Zhifu Chen

ORCID: 0000-0003-0639-1148
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Research Areas
  • Galaxies: Formation, Evolution, Phenomena
  • Astrophysical Phenomena and Observations
  • Stellar, planetary, and galactic studies
  • Gamma-ray bursts and supernovae
  • Astronomy and Astrophysical Research
  • Astrophysics and Cosmic Phenomena
  • Antibiotic Resistance in Bacteria
  • Astro and Planetary Science
  • Astrophysics and Star Formation Studies
  • Radio Astronomy Observations and Technology
  • Antimicrobial Resistance in Staphylococcus
  • Clostridium difficile and Clostridium perfringens research
  • Distributed Control Multi-Agent Systems
  • Antimicrobial Peptides and Activities
  • Immune Response and Inflammation
  • Bone Tumor Diagnosis and Treatments
  • Advanced Thermoelectric Materials and Devices
  • Sarcoma Diagnosis and Treatment
  • Cosmology and Gravitation Theories
  • Bacteriophages and microbial interactions
  • Pulsars and Gravitational Waves Research
  • Scientific Research and Discoveries
  • Black Holes and Theoretical Physics
  • Non-Destructive Testing Techniques
  • Escherichia coli research studies

Army Medical University
2018-2025

National University of Pharmacy
2025

Army Medical College
2025

Chinese Academy of Sciences
2022-2024

Minzu University of China
2023-2024

Institute of Electrical Engineering
2022-2024

Shenzhen University
2024

Midea Group (China)
2022-2023

Kunming Medical University
2022-2023

Guangxi University for Nationalities
2018-2022

Abstract It is commonly accepted that outflows from the central regions of quasars play a substantial role in regulating global properties host galaxy. These are typically detected through blueshifted absorption lines. However, question remains whether observed with different line types indeed reflect same environmental or evolutionary stage In this study, we use Sloan Digital Sky Survey quasar catalog and employ flux ratio [O II ] [Ne V] emission lines as indicators to compare star...

10.3847/1538-4357/ad1e5e article EN cc-by The Astrophysical Journal 2024-02-21

Abstract In active galactic nuclei, jet-driven feedback plays a significant role in influencing the properties of gas within their host galaxy and circumgalactic medium. By combining observations from Very Large Array Sky Survey, Faint Images Radio at Twenty-cm, LOFAR Two Meter Sloan Digital Survey (SDSS), we assembled sample 3141 radio-loud quasars, among which 418 exhibit Mg ii -associated absorption lines SDSS spectra. We classify these quasars into evolutionary stages based on radio...

10.3847/1538-4357/adaea2 article EN cc-by The Astrophysical Journal 2025-02-12

Abstract Some optically selected quasars exhibit Mg ii- associated absorption lines (AALs), and their origin remains unclear. In this paper, we compile a sample of 1769 quasars, with or without ii AALs, which 1689 are far-infrared (FIR) detected the rest not in FIR. For FIR undetected obtain stacks for both AAL quasars. Then, estimate star formation rates (SFRs) within quasar host galaxies based on luminosities derived from graybody components, find that, although AALs have significantly...

10.3847/1538-4357/adbf1c article EN cc-by The Astrophysical Journal 2025-04-04

Multidrug-resistant Gram-positive superbugs pose a significant menace to global public health, urgently demanding the advent of novel antibiotics. In this study, three biphenyl sulfonium lipoglycopeptides derived from vancomycin were rationally designed and synthesized combat such resistance. Among them, most promising derivative, BD-V-2, exhibited outstanding in vitro activity against diverse array refractory strains. Notably, two highly challenging lethal sepsis models induced by MRSA VREm...

10.1021/jacs.4c18630 article EN Journal of the American Chemical Society 2025-04-08

Gram-positive superbugs resistant to methicillin and vancomycin pose a severe threat global public health, urgently demanding novel therapeutic strategies. Herein, we rationally designed synthesized derivatives modified with diverse aryl sulfonium moieties reactivate its antibacterial potency. By optimizing the sulfonium-based SAR, got 2-3 orders of magnitude more active in vitro than vancomycin. Subsequently, preliminary toxicity evaluations for optimal derivative, 7e, indicated favorable...

