A5033002641- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Plant Pathogens and Fungal Diseases
- Insect Pest Control Strategies
- Plant-Microbe Interactions and Immunity
- Aluminum toxicity and tolerance in plants and animals
- Coffee research and impacts
- Plant Stress Responses and Tolerance
- Fungal Biology and Applications
- Research on Leishmaniasis Studies
- Insect Resistance and Genetics
- Chemical synthesis and alkaloids
- Heavy Metals in Plants
- Microbial Metabolism and Applications
- bioluminescence and chemiluminescence research
- Bamboo properties and applications
- Mycorrhizal Fungi and Plant Interactions
- Genomics and Phylogenetic Studies
- Synthesis and Biological Activity
- Aquatic Ecosystems and Phytoplankton Dynamics
- Synthesis and Catalytic Reactions
- Essential Oils and Antimicrobial Activity
- Algal biology and biofuel production
- Synthesis and biological activity
- Synthetic Organic Chemistry Methods
Universidade de São Paulo
2014-2024
Departamento de Ciência e Tecnologia
2014-2023
Sociedade Brasileira de Química
2023
Universidade Estadual Paulista (Unesp)
2020
Forest Science and Research Institute
2020
Ashland (United States)
2018
Hospital Universitário da Universidade de São Paulo
2018
Universidade Federal do Oeste da Bahia
2016
Secretaria de Agricultura e Abastecimento
2014
Universidade Federal de São Carlos
2006-2010
Anthracnose is a crop disease usually caused by fungi in the genus Colletotrichum or Gloeosporium. These are considered one of main pathogens, causing significant economic losses, such as peppers and guarana. The current forms control include use resistant cultivars, sanitary pruning fungicides. However, even with some methods controlling these cultures, crops not free anthracnose. Additionally, excessive application fungicides increases resistance pathogens to agrochemicals cause harm human...
The rising frequency of extreme climate events requires sustainable strategies to secure food production. Environmental stress impacts seed germination and seedling development, posing a significant agricultural challenge. To address this, we developed applied iron-based nanoparticles (Bio-NPs) synthesized through green biosynthesis from Haematococcus pluvialis, microalga rich in antioxidants like astaxanthin. These Bio-NPs, approximately 21 nm diameter characterized by negative surface...
Two coumarin derivatives, esculetin-4-carboxylic acid methyl ester (1) and ethyl (2), have been isolated from the marine sponge Axinella cf. corrugata. Structure determination included analysis of spectroscopic data total synthesis compound 2. These are first derivatives a sponge. The 2 was found to be an in vitro inhibitor SARS 3CL-protease effective SARS-CoV replication Vero cells at non-cytotoxic concentrations.
Three new disulfated meroterpenoids, ilhabelanol (1), ilhabrene (2), and isoakaterpin (3), have been isolated from extracts of the Brazilian marine sponge Callyspongia sp. Isoakaterpin (3) inhibits Leishmania spp. adenosine phosphoribosyl transferase with an IC50 1.05 μM. The structures 1, 2, 3 were elucidated by analysis one- two-dimensional NMR data. Ilhabelanol (1) (2) both unprecedented meroterpenoid carbon skeletons.
Herein we present the results of a screening with 349 crude extracts Brazilian marine sponges, ascidians, bryozoans and octocorals, against 16 strains susceptible antibiotic-resistant bacteria, one yeast (Candida albicans), Mycobacterium tuberculosis H37Rv, three cancer cell lines MCF-7 (breast), B16 (murine melanoma ) HCT8 (colon), Leishmania tarentolae adenine phosphoribosyl transferase (L-APRT) enzyme. Less than 15% sponge displayed antibacterial activity, both bacteria. Up to 40%...
Extracts obtained from 57 marine-derived fungal strains were analyzed by HPLC-PDA, TLC and ¹H NMR. The analyses showed that the growth conditions affected chemical profile of crude extracts. Furthermore, majority which produced either bioactive chemically distinctive extracts have been isolated sediments or marine algae. investigation antimycobacterial cytotoxic extract two fungus Beauveria felina yielded cyclodepsipeptides related to destruxins. present approach constitutes a valuable tool...
The structure of the fungal metabolite roussoellatide (1) has been established by spectroscopic and X-ray diffraction analyses. Results from feeding experiments with [1-13C]acetate, [2-13C]acetate, [1,2-13C]acetate were consistent a biosynthetic pathway to unprecedented skeleton 1 involving Favorskii rearrangements in separate pentaketides, subsequently joined via an intermolecular Diels–Alder reaction.
