A5032756891- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Tryptophan and brain disorders
- Fatty Acid Research and Health
- Eicosanoids and Hypertension Pharmacology
- Inflammasome and immune disorders
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Dementia and Cognitive Impairment Research
- Barrier Structure and Function Studies
- Diet and metabolism studies
- GDF15 and Related Biomarkers
- Gastroesophageal reflux and treatments
University of California, Los Angeles
2018-2020
VA Greater Los Angeles Healthcare System
2019
University of Ulster
2017-2018
West Los Angeles College
2018
Los Angeles Medical Center
2018
Paul Hastings
2018
Queen's University Belfast
2013
Aims To demarcate pathological events in the brain as a result of short‐term to chronic high‐fat‐diet (HFD) feeding, which leads cognitive impairment and neuroinflammation, assess efficacy Xenin‐25[Lys(13)PAL] HFD‐fed mice. Methods C57BL/6 mice were fed an HFD or normal diet for 18 days, 34 10 21 weeks. Cognition was assessed using novel object recognition Morris water maze. Markers insulin signalling inflammation measured plasma immunohistochemistry, quantitative PCR multi‐array technology....
Cerebral and systemic organ microvascular pathologies coexist with human Alzheimer's disease (AD) neuropathology. In this study, we hypothesised that both cerebral exist in 4- to 5-month-old male APPswe/PS1dE9 (APP/PS1) transgenic mice prior the onset of cognitive impairment. To assess examined recognition memory wild-type APP/PS1 using object task (ORT; n = 11 per group) counted thioflavin-S-positive plaques brain (n 6 group). Vascular casts brain, liver, spleen kidneys were scanning...
Neuroinflammation plays a crucial role in the development and progression of Alzheimer's disease (AD), which activated microglia are found to be associated with neurodegeneration. However, there is limited evidence showing how neuroinflammation directly linked neurodegeneration vivo. Besides, currently no effective anti-inflammatory drugs for AD. In this study, we report on an lipid, linoleic acid (LA) metabolite docosapentaenoic (DPAn-6) treatment aged humanized EFAD mice advanced AD...
Alzheimer's disease (AD) and mixed dementia (MxD) comprise the majority of cases in growing global aging population. MxD describes coexistence AD pathology with vascular pathology, including cerebral small vessel (SVD). Cardiovascular increases risk for MxD, but mechanistic synergisms between coexisting pathologies affecting risk, progression ultimate clinical manifestations remain elusive. To explore additive or synergistic interactions chronic hypertension, we developed a rat model...
To investigate the role of psychological characteristics as risk factors for oesophageal adenocarcinoma (OAC), well reflux-mediated precursor pathway.An all-Ireland population-based case-control study recruited 230 reflux oesophagitis (RO), 224 Barrett's oesophagus (BO) and 227 OAC patients 260 controls. Each case/control group completed measures stress, depression, self-efficacy, self-esteem, repression social support. A comparative analysis was undertaken using polytomous logistic...
Around 95% of Alzheimer's disease (AD) cases are sporadic AD that occurs through the interaction genetic and environmental risk factors. APOE4 for is modulated by dietary fatty acids such saturated trans-unsaturated fat increase risk, while monounsaturated polyunsaturated (MUFA, PUFA) reduce risk. Among PUFAs, omega-3 (n-3) like docosohexaenoic acid (DHA) have been extensively studied associate with positive effects in humans models, but role n-6 linoleic (LA) largely considered to be...
The majority of older patients with dementia have Alzheimer disease (AD) pathology, but other factors, the most common being vascular contribute to a mixed that may not respond treatment directed at pure AD. To create new genetic model mix and we bred mutant APP PS1 transgenes from AD-F344 rats developing Aß tau pathology onto stroke prone spontaneously hypertensive SHR-SP rats, best studied for small vessel (SVD) cognitive impairment (VCI). We evaluated blood pressure (BP) AD endpoints...