A5034623906- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Hedgehog Signaling Pathway Studies
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Cancer-related Molecular Pathways
- Congenital Ear and Nasal Anomalies
- Immunodeficiency and Autoimmune Disorders
- Genomics and Chromatin Dynamics
- Acute Myeloid Leukemia Research
- Peptidase Inhibition and Analysis
- Adipose Tissue and Metabolism
- Receptor Mechanisms and Signaling
- Protein Degradation and Inhibitors
- Mechanisms of cancer metastasis
University of New Hampshire
2019-2025
Methamphetamine (METH) is a potent psychostimulant that disrupts cognitive and neurobiological functions in brain regions such as the prefrontal cortex (PFC) hippocampus. Chronic METH use leads to altered synaptic plasticity, neuroinflammation, mitochondrial dysfunction, contributing methamphetamine disorder (MUD). This study investigates gene expression changes following long-access intravenous self-administration rodent model. RNA sequencing (RNA-Seq) was conducted on PFC hippocampal...
Methamphetamine (METH) is a potent psychostimulant that disrupts cognitive and neurobiological functions in brain regions such as the prefrontal cortex (PFC) hippocampus. Chronic METH use leads to altered synaptic plasticity, neuroinflammation, mitochondrial dysfunction, contributing methamphetamine disorder (MUD). This study investigates gene expression changes following long-access intravenous self-administration rodent model. RNA sequencing (RNA-Seq) was conducted on PFC hippocampal...
Aim: Waldenström macroglobulinemia (WM) is a low-grade B-cell lymphoma characterized by overproduction of monoclonal IgM. To date, there are no therapies that provide cure for WM patients, and therefore, it important to explore new therapies. Little known about the efficiency epigenetic targeting in WM. Materials & methods: cells were treated with BET inhibitors (JQ1 I-BET-762) venetoclax, panobinostat or ibrutinib. Results: inhibition reduces growth cells, little effect on survival. This...
// Stephan J. Matissek 1 , Mona Karbalivand Weiguo Han Ava Boutilier Estefania Yzar-Garcia Laura L. Kehoe Devin Storm Gardner Adam Hage 2 Krista Fleck Vicki Jeffers Ricardo Rajsbaum 3 and Sherine F. Elsawa Department of Molecular, Cellular Biomedical Sciences, University New Hampshire, Durham, NH, USA Microbiology Immunology, Texas Medical Branch, Galveston, TX, Institute for Human Infections Immunity, Correspondence to: Elsawa, email: sherine.elsawa@unh.edu Keywords: GLI3; inflammation; TLR...
Abstract The transcription factor GLI3 is a member of the GLI family and has been shown to be regulated by canonical hedgehog (HH) signaling through smoothened (SMO). Little known about SMO-independent regulation GLI3. Here, we identify TLR as novel pathway regulating expression. We show that expression induced LPS/TLR4 in human monocyte cell lines peripheral blood CD14 + cells. Further analysis identified TRIF, but not MyD88, adapter used TLR4 regulate Using pharmacological genetic tools,...