There is growing evidence of the dietary impact on obesity-induced low-grade chronic inflammation and associated non-communicable diseases modification. We determined changes in body composition cardiometabolic inflammatory status participants with obesity after 24 weeks a intervention based an energy-reduced anti-inflammatory diet examined relationship these potential diet. The anthropometric parameters 81 (average age 43 years, 74 women) were assessed. Metabolic was using glycemic lipid...

Infections are leading causes of increased morbidity and mortality severe traumatic brain-injured (STBI) patients. The mechanism underlying the susceptibility to infections is still unexplained. purpose study was investigate changes in frequency leucocytes subpopulations peripheral blood patients with STBI during course intensive care treatment. Twenty were included study. Healthy age- sex- volunteers served as control. Peripheral samples taken from these at day 1, 4 7, mononuclear cells...

This study aimed to examine whether the oral supplementation of vitamins C and E during a seven-day high salt diet (HS; ~14 g salt/day) prevents microvascular endothelial function impairment changes oxidative status caused by HS in 51 (26 women 25 men) young healthy individuals. Laser Doppler flowmetry measurements demonstrated that skin post-occlusive reactive hyperemia (PORH), acetylcholine-induced dilation (AChID) were significantly impaired group, but not HS+C+E while sodium...

Abstract Background Metabolic syndrome (MetS) is a global public health concern, although its association with the inflammatory potential of diet still indefinite. The main objective present study was to investigate MetS and components in Croatian working population sedentary occupations. Methods In cross‐sectional study, workers ( n = 366) self‐administrated questionnaires for sociodemographic health‐related data. Their anthropometric measurements fasting blood samples were collected...

Background. Associated with epidemics of obesity, nonalcoholic fatty liver disease (NAFLD) is becoming the most prevalent worldwide. The cornerstone therapy for NAFLD lifestyle intervention, mainly focused on weight loss. Significant loss results from energy-restricted diets, regardless macronutrient distribution. An anti-inflammatory diet was related to lower odds among daily alcohol drinkers and individuals metabolic syndrome. This study aims evaluate effect an energy-reduced status in...

To investigate the changes in venoarterial carbon-dioxide gradient (V-a Pco(2)) and its prognostic value for survival of patients with severe sepsis septic shock.The study was conducted General Hospital Holy Spirit from January 2004 to December 2007 included 71 conveniently sampled adult (25 women 46 men), who fulfilled shock criteria were followed a median 8 days (interquartile range, 12 days). The divided two groups depending on whether or not they had been mechanically ventilated. Both...

To elucidate the role of metallothioneins (MTs) in pathomechanisms autoimmune CNS disorders we estimated expression MTs I+II and tissue concentrations Zn2+ Cu2+ brain, spinal cord (SC) liver during periods attacks remissions chronic relapsing experimental encephalomyelitis (CR-EAE). Disease was induced genetically susceptible Dark Agouti (DA) rats by subcutaneous injection bovine brain homogenate CFA. Control were treated with CFA or saline solution. The data, obtained clinical assessment,...

Changes in immune and inflammatory responses may play a crucial role the development progression of atherosclerosis, as an autoimmune, chronic progressive disease. Immunological activity vascular inflammation during atherosclerosis can be modulated by autoimmune against self-antigens, according to changeable risk factors (cholesterol, oxidized low-density lipoprotein (ox-LDL) wall, fatty acids, etc.), accompanied accumulation leucocytes proinflammatory cytokines, which stimulate...

Perforin (P) is a prototypical cytotoxic molecule involved in cell-mediated immunity against various pathogens, alloantigens and particularly different tumours. The purpose of this study was to determine P expression lymphocyte subpopulations isolated from peripheral blood prostate tissue patients with benign prostatic hyperplasia (BPH) cancer (PCa) compare it the found control group. Twenty subjects were recruited each groups. Prostate mononuclear cells BPH PCa tissues by enzymatic...

Tissue disintegration after injury leads, in the endoplasmic reticulum (ER), to activation of adaptive pathways known as ER stress response. It is directed correction unfolded proteins and proteasome-dependent ER-associated degradation misfolded proteins, but induces also a rapid natural immunity, since resident heat shock protein-gp96 acts not only molecular chaperone, strong adjuvant, able cross-present antigenic peptides onto MHC class I or II pathways. Analyzing its potential role...

Environmental airborne pollution has been repeatedly shown to affect multiple aspects of brain and cardiopulmonary function, leading cognitive behavioral changes the pronounced inflammatory response in respiratory airways. Since cellular defense system important role might have stress proteins-metallothionein (MT)-I MT-II, which are involved sequestration dispersal metal ions, regulation biosynthesis activities zinc-dependent transcription factors, as well protection from reactive oxygen...

The severe remodeling of endometrial stroma during blastocyst adhesion and trophoblast invasion initiates at maternal-fetal interface the reaction evolutionary old heat shock response, in which proteins, as molecular chaperons, monitor configurations newly synthesized proteins prevent formation functionless aggregates misfolded targeting them to degradation by a ubiquitin-proteasome system. In addition, endoplasmic reticulum (ER)-resident HSPs, such gp96/GRP94 may, after binding CD91 TLRs,...

Perforin-(P-) related characteristics of cytotoxic T lymphocytes and natural killer cells were investigated in peripheral blood patients subjected to open (OC;<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>23</mml:mn></mml:mrow></mml:math>) or laparoscopic cholecystectomy (LC;<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>21</mml:mn></mml:mrow></mml:math>) healthy...

Abstract Conditions such as stress, infection, autoimmune disease, etc. elevate the number and function of extrathymic T cells that are generated mainly in liver. As primitive, self‐reactive clones coexpress receptors natural killer (NK) lineage, they mediate cytotoxicity against altered self, malignant infected have unique potential to rapidly secrete large amount helper 1 (Th1) or Th2 cytokines. To elucidate whether some these changes occur even during syngeneic pregnancy, we made...