A5000367146- RNA Research and Splicing
- RNA modifications and cancer
- Medical Imaging and Pathology Studies
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- RNA and protein synthesis mechanisms
Seoul National University Hospital
2020-2023
A relatively low response to chemotherapy has been reported for hormone receptor (HR)-positive breast cancer. In this study, we investigated the role of tryptophanyl-transfer RNA synthetase (WARS) in chemotherapeutic HR-positive cancer.Pre-chemotherapeutic needle biopsy samples 45 cancer patients undergoing same regimen were subjected immunohistochemistry. To investigate biological functions WARS cancer, conducted cell viability assay, flow cytometry analysis, caspase activity Quantitative...
Abstract There are several unmet needs remained to be solved in bladder urothelial lesions. Especially, the molecular biology of inverted papilloma (IUP) as a precursor disease carcinoma is poorly understood. Also, muscle-invasive (MIUC) bladder, showing highly aggressive tumor behavior, has prompted quest for robust biomarkers associated with invasion. A total 265 tissue specimens from urinary were enrolled proteomic analysis and validation. Candidate selected through bioinformatic...