10.1021/acs.jmedchem.4c03028 article EN Journal of Medicinal Chemistry 2025-04-12

Gamma-ray bursts (GRBs) are believed to belong two classes and they conventionally divided according their durations. This classification scheme is not satisfied due the fact that duration distributions of heavily overlapped. We collect a new sample (153 sources) GRBs investigate distribution logarithmic deviation Ep value from Amati relation. The possesses an obvious bimodality structure it can be accounted for by combination Gaussian curves. Based on this analysis, we propose statistically...

10.1093/mnras/sts547 article EN Monthly Notices of the Royal Astronomical Society 2013-01-25

The emergence of drug-resistant strains Klebsiella pneumoniae (K. pneumoniae) has become a significant challenge in the field infectious diseases, posing an urgent need for development highly protective vaccines against this pathogen. In study, we identified three immunogenic extracellular loops based on structure five candidate antigens using sera from K. infected mice. sequences these were linked to C-terminal alpha-hemolysin mutant (mHla) Staphylococcus aureus generate heptamer, termed...

10.1016/j.biopha.2024.116611 article EN cc-by Biomedicine & Pharmacotherapy 2024-04-21

Context. In recent years, some polarization measurements of gamma-ray bursts (GRBs) have been reported, and the polarization-angle (PA) rotation in prompt emission phase has found several bursts. The physical mechanism PA evolution is still unclear. this work, we studied origin a toroidal magnetic field. Aims. We aim to provide an explanation for GRBs find conditions that lead by 90 degrees magnetic-field (MF) model. Moreover, present observable properties MF model can be tested future....

10.1051/0004-6361/202348050 article EN cc-by Astronomy and Astrophysics 2024-05-07

We assemble 3524 quasars from Sloan Digital Sky Survey (SDSS) with repeated observations to search for variations of narrow C IV1548,1551 and Mg II2796,2803 absorption doublets in spectral regions shortward 7000 Ang at the observed frame, which corresponds time-scales about 150 ~ 2643 days quasar rest frame. In these spectra, we detect 3580 IV systems z_{abs} = 1.5188 3.5212, 1809 II 0.3948 1.7167. term absorber velocity (beta) distribution find a substantial number absorbers beta<0.06,...

10.1093/mnras/stv813 article EN Monthly Notices of the Royal Astronomical Society 2015-05-19

Pneumonia caused by Acinetobacter baumannii has become a serious threat to the elderly. However, there are no experimental studies on relevance between aging and A. infections. Here, we established an aged pneumonia mouse model non-invasive intratracheal inoculation with baumannii. Higher mortality was observed in mice along increased bacterial burdens more severe lung injury. Increased inflammatory cell infiltration enhanced pro-inflammatory cytokines at 24 hours post infection were...

10.18632/aging.101495 article EN cc-by Aging 2018-07-18

Vancomycin and norvancomycin have diminished antibacterial efficacy due to acquired or intrinsic resistance from mutations in the terminal dipeptide of lipid II Gram-positive bacteria failure penetrate into periplasm Gram-negative bacteria. Herein, we rationally designed synthesized a series vancomycin analogues bearing single amine guanidine functionality, altering various linkers modification sites, combat resistance. Extensive screening was performed delineate comprehensive SAR. Many...

10.1021/acs.jmedchem.4c02196 article EN Journal of Medicinal Chemistry 2024-11-06

10.1016/j.physa.2012.03.015 article EN Physica A Statistical Mechanics and its Applications 2012-03-18

Innate immune effectors constitute the first line of host defense against pathogens. However, roles these are not clearly defined during Klebsiella pneumoniae (K. pneumoniae) respiratory infection. In current study, we established an acute pneumonia model K. infection in mice and confirmed that injury was most severe 48 h post Flow cytometric assay demonstrated alveolar macrophages were predominant cells BALF before infection, neutrophils quickly recruited after this consistent with kinetics...

