A5068232561- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Photoacoustic and Ultrasonic Imaging
- Various Chemistry Research Topics
- Thermography and Photoacoustic Techniques
- Immunotherapy and Immune Responses
- Porphyrin and Phthalocyanine Chemistry
- Spectroscopy and Laser Applications
- Social Media in Health Education
- Educational Strategies and Epistemologies
- Ultrasound and Hyperthermia Applications
- Cancer, Hypoxia, and Metabolism
- Climate Change Communication and Perception
- Healthcare Regulation
- Science Education and Pedagogy
- Chemistry and Chemical Engineering
- Porphyrin Metabolism and Disorders
- Conferences and Exhibitions Management
- Chemical Safety and Risk Management
- Science and Education Research
University of Coimbra
2020-2024
LaserLeap Technologies (Portugal)
2023-2024
Abstract Photodynamic therapy (PDT) with redaporfin stimulates colon carcinoma (CT26), breast (4T1) and melanoma (B16F10) cells to display high levels of CD80 molecules on their surfaces. overexpression amplifies immunogenicity because it increases same cell ( cis ) CD80:PD-L1 interactions, which (i) disrupt binding T-cells PD-1 inhibitory receptors ligands (PD-L1) in tumour cells, (ii) inhibit CTLA-4 cells. In some cancer redaporfin-PDT also PD-L1 expressions virtuous combinations between...
Predicting the extent of necrosis in photodynamic therapy (PDT) is critical to ensure that whole tumor treated but vital structures, such as major blood vessels vicinity tumor, are spared. The models developed for clinical planning rely on empirical parameters change with nature photosensitizer and target tissue. This work presents an vivo study livers rats due PDT a bacteriochlorin named redaporfin using both frontal illumination interstitial illumination. Various doses light at 750 nm were...
Molecular School (MS) is an extracurricular initiative intended to show relevant and complex concepts of chemical sciences precollege students. The main goal motivate the participants expand their awareness acknowledge its relevance in everyday life, order stimulate students engage chemistry undergraduate degrees. Here, we address successful case MS, implemented Portugal, where recently, universities have been facing significant difficulties attracting new join chemistry-related courses. We...
Nanodroplets' explosive vaporization triggered by absorption of laser pulses produces very large volume changes. These changes are two orders magnitude higher than those thermoelastic expansion generated equivalent pulses, and should generate correspondingly photoacoustic waves (PAW). The generation intense PAWs is desirable in tomography (PAT) to increase sensitivity. biocompatibility simplicity nanodroplets obtained sonication perfluoropentane (PFP) an aqueous solution bovine serum albumin...
Photodynamic therapy (PDT) remains an underutilized treatment modality in oncology. Many efforts have been dedicated to the development of better photosensitizers, formulations and delivery methods, rigorous planning light dose distribution tissues, mechanistic insight, improvement protocols combinations with other therapeutic agents. Hopefully, progress all these fields will eventually expand use PDT. Here we offer a brief review our own contribution photosensitizer for PDT - redaporfin...
Abstract Virtual events are flourishing with the world lockdown due to COVID‐19 pandemic. As a result of cancelation or postponement scheduled physical meetings, revolution in medicinal chemistry scientific meetings occurred, leading an increase new strategies share science. One example online events, namely e‐schools webinars. Taking this into consideration, we decided promote MedChemTrain e‐School 2020, virtual event aiming bring together community and some updates field. After organizing...
Abstract The planning, implementation and results of the first edition Molecular School are presented, as pre-university school project held in Portugal. This is not, however, a strictly Portuguese project, since it can be replicated other countries at secondary level, with minor adjustments. Herein, pilot detailed discussed, where 36 students have participated. plan for second edition, to semester 2021, confirmed participation around 100 students, further presented. Briefly, divided two...
We exposed aggressive 4T1 tumors to photoacoustic waves with the aim increase concentration of a photosensitizer in and improve outcome photodynamic therapy (PDT). The were generated using material that efficiently converts laser pulses into high-amplitude ultrasound pulses, their effect tumor priming assessed tomography. After redaporfin injection waves, treated light, leading significant survival mice compared untreated. These results suggest can efficacy PDT, may be promising strategy for...
Redaporfin is a photosensitizer under clinical trials for head and neck cancer. In previous work, continuous light source was used in several tumor models, either vitro or vivo. However, the use of pulsed (PL) sources can bring advantages to photodynamic therapy, such as higher penetration depths. To study influence efficacy redaporfin-PDT, balb/c mice were inoculated with subcutaneous CT26 tumors. activated using PL at 750 nm, repetition rate 20 Hz an energy per pulse 24 mJ/cm2....
Abstract Photodynamic therapy (PDT) with redaporfin stimulates colon carcinoma (CT26), breast (4T1) and melanoma (B16F10) cells to display high levels of CD80 molecules on their surfaces. overexpression amplifies immunogenicity because it increases same cell ( cis ) CD80:PD-L1 interactions, which (i) disrupt binding T-cells PD-1 inhibitory receptors ligands (PD-L1) in tumour cells, (ii) inhibit CTLA-4 cells. In some cancer redaporfin-PDT also PD-L1 expressions virtuous combinations between...
Homogeneous drug delivery to solid tumors is difficult achieve because of biological barriers in the tumor and its elevated interstitial fluid pressure. We investigated distribution a photosensitizer (redaporfin) orthotopic 4T1 subcutaneous CT26 using photoacoustic tomography. Redaporfin has distinct spectrum that allows for localization relative quantification. Whereas uptake large amount redaporfin, have redaporfin mostly their periphery. exposed high-intensity, broadband waves show...