A5030319136- Renal Transplantation Outcomes and Treatments
- Cytomegalovirus and herpesvirus research
- Renal Diseases and Glomerulopathies
- Renal and Vascular Pathologies
- Climate Change and Health Impacts
- Global Health Care Issues
- Monoclonal and Polyclonal Antibodies Research
- Organ Transplantation Techniques and Outcomes
- Blood groups and transfusion
- CAR-T cell therapy research
- Hepatitis Viruses Studies and Epidemiology
- Herpesvirus Infections and Treatments
- Organ and Tissue Transplantation Research
- Immunodeficiency and Autoimmune Disorders
- Hematopoietic Stem Cell Transplantation
- Immune cells in cancer
- Diabetic Foot Ulcer Assessment and Management
- Sodium Intake and Health
- Renal cell carcinoma treatment
- Health, Medicine and Society
- Thermoregulation and physiological responses
- Xenotransplantation and immune response
- Biomedical Ethics and Regulation
- Atherosclerosis and Cardiovascular Diseases
- Neonatal Health and Biochemistry
University Hospital of Zurich
2022-2025
Kantonsspital Winterthur
2021
Medical University of Graz
2014-2015
Ospedale Regionale di Locarno
2015
Background. Biopsy-based transcripts associated with antibody-mediated rejection (AMR) hold promise as substitutes for C4d positivity. However, their utility in cases additional diagnoses other than remains inadequately studied. Methods. In our comprehensive analysis of 326 kidney allograft biopsies, assessed by histology and the Molecular Microscope Diagnostic System, we identified 68 characterized pathologies, including pyelonephritis (n = 15), BK nephropathy 20), acute interstitial...
Isolated Tubulitis, Borderline Changes, and Arteritis suspicious for histologic T cell-mediated rejection (hTCMR) remain findings of uncertain significance. Although the Molecular Microscope Diagnostics System (MMDx) has not been trained on those lesions, it was suggested that MMDx might reclassify a subgroup to molecular TCMR (mTCMR).
The health-care system and particularly renal replacement therapy has a significant carbon footprint adding to global warming extreme weather conditions. Improving sustainability become the focus of national international working groups. Many reviews underline need for improvement in nephrology, particular dialysis, provide recommendations on how reduce waste, energy, water consumption. However, implement these recommendations, where start, is not always clear. This paper summarizes...
Green nephrology, also often called sustainable has become a field of interest in our discipline recent years. While several reviews have been published, comparatively few original papers appeared, witnessing but lack data. Greater awareness the impact nephrology on planet, including, not limited to its carbon footprint, is needed promote education and research these issues. Increasing entails increasing knowledge at various levels it for this reason that we are presenting review focusing...
Letermovir (LTV) might be an alternative treatment to nephrotoxic foscarnet (FOS) in Ganciclovir (GCV) resistant cytomegalovirus (CMV) infection. However, its efficacy controlling active CMV viremia is unclear, as it only approved for prophylaxis hematopoietic stem-cell transplantation.This case series describes 14 kidney transplant recipients (KTR) with moderate-level GCV infection, treated by different step-down strategies after initial FOS therapy: (1) Observation without antiviral...
Abstract Background Before the availability of mRNA vaccines, many transplant centers chose to significantly reduce maintenance immunosuppression in kidney recipients (KTRs) with SARS‐CoV‐2 infection. The extent which this increases risk allosensitization is unclear. Methods In observational cohort study, we analyzed 47 KTRs from March 2020 February 2021 who underwent substantial reduction during were followed at 6 and 18 months concerning development de novo donor‐specific anti‐HLA (human...
Background The spleen has been implicated in the pathogenesis of immune-complex glomerulonephritis by initiating and resolving adaptive immune responses. Thus, we aimed to evaluate role experimental nephrotoxic serum nephritis (NTS). Methods In order accelerate disease, animals were subjected NTS preimmunizing male C57BL/6J mice with rabbit IgG three days before injecting anti-glomerular basement antiserum, or immunized only. A group underwent splenectomy induction. Results We observed...