10.1155/2020/5291714 article EN cc-by Journal of Immunology Research 2020-10-24

With the advent of digital age, real-time monitoring, diagnosis, and control become essential demands in life-cycle management electrical equipment. The methods for behavior modeling that allows accurate physical simulation gain increasing attention recent years. Construction model a parametric space needs large amount data based on physics which is very time-consuming. This work proposes methodology by using order reduction (MOR) technique proper orthogonal decomposition (POD) to build...

10.1109/tmag.2022.3187620 article EN IEEE Transactions on Magnetics 2022-07-01

In this paper, we report on two C iv narrow absorption systems emerging from the spectrum of quasar SDSS J095254.10+021932.8, which are located at zabs = 2.0053 and 1.8011, respectively. These features have velocity offsets ∼13 800 ∼34 700 km s−1 with respect to quasar, show obviously partial coverage background emission sources. The imprinted obtained by Sloan Digital Sky Survey (SDSS) III 2011 March 25, cannot be observed SDSS-I/II 2000 December 30. time interval observations is 1186.4 d...

10.1093/mnras/stt1247 article EN Monthly Notices of the Royal Astronomical Society 2013-08-10

Abstract Using the quasar spectra from Sloan Digital Sky Survey, all with two-epoch to six-epoch observations, we search for C IV λλ 1548,1551 narrow absorption doublets in spectral data blue wing υ r = 30,000 km s −1 until red of λ 1549 emission lines. We have obtained 21,239 line (NAL) systems, which 647 systems were significantly changed on timescales ΔMJD 0.24 1842.38 days at rest-frame. Both samples NAL multi-epoch observations and variable are largest ones date. The offset velocity...

10.3847/1538-4365/aaeac3 article EN The Astrophysical Journal Supplement Series 2018-12-01

Abstract Using the SDSS spectra of quasars included in DR7Q or DR12Q catalogs, we search for Mg ii λλ 2796, 2803 narrow absorption doublets data around λ 2798 emission lines. We obtain 17,316 doublets, within redshift range 0.3299 ≤ z abs 2.5663. find that a velocity offset υ r &lt; 6000 km s −1 is safe boundary to constrain vast majority associated systems, although some at &gt; . If absorbers are defined by , ∼33.3% supposed be contaminants intervening systems. Removing 33.3% contaminants,...

10.3847/1538-4365/aaaaec article EN The Astrophysical Journal Supplement Series 2018-03-01

Quasar J152645.61+193006.7 (ze = 2.5771) was observed by the Sloan Digital Sky Survey (SDSS) on 2006 May 31 and again 2011 April 9. The time interval of SDSS two observations is 497.4 days at quasar rest frame. From spectra this quasar, we detect a phenomenon disappearance narrow absorption system with velocity up to 166, 129 km s−1 respect quasar. This event can be caused changes in ionization state absorbing gas or bulk motion across sightline. coverage fraction analysis shows that...

10.1088/0004-637x/777/1/56 article EN The Astrophysical Journal 2013-10-17

Abstract We assemble 207 variable quasars from the Sloan Digital Sky Survey, all with at least 3 observations, to analyze C iv narrow absorption doublets, and obtain 328 line systems. find that 19 out of systems were changed by <?CDATA $| {\rm{\Delta }}{W}_{r}^{\lambda 1548}| \geqslant 3{\sigma }_{{\rm{\Delta 1548}}$?> on timescales 15.9 1477 days rest-frame. Among obviously systems, we (1) 14 have relative velocities ${\upsilon }_{r}\gt 0.01c$?> 4 0.1c$?> , where c is speed light; (2) 13...

10.3847/1538-4365/aabcd4 article EN The Astrophysical Journal Supplement Series 2018-06-01
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