, it struggles with "curse of dimensionality" due to excessive features resulting in prolonged training time exhaustive computational demand. This paper proposes technique that integrates machine learning swarm intelligence effectively address this issue. The proposed technique, initially, extracts...
We have synthesized two series of bile acid tamoxifen conjugates using three acids lithocholic (LCA), deoxycholic (DCA), and cholic (CA). These acid-tamoxifen possess 1, 2, 3 molecules attached to hydroxyl groups having free amine functionalities at the tail region acids. The in vitro anticancer activities these show that headgroup based conjugate (CA-Tam3-Am) is most potent as compared parent drug other conjugates. bearing shows enhanced both estrogen receptor +ve -ve breast cancer cell...
Abstract Naturally occurring antimicrobial peptides (AMPs) are powerful defence tools to tackle pathogenic microbes. However, limited natural production and high synthetic costs in addition poor selectivity limit large‐scale use of AMPs clinical settings. Here, we present a series (SAMPs) that exhibit highly selective potent killing Mycobacterium (minimum inhibitory concentration <20 μg mL −1 ) over E. coli or mammalian cells. These SAMPs active against rapidly multiplying as well growth...
Bisphosphonates are a major class of drugs used to treat osteoporosis, Paget's disease, and cancer. They have been proposed act by inhibiting one or more targets including protein prenylation, the epidermal growth factor receptor, adenine nucleotide translocase. Inhibition latter is due formation in cells analogs ATP: isopentenyl ester ATP (ApppI) an AppXp-type analog ATP, such as AMP-clodronate (AppCCl2p). We screened both ApppI well AppCCl2p against panel 369 kinases finding potent...
Antibiotic resistance in bacterial pathogens is a serious clinical problem. Novel targets are needed to combat increasing drug Escherichia coli. Our objective demonstrate that 2-(3,4-dimethoxyphenyl)-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2yl]-1H-benzimidazole (DMA) inhibits E. coli DNA topoisomerase I more strongly than human I. In addition, DMA non-toxic mammalian cells at antibiotic dosage level. the present study, we have established as an antibacterial compound by determining...
We report the enhanced anticancer activities of lithocholic acid amphiphiles possessing different charged head group for colon cancer therapy.
Hard-charged amphiphiles are highly selective against mycobacteria, whereas soft-charged active Gram-positive and Gram-negative bacteria.