Immune-responsiveness to SARS-CoV-2 mRNA vaccination is reduced in kidney transplant recipients (KTRs). Previous reports point a role of mycophenolic acid (MPA). Our observational cohort study included all KTRs at University Hospital Zurich receiving two vaccine doses more than 6 months post-transplantation, who were assessed by measuring anti-spike immunoglobulin G (IgG). We applied principles therapeutic drug monitoring (TDM) correlate MPA exposure and lymphocyte counts with IgG. trough...
Abstract Background and Aims Biopsy based transcript diagnostics using the molecular microscope diagnostic system (MMDx) have potential to add clarification in antibody mediated rejection (AMR) continuum. While de novo donor specific (dnDSA) or preformed DSA accompanied by allograft function deterioration are accepted indications for biopsy with therapeutic implications, management strategy subclinical lacks consensus. MMDx might show clinical utility this controverse scenario helping...
Abstract Background and Aims Biopsy-based transcripts associated with antibody-mediated rejection (AMR) hold promise as substitutes for C4d positivity, according to the latest Banff Meeting Report of 2022. However, patterns strength phenotype scores remain inadequately studied within new subgroups along AMR continuum. Method We analyzed 365 kidney allograft biopsies by histology Molecular Microscope Diagnostic System (MMDx) at University Hospital Zurich from July 2021 November 2023....
Abstract Background and Aims Previous studies have shown substantial heterogeneity in the performance of estimated glomerular filtration rate (eGFR) equations when applied to kidney transplant recipients (KTRs). The impact transplantation-related characteristics on eGFR based creatinine (eGFRcr) compared with cystatin C (eGFRcr-cys), however, remains insufficiently studied. Method We analyzed 596 KTRs transplanted at University Hospital Zurich. accuracies four eGFRcr (CKD-EPI 2009 2021, EKFC...
Abstract Background and Aims The prevalence of cardiorenal syndrome is increasing due to the growing number patients with chronic kidney disease (CKD) heart failure (HF). To further improve outcomes in this high risk population, an interdisciplinary, evidence-based patient-centered approach advocated. Hence, it was aim study identify describe patient population which might profit from inter- multidisciplinary nephrology cardiology clinic at a tertiary university hospital. Method We screened...
Abstract Background and Aims Biopsy-based transcripts associated with antibody-mediated rejection (AMR) hold promise as substitutes for C4d positivity, according to the Banff Meeting Report of 2022. However, incorporating histologic molecular features disease activity chronicity is crucial potentially guide patient management. Method We analyzed 365 kidney allograft biopsies by histology Molecular Microscope Diagnostic System (MMDx) at University Hospital Zurich from July 2021 November 2023....
Abstract Background and Aims While trough level (TL) guided dosing is usus for calcineurin inhibitors, mycophenolic acid (MPA) was marketed as a one-size-fits-all drug. TL has been reported to be poor surrogate marker of MPA exposure by reason complex pharmacokinetics. Measurement area under the curve (AUC) remains gold-standard dosing. Method We measured AUC in 299 KTRs at University Hospital Zurich. with agreement between target range 40-60 mg/Lxh were compared missing differences...
2 and 3 were observed in 43%, 47% 10% of these specimens. Leucocyte subpopulations categorized focal vs. diffuse monocytic (11%/24%), granulocytic (4%/4%), or mixed (14%/20%). In 23% the cases ptc was not classified (e.g. vicinity tubular necrosis, pyelonephritis infarct). Ptc scores (1, 3) associated with both diagnosis AMR cellular rejection (ACR). Diffuse (OR=4.51, 95% CI 1.82-11.16, OR=6.8, 2.44-19.36, p≤0.001), but (OR=3.81, 0.41-35.02, p=0.2) AMR. At same time, ACR, regardless its...
Abstract Background and Aims Mycophenolate acid (MPA) is a standard component of maintenance immunosuppression after kidney transplantation. MPA, however, increases the risk leucopenia. In past, mTOR inhibitors (mTOR-I) in combination with calcineurin (CNI), were considered immunologically safe but showed higher mortality long term. Method We conducted retrospective single-center study analyzing 98 transplant recipients (KTRs) under triple between 2020 2022 who developed compared patient...