A5102856207- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Autism Spectrum Disorder Research
- Wnt/β-catenin signaling in development and cancer
- Transcranial Magnetic Stimulation Studies
- Nuclear Receptors and Signaling
- Advanced Memory and Neural Computing
- Cellular transport and secretion
- Sleep and Wakefulness Research
- Neurogenesis and neuroplasticity mechanisms
- Estrogen and related hormone effects
- Retinoids in leukemia and cellular processes
- EEG and Brain-Computer Interfaces
- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Ion channel regulation and function
- Photoreceptor and optogenetics research
- Macrophage Migration Inhibitory Factor
- Space Exploration and Technology
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
University of Maryland, Baltimore
2023
Hussman Institute for Autism
2016-2021
University of Pennsylvania
2012-2017
The formation of a long-lasting memory requires transcription-dependent consolidation period that converts short-term into long-term memory. Nuclear receptors compose class transcription factors regulate diverse biological processes, and several nuclear have been implicated in formation. Here, we examined the potential contribution to by measuring expression all 49 murine after learning. We identified 13 with increased learning, including 3 members Nr4a subfamily. These CREB-regulated genes...
Manned spaceflight poses significant physiological and psychological challenges, with microgravity, irradiation, confinement, social isolation contributing to stress-related health risks. Microgravity in particular causes cardiovascular, muscular, immune, cognitive changes, often accompanied by elevated glucocorticoid (GC) stress-hormone levels mediated the hypothalamic-pituitary-adrenal (HPA) axis. However, conflicting evidence exists regarding GC elevation, little is known about how...
Ischemic stroke (IS) significantly impacts long-term health and quality of life, due in part to stress-induced hyperactivation the hypothalamic-pituitary-adrenal (HPA) axis. Elevated corticosterone hypercortisolism after exacerbate neuronal injury delay recovery. However, dynamics stress-responsive activity following IS, how these changes contribute outcomes, remain understudied. We hypothesize that corticotropin-releasing factor (CRF)+ neurons hypothalamic paraventricular nucleus (PVN) GAD+...
Abstract GABA released from presynaptic sites induces short-lived phasic inhibition mediated by synaptic A receptors (GABA Rs) and longer-duration tonic extrasynaptic or B Rs). number of studies have found that contactin-associated protein 2 (Cntnap2) knockout (KO) mice, a well-established mouse model autism, exhibit reduced interneuron numbers aberrant inhibition. However, little is known about whether disrupted in Cntnap2 KO mice when the disruption begins to occur during postnatal...
Long-term memory depends on the control of activity-dependent neuronal gene expression, which is regulated by epigenetic modifications. The modification histones orchestrated opposing activities 2 classes regulatory complexes: permissive coactivators and silencing corepressors. Much work has focused coactivator complexes, but little known about corepressor complexes that suppress expression plasticity-related genes. Here, we define a critical role for SIN3A in synaptic plasticity, showing...
Abstract Trauma and chronic stress exposure are the strongest predictors of lifetime neuropsychiatric disease presentation. These disorders often have significant sex biases, with females having higher incidences affective such as major depression, anxiety, PTSD. Understanding mechanisms by which heightens vulnerability is essential for developing novel interventions. Current rodent models consist a battery sensory, homeostatic, psychological stressors that ultimately integrated...
Autism spectrum disorder (ASD) is a neurologic condition characterized by alterations in social interaction and communication, restricted and/or repetitive behaviors. The classical Type II cadherins cadherin-8 (Cdh8, CDH8) cadherin-11 (Cdh11, CDH11) have been implicated as autism risk gene candidates. To explore the role of etiology autism, we investigated their expression patterns during mouse brain development autism-specific human tissue. In mice, was developmentally regulated enriched...
Abstract Tomosyn, a protein encoded by syntaxin‐1‐binding 5 ( STXBP5 ) gene, has well‐established presynaptic role in the inhibition of neurotransmitter release and reduction synaptic transmission its canonical interaction with soluble N ‐ethylmaleimide‐sensitive factor attachment receptor machinery. However, postsynaptic tomosyn dendritic arborization, spine stability, trafficking ionotropic glutamate receptors remains to be elucidated. We used short hairpin RNA knock down mouse primary...
Parvalbumin-expressing fast-spiking interneurons (PV-INs) control network firing and the gain of cortical response to sensory stimulation. Crucial for these functions, PV-INs can sustain high-frequency with no accommodation. However, also exhibit short-term depression (STD) during sustained activation, largely due depletion synaptic resources (vesicles). In most synapses rate replenishment depleted vesicles is constant, determining an inverse relationship between levels activation rate,...
Abstract Autism spectrum disorder (ASD) is a neurological condition characterized by alterations in social interaction and communication, restricted and/or repetitive behaviors. The classical type II cadherins cadherin-8 (Cdh8, CDH8) cadherin-11 (Cdh11, CDH11) have been implicated as autism risk gene candidates. To explore the role of etiology autism, we investigated their expression patterns during mouse brain development autism-specific human tissue. In mice, was developmentally regulated...
Summary Fast-spiking parvalbumin positive interneurons (PV-INs) are essential for controlling network firing and the gain of cortical response to sensory stimulation. Crucial these functions, PV-INs can sustain high frequency with no accommodation. However, also exhibit short-term depression (STD) during sustained activation, which is largely due depletion synaptic resources (vesicles). In most synapses rate replenishment depleted vesicles constant, determining an inverse relationship...