A5061182026- Extracellular vesicles in disease
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer survivorship and care
- Bladder and Urothelial Cancer Treatments
- MicroRNA in disease regulation
- Cancer-related cognitive impairment studies
- Neuropeptides and Animal Physiology
- Epigenetics and DNA Methylation
- Testicular diseases and treatments
- RNA modifications and cancer
- Medical Imaging and Pathology Studies
- Sarcoma Diagnosis and Treatment
- Bone health and treatments
- Pancreatic function and diabetes
- Renal and related cancers
- Multiple and Secondary Primary Cancers
- Tryptophan and brain disorders
- Diabetes and associated disorders
- Genetics and Neurodevelopmental Disorders
- Chemokine receptors and signaling
- Beetle Biology and Toxicology Studies
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Nanoplatforms for cancer theranostics
- nanoparticles nucleation surface interactions
IPO Porto
2021-2024
Centre National de la Recherche Scientifique
2024
Institut Cochin
2024
Université Paris Cité
2024
Inserm
2024
Instituto Português de Oncologia Francisco Gentil
2021-2024
Universidade do Porto
2021-2023
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2021-2023
Abstract Extracellular vesicles (EVs) are lipid-membrane enclosed structures that associated with several diseases, including those of genitourinary tract. Urine contains EVs derived from urinary tract cells. Owing to its non-invasive collection, urine represents a promising source biomarkers for disorders, cancer. The most used method separation is differential ultracentrifugation (UC), but current protocols lead significant loss hampering efficiency. Moreover, UC labor-intensive, further...
Epidemiological studies and preclinical models suggest that chronic stress might accelerate breast cancer (BC) growth the development of metastasis via sympathetic neural mechanisms. Nevertheless, role each adrenergic pathway (α1, α2, β) in human samples remains poorly depicted. Herein, we propose to characterize profile system (e.g., release catecholamines, expression catecholamine metabolic enzymes adrenoreceptors) BC patients, ascertain its relevance distant metastasis. Our results...
This study aimed to evaluate the efficacy of a purification method developed for isolating alpha, beta, and delta cells from pancreatic islets adult mice, extending its application newborn aged mice. Furthermore, it sought examine transcriptome dynamics in mouse endocrine islet throughout postnatal development validate age-related alterations within these cell populations.
The sympathetic nervous system (SNS), particularly through the β2 adrenergic receptor (β2-AR), has been linked with breast cancer (BC) and development of metastatic BC, specifically in bone. Nevertheless, potential clinical benefits exploiting β2-AR antagonists as a treatment for BC bone loss-associated symptoms remain controversial. In this work, we show that, when compared to control individuals, epinephrine levels cohort patients are augmented both earlier late stages disease....
Mindfulness-based interventions (MBIs) have been used in oncology contexts as a promising tool with numerous benefits for various health-related and psychosocial outcomes. Despite the increasing popularity of MBIs, few randomized controlled trials (RCTs) examined their effects upon biological parameters. Specifically, no previous study has MBIs on extracellular vesicles (EVs), which are potentially important markers health, disease, stress. Moreover, lack RCTs is even more limited within...
Abstract BackgroundMindfulness-based interventions (MBIs) have been used in oncology contexts as a promising tool with numerous benefits for various health-related and psychosocial outcomes. Despite the increasing popularity of MBIs, few randomized controlled trials (RCTs) examined their effects upon biological parameters. Specifically, no previous study has MBIs on extracellular vesicles (EVs), which are potentially important markers health, disease, stress. Moreover, lack RCTs is even more...