A5064950430- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Memory and Neural Mechanisms
- Virus-based gene therapy research
- Protein Kinase Regulation and GTPase Signaling
- Neurotransmitter Receptor Influence on Behavior
- RNA Interference and Gene Delivery
- Alzheimer's disease research and treatments
- Neural dynamics and brain function
- Nerve injury and regeneration
- Phosphodiesterase function and regulation
- RNA regulation and disease
- Neuroendocrine regulation and behavior
- CRISPR and Genetic Engineering
- Nicotinic Acetylcholine Receptors Study
University of Castilla-La Mancha
2011-2024
Institut de Biomedicina de la Universitat de Barcelona
2024
Innsbruck Medical University
2024
Universität Innsbruck
2024
Universidad de Navarra
2021-2022
Biomedical Research Networking Center on Neurodegenerative Diseases
2021-2022
Navarre Institute of Health Research
2021-2022
University of South Carolina
2017
In the hippocampus, inhibitory neurotransmitter GABA shapes activity of output pyramidal neurons and plays important role in cognition. Most its effects are mediated by signaling from GABAB receptor to G protein-gated Inwardly-rectifying K+ (GIRK) channels. Here, we show that RGS7, cooperation with binding partner R7BP, regulates GABABR-GIRK hippocampal neurons. Deletion RGS7 mice dramatically sensitizes GIRK responses stimulation markedly slows channel deactivation kinetics. Enhanced this...
Enhanced glutamatergic neurotransmission in dopamine (DA) neurons of the ventral tegmental area (VTA), triggered by a single cocaine injection, represents an early adaptation linked to more enduring effects abused drugs that characterize addiction. Here, we examined impact vivo exposure on metabotropic inhibitory signaling involving G-protein-gated inwardly rectifying K(+) (Girk) channels VTA DA neurons. Somatodendritic Girk currents evoked GABA(B) receptor (GABA(B)R) agonist baclofen were...
In the hippocampus, signaling through G protein-coupled receptors is modulated by Regulators of protein (Rgs) proteins, which act to stimulate rate GTP hydrolysis, and consequently, inactivation. The R7-Rgs subfamily selectively deactivates G(i/o)-class Gα subunits that mediate action several GPCRs. Here, we used co-immunoprecipitation, electrophysiology immunoelectron microscopy techniques investigate formation macromolecular complexes spatial relationship Rgs7/Gβ5 its prototypical...
Abstract Subtype 5 metabotropic glutamate receptors (mGlu ) are known to play an important role in regulating cognitive, social and valence systems. However, it remains largely unknown at which circuits neuronal types mGlu act influence these behavioral domains. Altered tissue- or cell-specific expression function of has been proposed contribute the exacerbation neuropsychiatric disorders. Here, we examined how regulate activity somatostatin-expressing (SST+) neurons, as well their on...
The neuromodulatory effects of GABA on pyramidal neurons are mediated by B receptors (GABA Rs) that signal via a conserved G-protein-coupled pathway. Two prominent effectors regulated Rs include G-protein inwardly rectifying K + (GIRK) and P/Q/N type voltage-gated Ca 2+ (Ca V 2) ion channels control excitability synaptic output these neurons, respectively. Regulator signaling 7 (RGS7) has been shown to effects, yet the specificity its impacts effector underlying molecular mechanisms is...
Abstract Voltage‐gated Ca V 2.1 (P/Q‐type) 2+ channels play a crucial role in regulating neurotransmitter release, thus contributing to synaptic plasticity and processes such as learning memory. Despite their recognized importance neural function, there is limited information on potential involvement neurodegenerative conditions Alzheimer's disease (AD). Here, we aimed explore the impact of AD pathology density nanoscale compartmentalization hippocampus association with GABA B receptors....
A member of regulator G-protein signaling family, RGS7, is an essential modulator through GABAB receptors. RGS7 functions as a macromolecular complex with type 5 G protein β (Gβ5) and R7 binding (R7BP) to control the localization function resultant heterotrimeric complexes. Here, we used co-immunoprecipitation, in situ hybridization, histoblot immunohistochemical techniques at light electron microscopic level advance understanding RGS7-Gβ5-R7BP complexes central nervous system, focusing on...