A5077660936- Intraperitoneal and Appendiceal Malignancies
- Appendicitis Diagnosis and Management
- Colorectal Cancer Surgical Treatments
- Ovarian cancer diagnosis and treatment
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Hernia repair and management
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Intestinal and Peritoneal Adhesions
- BRCA gene mutations in cancer
- Thyroid Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Cancer Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Breast Cancer Treatment Studies
- Cardiac, Anesthesia and Surgical Outcomes
- CAR-T cell therapy research
- Global Cancer Incidence and Screening
- Immunotherapy and Immune Responses
- Thyroid and Parathyroid Surgery
Sheba Medical Center
2016-2025
Rebecca Sieff Hospital
2024-2025
Bar-Ilan University
2025
Tel Aviv University
2016-2024
Boston University
2023
Truven Health Analytics (United States)
2023
IDEX Corporation (United States)
2023
Israel Cancer Association
2022
Hebrew University of Jerusalem
1996-2021
University of Southern California
2019
Bacteria were first detected in human tumors more than 100 years ago, but the characterization of tumor microbiome has remained challenging because its low biomass. We undertook a comprehensive analysis microbiome, studying 1526 and their adjacent normal tissues across seven cancer types, including breast, lung, ovary, pancreas, melanoma, bone, brain tumors. found that each type distinct composition breast particularly rich diverse microbiome. The intratumor bacteria are mostly intracellular...
Ipilimumab, a fully human monoclonal antibody that blocks cytotoxic T-lymphocyte antigen-4, has demonstrated an improvement in overall survival two phase III trials of patients with advanced melanoma. The primary objective the current trial was to prospectively explore candidate biomarkers from tumor microenvironment for associations clinical response ipilimumab.
Fusobacterium nucleatum is an oral anaerobe recently found to be prevalent in human colorectal cancer (CRC) where it associated with poor treatment outcome. In mice, hematogenous F. can colonize CRC tissue using its lectin Fap2, which attaches tumor-displayed Gal-GalNAc. Here, we show that Gal-GalNAc levels increase as breast progresses, and occurrence of gDNA samples correlates high levels. We demonstrate Fap2-dependent binding the bacterium samples, inhibited by GalNAc. Intravascularly...
Abstract Early detection of colorectal cancer (CRC) is currently based on fecal occult blood testing (FOBT) and colonoscopy, both which can significantly reduce CRC‐related mortality. However, FOBT has low‐sensitivity specificity, whereas colonoscopy labor‐ cost‐intensive. Therefore, the discovery novel biomarkers that be used for improved CRC screening, diagnosis, staging as targets therapies utmost importance. To identify we utilized representational difference analysis (RDA) characterized...
Local regional recurrence (LRR) remains the primary cause of treatment failure in solid tumors despite advancements cancer therapies. Canady Helios Cold Plasma (CHCP) is a novel Atmospheric device that generates an Electromagnetic Field and Reactive Oxygen Nitrogen Species to induce cell death. In first FDA-approved Phase I trial (March 2020-April 2021), 20 patients with stage IV or recurrent underwent surgical resection combined intra-operative CHCP treatment. Safety was endpoint; secondary...
Objective To analyze voice function before and after thyroidectomy for patients with normal preoperative using a standardized multidimensional assessment protocol. Summary Background Data The natural history of post-thyroidectomy disturbances preserved laryngeal nerve has not been systematically studied characterized the intent data postoperative rehabilitation. Methods During prospective single-arm study, underwent functional testing grading scale battery acoustic, aerodynamic,...
To define multimolecular phenotypes of adrenocortical carcinoma (ACC) and to correlate outcome with morphologic molecular parameters.Clinical data were analyzed for 124 patients, histopathologic slides 67 primary tumors, tissue specimens 74 patients (38 36 metastatic tumors) ACC 38 normal adrenal samples. Molecular expression profiles investigated by immunohistochemistry. The prognostic significance 12 gross histologic parameters in ACCs was evaluated. Morphologic protein patterns correlated...
Abstract Background Evaluation of peritoneal metastases by computed tomography (CT) scans is challenging and has been reported to be inaccurate. Methods A multi‐institutional prospective observational registry study patients with carcinomatosis from colorectal cancer was conducted a subset analysis performed examine index (PCI) based on CT intraoperative exploration. Results Fifty‐two (mean age 52.6 ± 12.4 years) 16 institutions were included in this study. Inaccuracies CT‐based assessment...
It is a commonly held belief that infiltration of immune cells into tumor tissues and direct physical contact between infiltrated associated with destructions the cells, reduction burden, improved clinical prognosis.An increasing number studies, however, have suggested aberrant or normal may promote progression, invasion, metastasis.Neither primary reason for these contradictory observations, nor mechanism reported diverse impact tumor-infiltrating has been elucidated, making it difficult to...
Abstract Introduction Systemic therapy and cytoreduction (CRS) with hyperthermic intra‐peritoneal chemotherapy (HIPEC) may benefit selected patients carcinomatosis from colon cancer (PC). This study presents the results of a consecutive series evaluated under single strategy. Patients Methods Forty PC referred for CRS were evaluated. Evaluation their treatment was determined according to disease severity scored on 3‐point scale including: (1) symptoms, (2) extent peritoneal dissemination...
The need for improved specificity in the local treatment of inflammatory bowel diseases (IBD) led us to use negatively charged liposomes target inflamed colonic epithelium. purpose present study was elucidate cause our previous observations that such accumulate, preferentially, mucosa rats were induced with experimental colitis, following luminal administration. Protein analysis (tandem mass spectrometry, verified by Western blot) mucosal specimens, extracted at pH 3, 5 and 7, revealed an...
Abstract Background The transition from normal epithelium to adenoma and, invasive carcinoma in the human colon is associated with acquired molecular events taking 5-10 years for malignant transformation. We discovered CCAT1, a non-coding RNA over-expressed cancer (CC), but not tissues, thereby making it potential disease-specific biomarker. aimed define and validate CCAT1 as CC-specific biomarker, study expression across adenoma-carcinoma sequence of CC tumorigenesis. Methods Tissue samples...
// Inbar Levi 1, * , Hagai Amsalem 2, Aviram Nissan 3 Merav Darash-Yahana 4 Tamar Peretz Ofer Mandelboim 5 Jacob Rachmilewitz 1 Goldyne Savad Institute of Gene Therapy, Hadassah-Hebrew University Medical Center, Jerusalem, Israel 2 Department Obstetrics and Gynecology, Hadassah Hospital-Mount Scopus, The Surgical Oncology Laboratory, Surgery, Mount Sharett Oncology, Lautenberg Center for General Tumor Immunology, Research Israel-Canada, Hebrew University-Hadassah School, These authors have...
Abstract The aim of the present study was to evaluate toxicity biodegradable hydrogels in rat with a future utilizing this hydrogel as vehicle for brachytherapy delivery cancer patients. Two types chitosan hydrogels: fast degrading and slow degrading; were prepared surgically implanted rats. adjacent tissue response gels after subcutaneous intraperitoneal implantation examined histologically found be identical typical foreign body milder than absorbable surgical sutures (Vicril®). Neither...
Background: Although thyroid nodules are common and diagnosed in over 5% of the adult population, only harbor malignancy. Patients with clinically suspicious need to undergo fine-needle aspiration biopsy (FNAB). The main limitation FNAB remains indeterminate cytopathology. Only 20%–30% malignancy, therefore up 80% patients unnecessary thyroidectomy. aim this study was identify validate a panel microRNAs (miRNAs) that could serve as platform for an FNAB-based diagnostic neoplasms. Methods:...