A5012616191- Lipid metabolism and biosynthesis
- Cancer, Lipids, and Metabolism
- Fatty Acid Research and Health
- Nutrition and Health in Aging
- Frailty in Older Adults
- Respiratory viral infections research
- Cancer Cells and Metastasis
- SARS-CoV-2 and COVID-19 Research
- Cancer, Hypoxia, and Metabolism
- COVID-19 Clinical Research Studies
- Polyamine Metabolism and Applications
- Prostate Cancer Treatment and Research
- Protein Hydrolysis and Bioactive Peptides
- Microbial Metabolic Engineering and Bioproduction
- Sexual Differentiation and Disorders
- Hormonal and reproductive studies
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- Occupational and environmental lung diseases
- Cancer-related gene regulation
- Cancer Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Endoplasmic Reticulum Stress and Disease
- Genomics, phytochemicals, and oxidative stress
- 14-3-3 protein interactions
Norwegian University of Science and Technology
2008-2023
St Olav's University Hospital
2018-2023
Ålesund Hospital
2023
KITH (Norway)
2017
Abstract Background Cancer cachexia is a syndrome of weight loss (including muscle and fat), anorexia, decreased physical function. It has been suggested that the optimal treatment for should be multimodal intervention. The primary aim this study was to examine feasibility safety intervention (n‐3 polyunsaturated fatty acid nutritional supplements, exercise, anti‐inflammatory medication: celecoxib) cancer in patients with incurable lung or pancreatic cancer, undergoing chemotherapy. Methods...
As of June 2020, the number people infected with severe acute respiratory coronavirus 2 (SARS-CoV-2) continues to skyrocket, more than 6.7 million cases worldwide. Both World Health Organization (WHO) and United Nations (UN) has highlighted need for better control SARS-CoV-2 infections. However, developing novel virus-specific vaccines, monoclonal antibodies antiviral drugs against can be time-consuming costly. Convalescent sera safe-in-man broad-spectrum antivirals (BSAAs) are readily...
Background Malignant pleural mesothelioma is considered an almost incurable tumour with increasing incidence worldwide. It usually develops in the parietal pleura, from mesothelial lining or submesothelial cells, subsequently invading visceral pleura. Chromosomal and genomic aberrations of are diverse heterogenous. Genome-wide profiling versus normal tissue could thus reveal novel genes pathways explaining its aggressive phenotype. Methodology Principal Findings Well-characterised five...
Polyunsaturated fatty acids (PUFAs) are important constituents of the diet and health benefits omega-3/n−3 PUFAs, especially eicosapentaenoic acid (EPA, 20:5 n−3) docosahexaenoic (DHA, 22:6 have been well documented in relation to several diseases. Increasing evidence suggests that n−3 PUFAs may anticancer activity improve effect conventional cancer therapy. The mechanisms behind these effects still unclear need be elucidated. We examined DHA-induced stress response two human colon cell...
Diets rich in n-3 polyunsaturated fatty acids (PUFAs) have been associated with a reduced risk of several types cancer. Recent reports suggested that these PUFAs enhance the cytotoxic effect cancer chemoradiotherapy. The docosahexaenoic acid (DHA) on key cell cycle regulators and target proteins therapy was investigated human malign colon line SW620. Cell check point such as p21 stratifin (14-3-3 sigma) increased at mRNA protein level, whereas progression division 25 homolog cyclin-dependent...
Abstract As of June 2020, the number people infected with severe acute respiratory coronavirus 2 (SARS-CoV-2) continues to skyrocket, more than 6,5 million cases worldwide. Both World Health Organization (WHO) and United Nations (UN) has highlighted need for better control SARS-CoV-2 infections. However, developing novel virus-specific vaccines, monoclonal antibodies antiviral drugs against can be time-consuming costly. Convalescent sera safe-in-man broad-spectrum antivirals (BSAAs) are...
Colorectal cancer (CRC) is one of the most common types worldwide. Chemotherapy toxic to normal cells, and combinatory treatment with natural well-tolerated products being explored. Some omega-3 polyunsaturated fatty acids (n-3 PUFAs) marine fish oils have anti-cancer effects on CRC cells. The salmon oil OmeGo (Hofseth BioCare) contains a spectrum acids, including n-3 PUFAs docosahexaenoic acid (DHA) eicosahexaenoic (EPA). We explored potential effect four cell lines DLD-1, HCT-8, LS411N,...
Studies show that n-3 polyunsaturated fatty acids (PUFA) inhibit proliferation and induce apoptosis in cancer cells. Recent reports indicate this effect is due to activation of the unfolded protein response (UPR). However, what causes has been unclear. We examined effects eicosapentaenoic acid (EPA) on human leukemia cell line HL60 econazole (Ec) resistant clone E2R2. Ec depletes Ca(2+) from ER blocks influx mammalian cells, leading UPR apoptosis. EPA inhibited growth cells strongly, while...
Background: New clinical trials in cancer cachexia are essential, and outcome measures with high responsiveness to detect meaningful changes crucial. This secondary analysis from a multimodal intervention trial estimates sensitivity change between treatment effect sizes (ESs) of associated body composition, physical function, metabolism, intervention. Methods: The study was multicenter, open-label, randomized pilot investigating the feasibility 6-week [exercise, non-steroidal...
The omega‐3 fatty acid docosahexaenoic ( DHA ) is known as an anticancer agent. Colorectal cancer CRC cells exhibit different sensitivity toward , but the mechanisms involved are still unclear. Gene expression profiling of 10 cell lines demonstrated a correlation between level and biological stress responses, such endoplasmic reticulum ER stress, oxidative autophagy. basal autophagy MAP 1 LC 3B‐ II protein correlated with in studied. induced ‐sensitive DLD ‐1 cells, while less sensitive LS...
Prostate cancer is a common cause of death in men. In advanced stages prostate cancer, androgen deprivation therapy (ADT) initiated. Despite ADT, cancers invariably progress to become independent. A growing body evidence implicates iron dysmetabolism progression. bioactive peptide-rich salmon protein hydrolysate (SPH) has previously been demonstrated modulate homeostatic mechanisms. the present study, anticancer effect SPH and bicalutamide co-treatment on LNCaP PC3 cell proliferation was...
Cancer patient-derived xenografts (PDXs) better preserve tumor characteristics and microenvironment than traditional cancer cell line derived are becoming a valuable model in translational research personalized medicine. We have established PDX for colorectal (CRC) CIEA NOG mice with 50% engraftment rate. Tumor fragments from patients CRC (n = 5) were engrafted four per 20). Mice PDXs received liquid diet enriched fish oil or placebo, fatty acid profiling was performed to measure content...