A5058324116- Down syndrome and intellectual disability research
- Genomic variations and chromosomal abnormalities
- Genetics and Neurodevelopmental Disorders
- Mindfulness and Compassion Interventions
- Sleep and related disorders
- Stress Responses and Cortisol
- Forgiveness and Related Behaviors
- Chemotherapy-induced cardiotoxicity and mitigation
- Neuroscience, Education and Cognitive Function
- Child and Adolescent Psychosocial and Emotional Development
- Paraoxonase enzyme and polymorphisms
- Thyroid Disorders and Treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Spaceflight effects on biology
- Prenatal Screening and Diagnostics
- Pluripotent Stem Cells Research
- Cardiac Imaging and Diagnostics
- Chronic Disease Management Strategies
- Obstructive Sleep Apnea Research
- Peptidase Inhibition and Analysis
- Medical Coding and Health Information
- Posttraumatic Stress Disorder Research
- Circadian rhythm and melatonin
- Connective tissue disorders research
- Chromosomal and Genetic Variations
University of Redlands
2005-2024
GTx (United States)
2012
Jerry L. Pettis Memorial VA Medical Center
2010-2011
Loma Linda University
2010-2011
University of Wisconsin–Madison
2008
Johns Hopkins University
2002-2005
Johns Hopkins Medicine
2002-2005
Pennsylvania State University
2004
The "Down syndrome critical region" (DSCR) is a chromosome 21 segment purported to contain genes responsible for many features of Down (DS), including craniofacial dysmorphology. We used engineering create mice that were trisomic or monosomic only the mouse orthologous DSCR and assessed dysmorphologies skeleton show direct parallels with DS in larger segmental trisomy. not sufficient largely necessary produce facial phenotype. These results refute specific predictions prevailing hypothesis...
Trisomic Ts65Dn mice show direct parallels with many phenotypes of Down syndrome (DS), including effects on the structure cerebellum and hippocampus. A small segment Hsa21 known as 'DS critical region' (DSCR) has been held to contain a gene or genes sufficient cause impairment in learning memory tasks involving To test this hypothesis, we developed Ts1Rhr Ms1Rhr mouse models that are, respectively, trisomic monosomic for region. Here, trisomy DSCR alone is not produce structural functional...
Two mouse models are widely used for Down syndrome (DS) research. The Ts65Dn carries a small chromosome derived primarily from 16, causing dosage imbalance approximately half of human 21 orthologs. These mice have cerebellar pathology with direct parallels to DS. Ts1Cje mouse, containing translocated is at 67% the genes triplicated in Ts65Dn. We quantified volume and granule cell Purkinje density Ts1Cje. Cerebellar was significantly affected same degree Ts65Dn, despite that has fewer genes....
Abstract Down syndrome (DS) results from inheritance of three copies human chromosome 21 (Hsa21). Individuals with DS have a significantly smaller brain size overall and disproportionately small cerebellum. The cerebellum is seen in Ts65Dn mice, which segmental trisomy for orthologs about half the genes on Hsa21 provide genetic model DS. While cerebellar well‐established mouse humans, much less known shape trisomy. Here we conduct morphometric analysis whole mice show that differences...
Mindfulness-based interventions have been shown to psychological benefits in college students. We explored the effects of an academic Seminar on Compassion student health.Forty-one participants (14 male, 27 female, mean age 19.8 ± 1.4 years) were assessed pre- and post- spring semesters 2013 2014.Students randomized or a wait-list control group. Participants completed self-report measures anxiety, depression, perceived stress, self-compassion, compassion mindfulness. Salivary alpha-amylase...
Abstract Genetic factors are known to contribute seizure susceptibility, although the long-term effects of these predisposing on neuronal viability remain unclear. To examine consequences genetic conferring increased we surveyed a class Drosophila mutants that exhibit seizures and paralysis following mechanical stimulation. These bang-sensitive shortened life spans age-dependent neurodegeneration. Because susceptibility in likely results from altered metabolism since Na+/K+ ATPase consumes...
Abstract Down syndrome (trisomy 21) is associated with reduced bone density in humans, but it unclear whether this due to specific effects of chromosome 21 genes or lifestyle factors. Mouse models aneuploidy segments mouse 16 that are homologous human can be used elucidate the mechanism by which phenotypes arise. Ts1Rhr and Ms1Rhr mice trisomic monosomic, respectively, for hypothesized “Down critical region” containing approximately 33 genes. We assessed skeletons these from 3 weeks age...
The anthracycline chemotherapeutic agent doxorubicin is converted by the enzyme carbonyl reductase 1 (CBR1) into its cardiotoxic metabolite doxorubicinol. Cbr1+/− mice have been shown to be protected from doxorubicin-induced cardiotoxicity, and inhibition of CBR1 activity may a useful means ameliorating side effects in patients undergoing chemotherapy. Because reduced conversion doxorubicinol increases circulating levels more effective parent drug doxorubicin, it was hypothesized that...
Abstract. Tasks such as the Trier Social Stress Test, narrative recall, and some cognitive challenges require participants to speak in order measure acute physiological responses induced stress. Typically, measures during stressed state are compared a silent baseline period. This does not differentiate between stress that is by emotion due physical act of vocalization. We modified psychosocial task for 41 add period neutral speaking. hypothesized there would be significant differences...
Abstract Introduction Many over-the-counter products such as bubble baths, room sprays, and lotions claim they contain the pineal hormone melatonin promote sleep. In this randomized, controlled, double-blind crossover trial we compared impact of a commercial “sleep lotion” versus placebo control lotion. Methods Participants applied on two different nights, one hour before bedtime. To assess whether was absorbed through skin circulating systemically, conducted enzyme linked immunosorbent...
A Continuous Performance Task is an example of a mental stressor which requires vigilance, attention, and effort. We hypothesized that sympathetic nervous system response would be evident from resting baseline period to this attention test, explored if physiological measures were correlated state trait anxiety, perceived stress, mindfulness, performance on the task. In 20 undergraduates, blood pressure skin conductance increased due test but heart rate variability did not change. The...
Abstract. Narrative recall, or describing an event from one’s past, is a common method to study anger in the laboratory. However, most research using this has not included neutral speaking control, and therefore physiological response attributable emotion versus act of speech unknown. We evaluated heart rate, blood pressure, skin conductance level, rate variability, salivary alpha-amylase during silent baseline, speaking, recovery periods, correlated these measures with trait anger,...
Many over-the-counter products such as bubble baths, room sprays, and lotions claim they contain the pineal hormone melatonin promote sleep. In this randomized, controlled, double-blind crossover trial we compared impact of a commercial “sleep lotion” versus placebo control lotion. Our sample 63 undergraduate college students scored an average 6.3 ± 2.7 on Global Pittsburgh Sleep Quality Index, with 65% above cutoff 5 indicating poor sleep quality in previous 30 days. Participants applied...
A variety of mouse models for Down syndrome (Trisomy 21) have been created to test hypotheses about the correlation phenotypes gene content and copy number. Ts1Rhr mice are trisomic a region on chromosome 16 that is homologous 5.3 Mb human 21. Ms1Rhr monosomic this region. Magnetic Resonance Imaging (MRI) has revealed characteristic volumetric changes in brains humans with such as reductions cerebellum, hippocampus, brain stem, increases ventricles thalamus. We used MRI interest analysis...