ASCIDIAN Didemnum ligulum AND FROM THE OCTOCORAL Carijoa riisei.The investigation of extracts from six species marine invertebrates yielded one new and several known natural products.Isoptilocaulin the sponge Monanchora aff.arbuscula displayed antimicrobial activity at 1.3 μg/mL against an oxacillin-resistant strain Staphylococcus aureus.Five inactive dibromotyrosine derivatives, 2 -6, were isolated a sponge, Aplysina sp.The sponges Petromica ciocalyptoides Topsentia ophiraphidites...
The chemical investigation of the crude extract an ascidian genus Didemnumled to isolation modified diketopiperazine rodriguesines A (1) and (2) as a mixture homologues, which could be identified by analysis spectroscopic data including MS/MS experiments. second Didemnumsp. led N-acetyl-rodriguesine (3) B (4). absolute configuration compounds 1and 2could established hydrolysis Marfey's comparison with literature reported for compound 3, previously obtained synthetic product. 2displayed...
In the present investigation we report antibacterial activity of halistanol sulfate A isolated from sponge Petromica ciocalyptoides, as well rodriguesines and B ascidian Didemnum sp., against caries etiologic agent Streptococcus mutans. The transcription levels S. mutans virulence genes gtfB, gtfC gbpB, housekeeping groEL 16S, were evaluated by sqRT-PCR analysis planktonic cells. There no alterations in expression 16S after antimicrobial treatment with B, but gbpB was down-regulated....
A new method of screening was developed to generate 770 organic and water-soluble fractions from extracts nine species marine sponges, the growth media 18 marine-derived fungi, 13 endophytic fungi. The results indicated that displayed significant bioactivity in cytotoxic, antibiotic, anti-Leishmania, anti-Trypanosoma cruzi, inhibition proteasome assays. Purification medium Penicillium solitum IS1-A provided glutamic acid derivatives solitumine (1), B (2), solitumidines A–D (3–6). structures...
Bioassay-guided investigation of the EtOAc-soluble extract a culture marine-derived fungus Peroneutypa sp. M16 led to isolation seven new polyketide- and terpenoid-derived metabolites (1, 2, 4–8), along with known polyketides (3, 9–13). Structures compounds 1, 4–8 were established by analysis spectroscopic data. Absolute configurations 4, 6, 7, 8 determined comparison experimental ECD spectra calculated CD Compound 5 exhibited moderate antiplasmodial activity against both...
In order to investigate the chemical profile of 14 specimens Aplysina spp. marine sponges, we have developed a method based on LC-PDA-MS for detection bromotyrosine-derived metabolites. The enabled dereplication three distinct chemotypes compounds UV absorptions, which were further refined by electrospray ionization-mass spectrometry analysis brominated quasi-molecular ion clusters. This procedure led either single compound assignment, or maximum two possible isobaric compounds. study...
Coffee is one of the most consumed beverages in world. Its chemical composition may have varied according to planting site, degree roasting, and method preparation. This work aimed evaluate antioxidant activity coffee from region Cerrado State Minas Gerais, Brazil. The evaluation was performed with samples roasted at two different levels (traditional extra dark) using preparation methods (decoction infusion) that reflect conditions preparing coffee. In vitro by ABTS DPPH radical...
Fungi are present in the most diverse environments including interior of plant tissues, living as endophytes without causing apparent damage. These producers secondary metabolites, also known natural products, such fungicides. Here, we evaluated ethyl acetate fractions obtained from endophytic fungi isolated plants genus Begonia. The were submitted to inhibitory test against pathogens Diaporthe phaseolorum and Colletotrichum gloeosporioides. From 88 evaluated, 14.7 % inhibited C....
Destruxins (Dtx) are cyclodepsipeptides produced by enthomopathogenic fungi, which used in biological control of different agricultural insect plagues. The present investigation reports a new approach for analysis destruxins the fungal strain Beauveria felina, using LC-PDA-ELSD-MS. Compared to previous methods, uses clean-up on C18 cartridges, effectively removes growth media constituents. Moreover, use 50:50 (v/v) MeCN/MeOH as strongest eluting solvent gradient system over 0.1% H2O proved...
ABSTRACT Charcoal is a widely used product for barbecue, however, its quality said use has not been well studied. Polycyclic aromatic hydrocarbons (PAHs) are class of carcinogenic compounds that can be present in charcoal. Thus, the objective this study was to analyze organic phase extracted from charcoal by solvents, regarding presence PAHs. For this, commercial brand acquired, collected establishments city Piracicaba, São Paulo. Complementary tests were carried out identify wood production...