Aim We aim to describe the pattern of response treatment in a cohort Egyptian lupus nephritis (LN) patients and define variable prognostic factors. Methods retrospectively analyzed records 928 systemic erythematosus (SLE) (898 females, 30 males) with biopsy-confirmed LN seen between 2006 2012 at Cairo University hospitals. Results Our study involved SLE mean age 26.25 ± 6.487 years, duration time renal biopsy 6.48 4.27 months, SLEDAI 28.22 11.7, follow-up 44.14 17.34 months. Induction...

Objective: We hypothesised that vitamin D has a beneficial renal protective effect from diabetic nephropathy (DN).Methods: Four rat groups were included: normal control (control), type 2 diabetes for eight weeks (DM), treated group with angiotensin receptor blocker losartan (DM + L), and D-treated started the onset of Vit D).Results: In both groups, we found significant (p < .05) reduction in pro-inflammatory profibrotic markers induced by diabetes. Vitamin caused more monocyte...

&lt;b&gt;&lt;i&gt;Introduction:&lt;/i&gt;&lt;/b&gt; The side effects profile of the new direct-­acting antivirals for treatment hepatitis C virus (HCV) is not fully elucidated. &lt;b&gt;&lt;i&gt;Objective:&lt;/i&gt;&lt;/b&gt; In this cross-sectional study, we aim to describe incidence and characteristics a novel observation de novo renal cryoglobulinemic glomerulonephritis after successful with DAA. &lt;b&gt;&lt;i&gt;Methodology:&lt;/i&gt;&lt;/b&gt; A total 12,985 Hepatitis Patients...

Despite that cyclosporine-A (CsA) is a widely used immunosuppressive drug, its nephrotoxic effect limits long-term administration. Herein we tried to investigate renal on endothelial dysfunction targeting the hypoxia-inducible factor (HIF-1α) / vascular growth (VEGF) nitric oxide synthase (eNOS) pathway and possible modulation by nicorandil. Eight groups of adult male Wistar rats were included: (1) control; (2) vehicle group (received oil); (3) glibenclamide 5 mg·kg –1 ·day administered...

Purpose: To histopathologically compare the effect of different orientations cryopreserved human amniotic membrane (AM) transplant during extraocular muscle surgery in rabbits.Methods: Fifty-two albino rabbit eyes underwent 4-mm resection superior rectus. Eyes were randomly divided into four groups. In Group C (Control group, 16 eyes) was not wrapped with membrane. three AM groups, around muscle, oriented either its stroma (Group S, 15 or epithelium E, nine towards folded on itself...

The chronic dysfunction stands as the most common cause of renal allograft loss. During nineties past century, this condition was referred to nephropathy (CAN). Since 2005, CAN has been assigned by eighth Banff schema four main categories via histopathological and immunohistochemical findings including antibodymediated rejection (CAMR), T-cell-mediated (CTMR), cyclosporine toxicity (CNITOX), "interstitial fibrosis (IF)/tubular atrophy; not otherwise specified (NOS)" eliminate term CAN. We...

The impact of hepatitis virus infection on arterial calcification (AC) was not studied.To study the prevalence, severity and distribution AC in incident hemodialysis patients with B C viral infection.172 stage 5 CKD adults (98 male 74 female) were included; 58 them seronegative for both (SN group), 48 positive (HBV group) 66 (HCV group). Beside histopathology obtained samples, all these cases examined body mass index (BMI), serum calcium (Ca), phosphorus (P), alkaline phosphatase (AP),...

The impact of hepatitis virus infection on arterial calcification (AC) was not studied. To study the prevalence, severity and distribution AC in incident hemodialysis patients with B C viral infection. 172 stage 5 CKD adults (98 male 74 female) were included; 58 them seronegative for both (SN group), 48 positive (HBV group) 66 (HCV group). Beside histopathology obtained samples, all these cases examined body mass index (BMI), serum calcium (Ca), phosphorus (P), alkaline phosphatase (AP),...

Abstract Background Renal tubulointerstitial fibrosis is a structural marker and prominent pathological characteristic of chronic progressive kidney disease, fibroblast growth factor-2 (FGF2) key fibrogenic cytokine that likely to be involved in the pathogenesis renal fibrosis, injury molecule-1 (KIM-1) one most promising, early biomarkers either acute or chronic, due its translatability between preclinical clinical trials. It believed this molecule participates process both healing. Methods...

&lt;b&gt;&lt;i&gt;Introduction:&lt;/i&gt;&lt;/b&gt; Arterial calcification (AC) is a common complication in chronic kidney disease (CKD) patients that starts to develop before these need renal replacement therapy. In patients, can involve tunica intima or media. This study has looked for the prevalence, severity, and distribution of arterial wall incident hemodialysis through intraoperative biopsy obtained during creation arteriovenous vascular access hemodialysis....

Abstract Introduction Thrombotic microangiopathy (TMA) in needle renal biopsy stands as one of the most important diagnostic critical values nephropathology, and a challenge many affected patients. The condition has various etiologies with different underlying pathogenetic mechanisms. urgent handling such cases clinical anticipation histopathological diagnosis draws management prognosis these Objectives In this paper, characteristics native TMA lesions were analyzed determination possible...

Introduction: Medical renal diseases stand as one of the major health problems in pediatric age group considering its morbidity/mortality and subsequent management plans. Objectives: In this manuscript, spectrum histopathological patterns medical nephropathic lesions Egyptian patients over duration five years is reported with clinical indications. Patients Methods: We conducted a retrospective study for analysis our pathological reports needle biopsies during period from January 2014 until...