A5101597918- Clinical Nutrition and Gastroenterology
- Intestinal Malrotation and Obstruction Disorders
- Cellular Mechanics and Interactions
- Tissue Engineering and Regenerative Medicine
- Digestive system and related health
- Congenital heart defects research
- Congenital Diaphragmatic Hernia Studies
- Retinal Development and Disorders
- Photoreceptor and optogenetics research
- Corneal Surgery and Treatments
- Infant Nutrition and Health
- Neuroscience and Neural Engineering
- Connexins and lens biology
- Cell Adhesion Molecules Research
- Planarian Biology and Electrostimulation
- 3D Printing in Biomedical Research
- Cardiomyopathy and Myosin Studies
- Congenital Anomalies and Fetal Surgery
- Corneal surgery and disorders
- Pancreatic and Hepatic Oncology Research
- Congenital Heart Disease Studies
Stanford University
2019-2023
University of California, Los Angeles
2019
Washington University in St. Louis
2014-2018
Abstract Small animals do not replicate the severity of human foreign-body response (FBR) to implants. Here we show that FBR can be driven by forces generated at implant surface that, owing allometric scaling, increase exponentially with body size. We found is mediated immune-cell-specific RAC2 mechanotransduction signalling, independently chemistry and mechanical properties implant, a pathological human-like molecular, cellular tissue levels induced in mice via application...
For decades, it was commonly thought that the bilateral heart fields in early embryo fold directly toward midline, where they meet and fuse to create primitive tube. Recent studies have challenged this view, however, suggesting diagonally. Since foregut tube morphogenesis are intimately related, finding also raises questions concerning traditional view of formation. Here, we combine experiments on chick embryos with computational modeling explore a new hypothesis for physical mechanisms...
Distraction enterogenesis has been extensively studied as a potential treatment for short bowel syndrome, which is the most common form of intestinal failure. Different strategies including parenteral nutrition and surgical lengthening to manage patients with syndrome are associated high complication rates. More recently, self-expanding springs have used lengthen small intestine using an intraluminal axial mechanical force, where this biomechanical force stimulates growth elongation...
Abstract For decades, it has been assumed that the foreign body response (FBR) to biomedical implants is primarily a reaction chemical and mechanical properties of implant. Here, we show for first time third independent variable, allometric tissue-scale forces (which increase exponentially with size), can drive biology FBR in humans. We demonstrate pathological humans mediated by immune cell-specific Rac2 mechanotransduction signaling, implant chemistry or properties. then mice, which are...