A5015826586- Amino Acid Enzymes and Metabolism
- Respiratory viral infections research
- Influenza Virus Research Studies
- DNA Repair Mechanisms
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- HIV Research and Treatment
- Glioma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Adenosine and Purinergic Signaling
- Epigenetics and DNA Methylation
- Chronic Myeloid Leukemia Treatments
- SARS-CoV-2 and COVID-19 Research
- Colorectal Cancer Treatments and Studies
- DNA and Nucleic Acid Chemistry
- Neurogenesis and neuroplasticity mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- Acute Lymphoblastic Leukemia research
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Cancer therapeutics and mechanisms
- Cancer-related Molecular Pathways
- HIV-related health complications and treatments
- T-cell and B-cell Immunology
- Biochemical and Molecular Research
VIR Biotechnology (United States)
2024
University of Washington
2010-2017
University of Washington Medical Center
2010
Influenza A results in significant morbidity and mortality. VIR-2482, an engineered human monoclonal antibody with extended half-life, targets a highly conserved epitope on the stem region of influenza hemagglutinin may protect against seasonal pandemic influenza.
ABSTRACT The objective of this study was to evaluate the safety, tolerability, pharmacokinetics (PK), and immunogenicity VIR-2482 in healthy adult subjects. A phase 1, first-in-human, randomized, double-blind, placebo-controlled dose-escalation conducted. One hundred participants were allocated four cohorts (60 mg, 300 1,200 1,800 mg). In each cohort, randomized a 4:1 ratio (active:placebo) receive either or volume-matched placebo by gluteal intramuscular injection. Participants remained at...
The basis for the use of nucleoside tracers in PET is that activity cell-growth–dependent enzyme thymidine kinase 1 rate-limiting factor driving tracer retention tumors. Recent publications suggest transporters might influence uptake and thereby affect signal vivo. Understanding transport mechanisms different important evaluating clinical results. This study examined relative role [methyl-<sup>3</sup>H]-3′-deoxy-3′-fluorothymidine (<sup>3</sup>H-FLT), [methyl-<sup>3</sup>H]-thymidine...
Abstract Background Influenza A results in significant morbidity and mortality. VIR-2482, an engineered human monoclonal antibody with extended half-life, targets a highly conserved epitope on the stem region of influenza hemagglutinin, may protect against seasonal pandemic influenza. Methods This double-blind, randomized, placebo-controlled, phase 2 study examined safety efficacy VIR-2482 for illness prevention unvaccinated healthy adults. Participants (N = 2977) were randomized 1:1:1 to...
Increasing age is the most robust predictor of greater malignancy and treatment resistance in human gliomas. However, adverse association clinical course with aging rarely considered animal glioma models, impeding delineation relative importance organismal versus progenitor cell genesis malignancy. To address this limitation, we implanted transformed neural stem/progenitor cells (NSPCs), presumed origin, from 3- 18-month-old mice into 20-month host animals. Transplantation progenitors older...
Abstract Both the G2 chromosomal radiosensitivity assay and allelic differences in TP53 codon‐72 have been associated with cancer predisposition. The relationship between two endpoints was determined 56 human EBV‐transformed lymphoblastoid cell lines. Although there were overlapping distributions of sensitivity for different genotypes, lines that homozygous proline coding allele more likely to be resistant chromatid break formation than those containing arginine alleles, whereas expressing...
Gut-homing α4β7high CD4+ T lymphocytes have been shown to be preferentially targeted by human immunodeficiency virus type 1 (HIV-1) and are implicated in HIV-1 pathogenesis. Previous studies demonstrated that envelope protein gp120 binds signals through α4β7 this likely contributes the infection of cells promotes cell-to-cell transmission. Structures within second variable loop (V2) gp120, including tripeptide motif LDV/I, thought mediate gp120-α4β7 binding. However, lack binding has...